Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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GSTP1 Gene Ile105Val Polymorphism Causes an Elevated Risk for Bladder Carcinogenesis in Smokers

  • Published : 2013.11.30
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Abstract

Background: The glutathione S transferase (GST) family of enzymes plays a vital role in the phase II biotransformation of environmental carcinogens, pollutants, drugs and other xenobiotics. GSTs are polymorphic and polymorphisms in GST genes have been associated with cancer susceptibility and prognosis. GSTP1 is associated with risk of various cancers including bladder cancer. A case control study was conducted to determine the genotype distribution of GSTP1 A>G SNP, to elucidate the possible role of this SNP as a risk factor in urinary bladder cancer (UBC) development and to examine its correlation with clinico-pathologic variables inUBC cases. Materials and Methods: Using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) approach, we tested the genotype distribution of 180 bladder cancer patients in comparison with 210 cancer-free controls from the same geographical region with matched frequency in age and gender. Results: We did not observe significant genotype differences between the control and bladder cancer patients overall with an odds ratio (OR)=1.23 (p>0.05). The rare allele (AG+GG) was found to be present more in cases (28.3%) than in controls (24%), though the association was not significant (p<0.05). However, a significant risk of more than 2-fold was found for the variant allele (AG+GG) with smokers in cases as compared to controls (p>0.05). Conclusions: Thus, it is evident from our study that GSTP1 SNP is not implicated overall in bladder cancer, but that the rare, valine-related allele is connected with higher susceptibility to bladder cancer in smokers and also males.

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References

  1. Ali-Osmam F, Akande O, Antoun G (1997). Molecular cloning, characterization and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase pi gene variants. Evidence for different catalytic activity of the encoded proteins. J Biol Chem, 272, 10,004-12.
  2. Arshad AP, Mushtaq AS (2012). Burden of cancers in the valley of Kashmir: 5 year epidemiological study reveals a different scenario. Tumor Biol, 33, 1629-37. https://doi.org/10.1007/s13277-012-0418-z
  3. Brauers A, Jakse G (2000). Epidemiology and biology of human urinary bladder cancer. J Cancer Res Clin Oncol, 126, 575-83. https://doi.org/10.1007/PL00008467
  4. Clavel J (2007). Progress in the epidemiological understanding of gene environment interactions in major diseases. Cancer CR Biol, 330, 306-17. https://doi.org/10.1016/j.crvi.2007.02.012
  5. Clayson DB (1998). Specific aromatic amines as occupational bladder carcinogens. Natl Cancer Inst Monog, 58, 15-9.
  6. Cao W, Cai L, Rao JY, et al (2005). Tobacco smoking, GSTP1 polymorphism, and bladder carcinoma. Cancer, 104, 2400-8. https://doi.org/10.1002/cncr.21446
  7. Hayes JD, Pulford DJ (1995). The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol, 30, 445-600. https://doi.org/10.3109/10409239509083491
  8. Helzlsouer KJ, Selmin O, Huang HY, et al (1998). Association between glutathione S-transferase M1, P1, and T1 genetic polymorphisms and development of breast cancer. J Natl Cancer Inst, 90, 512-8. https://doi.org/10.1093/jnci/90.7.512
  9. Katoh T, Kaneko S, Takasawa S (1999). Human glutathione S-transferase P1 polymorphism and susceptibility to smoking related epithelial cancer, oral, lung, gastric, colorectal and urothelial cancer. Pharmacogenetics, 9, 165-9.
  10. Miller SL, Dykes DD, Polesky HF (1988). A simple salting out procedure for extracting DNA from human nucleated cells. Nuc Acid Res, 16, 1215. https://doi.org/10.1093/nar/16.3.1215
  11. Ploeg M, Aben KK, Kiemeney L (2009). The present and future burden of urinary bladder cancer in the world. World J Urol, 27, 289-93. https://doi.org/10.1007/s00345-009-0383-3
  12. Pradubkaew K, Pramyothin P, Limwongse C, Suwannasri P, Assawamakin A (2009). Glutathione S-transferase polymorphisms and risk of bladder cancer in Thais. Thai J Pharm Sci, 33, 3367-73.
  13. Mittal RD, Srivastava DS, A M, B M (2005). Genetic polymorphism of drug metabolizing enzymes (CYP2E1, GSTP1) and susceptibility to bladder cancer in North India. Asian Pac J Cancer Prev, 6, 6-9.
  14. Ryberg D, Skaug V, Hewer A, et al (1997). Genotypes of glutathione transferase M1 and P1 and their significance for lung DNA adduct levels and cancer risk. Carcinogenesis, 18, 1285-9. https://doi.org/10.1093/carcin/18.7.1285
  15. Srivastava DS, Mishra DK, Mandhani A, et al (2005). Association of genetic polymorphism of glutathione S-transferase M1, T1, P1 and susceptibility to bladder cancer. Eur Urol, 48, 339-44. https://doi.org/10.1016/j.eururo.2005.02.007
  16. Steinhoff C, Franke KH, Golka K (2000). A glutathione transferase isozyme genotypes in patients with prostate and bladder carcinoma. Arch Toxicol, 74, 521-6. https://doi.org/10.1007/s002040000161
  17. Strange RC, Hayes JD (2000). Glutathione S-transferase polymorphisms and their biological consequences. Pharmacology, 61, 154-66. https://doi.org/10.1159/000028396
  18. Toruner GA, Akyerli C, Ucar A, et al (2001). Polymorphisms of glutathione S-transferase genes (GSTM1, GSTP1 and GSTT1) and bladder cancer susceptibility in the Turkish population. Arch Toxicol, 75, 459-64. https://doi.org/10.1007/s002040100268
  19. V V, K V, Paul SF, P V (2006). Genetic variation of GSTM1, GSTT1 and GSTP1 genes in a South Indian population. Asian Pac J Cancer Prev, 7, 325-8.
  20. Vijayalakshmi K, Vettriselvi V, Krishnan M (2005). Polymorphisms at GSTM1 and GSTP1 gene loci and risk of prostate cancer in a south Indian population. Asian Pac J Cancer Prev, 6, 309-14.
  21. Welfare M, Monesola AA, Bassendine MF, Daly AK (1999). Polymorphisms in GSTP1, GSTM1, and GSTT1 and susceptibility to colorectal cancer. Cancer Epidemiol Biomarkers Prev, 8, 289-92.
  22. Whalen R, Boyer T (1998). Human glutathione S-transferases. Semin Liver Dis, 18, 345-58. https://doi.org/10.1055/s-2007-1007169
  23. Senthilkumar KP, Thirumurugan R (2012). GSTM1 and GSTT1 allele frequencies among various Indian and non-Indian ethnic groups. Asian Pac J Cancer Prev, 13, 6263-7. https://doi.org/10.7314/APJCP.2012.13.12.6263
  24. Sharma A, Pandey A, Sardana S, et al (2012). Genetic polymorphisms of GSTM1 and GSTT1 genes in Delhi and comparison with other Indian and global populations. Asian Pac J Cancer Prev, 13, 5647-52. https://doi.org/10.7314/APJCP.2012.13.11.5647
  25. Zhou LP, Luan H, Dong XH, et al (2012). Genetic variants of CYP2D6 gene and cancer risk: a HuGE systematic reviewand meta-analysis. Asian Pac J Cancer Prev, 13, 3165-72. https://doi.org/10.7314/APJCP.2012.13.7.3165

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