Journal of Radiation Protection and Research

The Korean Association for Radiation Protection (대한방사선방어학회)
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DOSE AND DOSE RATE EFFECTS OF IRRADIATION ON BLOOD COUNT AND CYTOKINE LEVEL IN BALB/c MICE

  • Son, Yeonghoon (Dongnam institute of radiological & Medical Sciences (DIRAMS)) ;
  • Jung, Dong Hyuk (Dongnam institute of radiological & Medical Sciences (DIRAMS)) ;
  • Kim, Sung Dae (Dongnam institute of radiological & Medical Sciences (DIRAMS)) ;
  • Lee, Chang Geun (Dongnam institute of radiological & Medical Sciences (DIRAMS)) ;
  • Yang, Kwangmo (Dongnam institute of radiological & Medical Sciences (DIRAMS)) ;
  • Kim, Joong Sun (Dongnam institute of radiological & Medical Sciences (DIRAMS))
  • Received : 2013.11.05
  • Accepted : 2013.11.29
  • Published : 2013.12.30
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Abstract

The biological effects of radiation are dependent on the dose rate and dose of radiation. In this study, effects of dose and dose rate using whole body radiation on plasma cytokines and blood count from male BALB/c mice were evaluated. We examined the blood and cytokine changes in mice exposed to a low (3.49m Gy $h^{-1}$) and high (2.6 Gy $min^{-1}$) dose rate of radiation at a total dose of 0.5 and 2 Gy, respectively. Blood from mice exposed to radiation were evaluated using cytokine assays and complete blood count. Peripheral lymphocytes and neutrophils decreased in a dose dependent manner following high dose rate radiation. The peripheral lymphocytes population remained unchanged following low dose rate radiation; however, the neutrophils population increased after radiation. The sera from these mice exhibited elevated levels of flt3 ligand and granulocyte-colony-stimulating factor (G-CSF), after high/low dose rate radiation. These results suggest that low-dose-rate radiation does not induce blood damage, which was unlike high-dose-rate radiation treatment; low-dose-rate radiation exposure activated the hematopoiesis through the increase of flt3 ligand and G-CSF.

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References

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