YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Cognitive Enhancing Activity of the Steamed and Fermented Extracts of Codonopsis lanceolata Radix

양유(洋乳)의 증숙 및 발효 추출물의 인지능 개선 활성

  • Weon, Jin Bae (Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University) ;
  • Yun, Bo-Ra (Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University) ;
  • Lee, Jiwoo (Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University) ;
  • Eom, Min Rye (Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University) ;
  • Lee, Hyeon Yong (Department of Teaics, Seowon University) ;
  • Park, Dong-Sik (Functional Food & Nutrition Division, Department of Agrofood Resources) ;
  • Chung, Hee-Chul (Newtree CO., LTD.) ;
  • Chung, Jae Youn (Newtree CO., LTD.) ;
  • Ma, Choong Je (Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University)
  • 원진배 (강원대학교 생물의소재공학과) ;
  • 윤보라 (강원대학교 생물의소재공학과) ;
  • 이지우 (강원대학교 생물의소재공학과) ;
  • 엄민례 (강원대학교 생물의소재공학과) ;
  • 이현용 (서원대학교 차학과(식품공학과)) ;
  • 박동식 (농촌진흥청 국립농업과학원 기능성식품과) ;
  • 정희철 ((주)뉴트리) ;
  • 정재윤 ((주)뉴트리) ;
  • 마충제 (강원대학교 생물의소재공학과)
  • Received : 2013.06.26
  • Accepted : 2013.09.10
  • Published : 2013.10.31
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Abstract

This study was designed to determine and compare the cognitive enhancing effect of various Codonopsis lanceolata extracts by steaming, fermentation and high hydrostatic pressure process. We prepared water extract of C. lanceolata, steamed C. lanceolata, steamed and fermented C. lanceolata and C.lanceolata by high hydrostatic pressure process and fermentation. Cognitive enhancing effect of extracts was evaluated in scopolamine-induced memory impairment mice using by passive avoidance test and Morris water maze tests. MTT assay was conducted to investigate neuroprotective effect on glutamate induced cell death in HT22 cells. Steamed and fermented C. lanceolata water extract decreased escape latency in Morris water maze test and increased the latency time of the passive avoidance test compared to other extracts. Furthermore, the steamed and fermented C. lanceolata water extract showed neuroprotective effect. These results suggest that steaming and fermentation process more improve cognitive enhancing effect of C. lanceolata than other process.

Keywords

References

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