The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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A Comparative Study of Memory Improving Effects of Taraxaci herba on Scopolamine-induced Amnesia in Mouse

포공영 기원식물의 mouse 기억력 개선효과 비교

  • Sohn, Moon-Ki (Department of Agronomy & Medicinal Plant Resources, Gyeongnam national University of Science and Technology) ;
  • Shin, Yong-Wook (Department of Agronomy & Medicinal Plant Resources, Gyeongnam national University of Science and Technology)
  • 손문기 (경남과학기술대학교 농학.한약자원학부) ;
  • 신용욱 (경남과학기술대학교 농학.한약자원학부)
  • Received : 2012.08.16
  • Accepted : 2012.09.06
  • Published : 2012.09.30
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Abstract

Objectives : The purpose of this study was to characterize the effect of the fraction of Taraxacum officinale and T.coreanum on the learning and memory impairments induced by scopolamine. Methods : The cognition-enhancing effect of Taraxacum officinale and T.coreanum was investigated using a passive avoidance test, the Morris water maze test and Y-maze test in mice. Drug-induced amnesia was induced by treating animals with scopolamine (1 mg/kg, i.p.). Results : The results showed that the Aug harvested T.offiicinale extract-treated group (200 mg/kg, p.o.) and the tacrine-treated group (10 mg/kg, p.o.) significantly ameliorated scopolamine-induced amnesia based on the Passive avoidance Y-maze test and Watermaze test. And these results are same manner in DPPH radical scavenger effect and Acetylcholineseterase inhibition effect. Conclusions : These results suggest that Taraxacum officinale extract maybe a useful cognitive impairment treatment, and its beneficial effects are depending on the collecting time and origin plants. As a result, Taraxacum officinale harvested in August improve memory most.

Keywords

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