Journal of Environmental Science International (한국환경과학회지)

The Korean Environmental Sciences Society (한국환경과학회)
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Studies of the Cordyceps militaris Extract Administration on the Metabolic Enzyme Activities in Hypercholesterolemia

동충하초 엑스의 고콜레스테롤혈증 대사효소 활성 변동에 관한 효과

  • Kim, Han-Soo (Department of Food Science & Technology, Pusan National University) ;
  • Kim, Min-A (Department of Food Science & Technology, Pusan National University) ;
  • Jang, Seong-Ho (Department of Bioenviromental Energy, Pusan National University) ;
  • Kang, Jin-Soon (School of Food Science, International University of Korea) ;
  • Lee, Won-Ki (Department of Polymer Engineering, Pukyung National University) ;
  • Ryu, Jae-Young (Division for Industrial & Environmental Research, Korea Atomic Energy Research Institute (KAERI))
  • 김한수 (부산대학교 식품공학과) ;
  • 김민아 (부산대학교 식품공학과) ;
  • 장성호 (부산대학교 바이오환경에너지학과) ;
  • 강진순 (한국국제대학교 식품과학부) ;
  • 이원기 (부경대학교 고분자공학과) ;
  • 류재용 (한국원자력연구원 공업환경연구부)
  • Received : 2012.06.18
  • Accepted : 2012.07.18
  • Published : 2012.10.31
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Abstract

The objective of this study was to investigate the effects of the feeding Cordyceps militaris extract on the improvement of the free fatty acid, lipid peroxide, creatinine and enzyme (creatine phosphokinase; CPK, lactate dehydrogenase; LDH, alkaline phosphatase; ALP, lecithin cholesterol acyltransferase; LCAT) activities in the sera of dietary hypercholesterolemic rats (SD strain, male) fed the experimental diets for 5 weeks. Concentrations of free fatty acid, lipid peroxide and CPK, LDH, ALP activities in sera were fairly reduced in the Cordyceps militaris extract administration group (CHE) than in the hypercholesterolemic diet group (CHD). However, no significance was found in the effect of an creatinine concentration among the groups. The LCAT activity in serum was increased in the Cordyceps militaris extract administration (CHE) than in the hypercholesterolemic diet group (CHD). From these results, Cordyceps militaris extracts were effective on the improvement of the lipid components and metabolic enzyme activities in sera of dietary hypercholesterolemic rats.

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References

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