The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Protective effect of Poncirus trifoliata and Citrus aurantium extract on acute pancreatitis in mice model

급성췌장염 마우스 모델에서 지실과 지각 추출물의 보호효과

  • Park, Kyoung-Chel (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Bae, Gi-Sang (Hanbang Body-fluid Research Center, Wonkwang University) ;
  • Choi, Sun-Bok (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Jo, Il-Joo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Gwak, Tae-Sin (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Lee, Guem-San (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Park, Sung-Joo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Song, Ho-Joon (Dept. of Herbology, College of Oriental Medicine, Wonkwang University)
  • 박경철 (원광대학교 한의과대학 본초학교실) ;
  • 배기상 (원광대학교 한방체액조절연구센터) ;
  • 최선복 (원광대학교 한의과대학 본초학교실) ;
  • 조일주 (원광대학교 한의과대학 본초학교실) ;
  • 곽태신 (원광대학교 한의과대학 본초학교실) ;
  • 이금산 (원광대학교 한의과대학 본초학교실) ;
  • 박성주 (원광대학교 한의과대학 본초학교실) ;
  • 송호준 (원광대학교 한의과대학 본초학교실)
  • Received : 2012.08.11
  • Accepted : 2012.09.05
  • Published : 2012.09.30
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Abstract

Objective : We investigated the effect of Poncirus trifoliata and Citrus aurantium extract in mice with cerulein-induced acute pancreatitis (AP) model. Methods : AP was induced via intraperitoneal injection of cerulein (50 ${\mu}g/kg$) given every hour for 6h. Poncirus trifoliata (PT: 200 or 400 mg/kg) and Citrus aurantium (CA: 200 or 400 mg/kg) extract were injected 1 h before in mice with cerulein-induced AP. Mice were sacrificed at 6 h after last injection of cerulein. Blood samples were taken to determine serum amylase and lipase levels. The pancreas and lungs were rapidly removed for morphological examination, myeloperoxidase assay. Results : PT pre-treatment significantly protected the pancreas and lung damages and reduced the MPO activity and serum amylase in cerulein-induced AP. However, CA pre-treatment did not significantly protected the pancreas and lung inflammation in cerulein-induced AP. Conclusion : These results suggest that PT but not CA could protect the cerulein-induced AP. Conclusion : These results suggest that PT but not CA could protect the cerulein-induced AP.

Keywords

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