DOI QR코드

DOI QR Code

Human Papillomavirus Genotypes and Cervical Cancer in Northeast Thailand

  • Natphopsuk, Sitakan (Department of Physiology, Faculty of Public Health, Khon Kaen University) ;
  • Settheetham-Ishida, Wannapa (Department of Physiology, Faculty of Public Health, Khon Kaen University) ;
  • Pientong, Chamsai (Department of Microbiology, Faculty of Public Health, Khon Kaen University) ;
  • Sinawat, Supat (Department of Physiology, Faculty of Public Health, Khon Kaen University) ;
  • Yuenyao, Pissamai (Department of Obstetrics and Gynecology, Surin Hospital) ;
  • Ishida, Takafumi (Department of Biological Sciences, Graduate School of Science, The University of Tokyo) ;
  • Settheetham, Dariwan (Department of Environmental Health, Faculty of Public Health, Khon Kaen University)
  • Published : 2013.11.30

Abstract

Human papillomavirus (HPV) is a major cause of cervical cancer. More than 100 HPV genotypes have been identified; however the distribution varies geographically and according to ethnicity. The purpose of this study was to investigate the prevalence and distribution of HPV subtypes among Northeast Thai women. Subjects included 198 cases of SCCA and 198 age-matched, healthy controls. HPV-DNA was amplified by PCR using the consensus primers GP5+/6+ system followed by reverse line blot hybridization genotyping. The prevalence of high-risk HPV infection was 21 (10.1%) and 152 (76.8%) in the controls and in the cases, respectively. High-risk HPV significantly increased the risk for cervical cancer with an OR of 42.4 (95%CI: 22.4-81.4, p<0.001) and an adjusted OR of 40.7-fold (95%CI: 21.5-76.8, p <0.001). HPV-16 was the most prevalent HPV type in the SCCA (56.2%) followed by HPV-58 (17.8%) and HPV-18 (13.6%); whereas HPV-58 (46.4%) was a prominent genotype in the controls followed by HPV-16 (39.3%) and unidentified HPV types (25.0%). These findings indicate that HPV infection remains a critical risk factor for SCCA; particularly, HPV-16, HPV-58 and HPV-18. In order to eradicate cervical cancer, sustained health education, promoted use of prophylactics and a HPV-58 vaccine should be introduced in this region.

Keywords

References

  1. Bhatla N, Lal N, Bao YP, Ng T, Qiao YL (2008). A meta-analysis of human papillomavirus type-distribution in women from South Asia: implications for vaccination. Vaccine, 26, 2811-7. https://doi.org/10.1016/j.vaccine.2008.03.047
  2. Camargo M, Soto-De Leon S, Sanchez R, et al (2011). Detection by PCR of human papillomavirus in Colombia: Comparison of GP5+/6+ and MY09/11 primer sets. J Virol Methods, 178, 68-74. https://doi.org/10.1016/j.jviromet.2011.08.014
  3. Chan PK, Cheung JL, Cheung TH, et al (2007). HLA-DQB1 polymorphisms and risk for cervical cancer: a case-control study in a southern Chinese population. Gynecol Oncol, 105, 736-41. https://doi.org/10.1016/j.ygyno.2007.02.013
  4. Chansaenroj J, Lurchachaiwong W, Termrungruanglert W, et al (2010). Prevalence and genotypes of human papillomavirus among Thai women. Asian Pac J Cancer Prev, 11, 117-22.
  5. Chichareon S, Herrero R, Munoz N, et al (1998). Risk factors for cervical cancer in Thailand: a case-control study. J Natl Cancer Inst, 90, 50-7. https://doi.org/10.1093/jnci/90.1.50
  6. Chinchai T, Chansaenroj J, Swangvaree S, Junyangdikul P, Poovorawan Y (2012). Prevalence of human papillomavirus genotypes in cervical cancer. Int J Gynecol Cancer, 22, 1063-8. https://doi.org/10.1097/IGC.0b013e318259d904
  7. de Sanjose S, Diaz M, Castellsague X, et al (2007). Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis. Lancet Infect Dis, 7, 453-9. https://doi.org/10.1016/S1473-3099(07)70158-5
  8. Domingo EJ, Noviani R, Noor MR, et al (2008). Epidemiology and prevention of cervical cancer in Indonesia, Malaysia, the Philippines, Thailand and Vietnam. Vaccine, 26, 71-9. https://doi.org/10.1016/j.vaccine.2008.05.039
  9. Ferlay J, Shin HR, Bray F, et al (2010). Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer, 127, 2893-917. https://doi.org/10.1002/ijc.25516
  10. Goldsmith DB, West TM, Morton R (2002). HLA associations with nasopharyngeal carcinoma in Southern Chinese: a meta-analysis. Clin Otolaryngol Allied Sci, 27, 61-7. https://doi.org/10.1046/j.0307-7772.2001.00529.x
  11. Huang LW, Chao SL, Chen PH, Chou HP (2004). Multiple HPV genotypes in cervical carcinomas: improved DNA detection and typing in archival tissues. J Clin Virol, 29, 271-6. https://doi.org/10.1016/S1386-6532(03)00167-7
  12. Huang S, Afonina I, Miller BA, Beckmann AM (1997). Human papillomavirus types 52 and 58 are prevalent in cervical cancers from Chinese women. Int J Cancer, 70, 408-11. https://doi.org/10.1002/(SICI)1097-0215(19970207)70:4<408::AID-IJC6>3.0.CO;2-#
  13. Kawana K, Adachi K, Kojima S, Kozuma S, Fujii T (2012). Therapeutic Human papillomavirus (HPV) Vaccines: a novel approach. Open Virol J, 6, 264-9. https://doi.org/10.2174/1874357901206010264
  14. Konno R, Shin HR, Kim YT, et al (2008). Human papillomavirus infection and cervical cancer prevention in Japan and Korea. Vaccine, 26, 30-42.
  15. Liaw KL, Hildesheim A, Burk RD, et al (2001). A prospective study of human papillomavirus (HPV) type 16 DNA detection by polymerase chain reaction and its association with acquisition and persistence of other HPV types. J Infect Dis, 183, 8-15. https://doi.org/10.1086/317638
  16. Lurchachaiwong W, Junyangdikul P, Payungporn S, et al (2011). Human papillomavirus genotypes among infected Thai women with different cytological findings by analysis of E1 genes. New Microbiol, 34, 147-56.
  17. National Cancer Institute (2012). Hospital-based cancer registry 2011. Bangkok.
  18. Romphruk AV, Puapairoj C, Romphruk A, et al (1999). Distributions of HLA-DRB1/DQB1 alleles and haplotypes in the north-eastern Thai population: indicative of a distinct Thai population with Chinese admixtures in the central Thais. Eur J Immunogenet, 26, 129-33. https://doi.org/10.1046/j.1365-2370.1999.00133.x-i2
  19. Romphruk AV, Romphruk A, Kongmaroeng C, et al (2010). HLA class I and II alleles and haplotypes in ethnic Northeast Thais. Tissue Antigens, 75, 701-11. https://doi.org/10.1111/j.1399-0039.2010.01448.x
  20. Serrano B, Alemany L, Tous S, et al (2012). Potential impact of a nine-valent vaccine in human papillomavirus related cervical disease. Infect Agent Cancer, 7, 38. https://doi.org/10.1186/1750-9378-7-38
  21. Settheetham-Ishida W, Kanjanavirojkul N, Kularbkaew C, Ishida T (2005). Human papillomavirus genotypes and the p53 codon 72 polymorphism in cervical cancer of Northeastern Thailand. Microbiol Immunol, 49, 417-21. https://doi.org/10.1111/j.1348-0421.2005.tb03745.x
  22. Shi JF, Qiao YL, Smith JS, et al (2008). Epidemiology and prevention of human papillomavirus and cervical cancer in China and Mongolia. Vaccine, 26, 53-9.
  23. Siriaunkgul S, Suwiwat S, Settakorn J, et al (2008). HPV genotyping in cervical cancer in Northern Thailand: adapting the linear array HPV assay for use on paraffin-embedded tissue. Gynecol Oncol, 108, 555-60. https://doi.org/10.1016/j.ygyno.2007.11.016
  24. Sonoda S (1990). Genetic and immunologic determinants of HTLV-I-associated diseases. In human retrovirology: HTLV. New York W.A. Raven Press, Ltd.
  25. Sriamporn S, Snijders PJ, Pientong C, et al (2006). Human papillomavirus and cervical cancer from a prospective study in Khon Kaen, Northeast Thailand. Int J Gynecol Cancer, 16, 266-9. https://doi.org/10.1111/j.1525-1438.2006.00356.x
  26. Sukvirach S, Smith JS, Tunsakul S, et al (2003). Population-based human papillomavirus prevalence in Lampang and Songkla, Thailand. J Infect Dis, 187, 1246-56. https://doi.org/10.1086/373901
  27. Suthipintawong C, Siriaunkgul S, Tungsinmunkong K, et al (2011). Human papilloma virus prevalence, genotype distribution, and pattern of infection in Thai women. Asian Pac J Cancer Prev, 12, 853-6.
  28. Tay SK, Ngan HY, Chu TY, Cheung AN, Tay EH (2008). Epidemiology of human papillomavirus infection and cervical cancer and future perspectives in Hong Kong, Singapore and Taiwan. Vaccine, 26, 60-70. https://doi.org/10.1016/j.vaccine.2008.05.042
  29. Tungsinmunkong K, Suwiwat S, Sriplung H (2006). Detection of human papillomavirus in intraepithelial lesions and carcinoma of the cervix uteri in southern Thai women. Asian Pac J Cancer Prev, 7, 427-30.
  30. van den Brule AJ, Pol R, Fransen-Daalmeijer N, et al (2002). GP5+/6+ PCR followed by reverse line blot analysis enables rapid and high-throughput identification of human papillomavirus genotypes. J Clin Microbiol, 40, 779-87. https://doi.org/10.1128/JCM.40.3.779-787.2002
  31. Villa LL (2006). Prophylactic HPV vaccines: reducing the burden of HPV-related diseases. Vaccine, 24, 23-8. https://doi.org/10.1016/j.vaccine.2005.09.001
  32. Xue Y, Lim D, Zhi L, et al (2012). Loss of HPV16 E2 protein expression without disruption of the E2 ORF correlates with carcinogenic progression. Open Virol J, 6, 163-72. https://doi.org/10.2174/1874357901206010163
  33. Yue Y, Yang H, Wu K, et al (2013). Genetic variability in L1 and L2 genes of HPV-16 and HPV-58 in Southwest China. PLoS One, 8, 55204. https://doi.org/10.1371/journal.pone.0055204

Cited by

  1. Human Papillomavirus Genotypes Profile in Cervical Cancer Patients at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia vol.15, pp.14, 2014, https://doi.org/10.7314/APJCP.2014.15.14.5781
  2. Prevalence of High Risk Human Papillomavirus Infection with Different Cervical Cytological Features among Women Undergoing Health Examination at the National Cancer Institute, Thailand vol.15, pp.14, 2014, https://doi.org/10.7314/APJCP.2014.15.14.5879
  3. Development of In-House Multiplex Real Time PCR for Human Papillomavirus Genotyping in Iranian Women with Cervical Cancer and Cervical Intraepithelial Neoplasia vol.15, pp.15, 2014, https://doi.org/10.7314/APJCP.2014.15.15.6257
  4. Preliminary Evaluation of the in vitro Efficacy of 1, 2-di (Quinazolin-4-yl) Diselane against SiHa Cervical Cancer Cells vol.15, pp.15, 2014, https://doi.org/10.7314/APJCP.2014.15.15.6301
  5. Association of a miR-502-Binding Site Single Nucleotide Polymorphism in the 3'-Untranslated Region of SET8 and the TP53 Codon 72 Polymorphism with Cervical Cancer in the Chinese Population vol.15, pp.16, 2014, https://doi.org/10.7314/APJCP.2014.15.16.6505
  6. Type-specific Prevalence of Human Papillomavirus by Cervical Cytology among Women in Brasov, Romania vol.15, pp.16, 2014, https://doi.org/10.7314/APJCP.2014.15.16.6887
  7. Cervical Pathology in High-Risk Human Papillomavirus-Positive, Cytologically Normal Women vol.15, pp.18, 2014, https://doi.org/10.7314/APJCP.2014.15.18.7977
  8. Lack of Significant Effects of Chlamydia trachomatis Infection on Cervical Cancer Risk in a Nested Case-Control Study in North-East Thailand vol.15, pp.3, 2014, https://doi.org/10.7314/APJCP.2014.15.3.1497
  9. HPV Detection and Genotyping in Vulvar Squamous Cell Carcinoma in Northern Thailand vol.15, pp.8, 2014, https://doi.org/10.7314/APJCP.2014.15.8.3773
  10. Human Papillomavirus Genotype Distribution and E6/E7 Oncogene Expression in Turkish Women with Cervical Cytological Findings vol.15, pp.9, 2014, https://doi.org/10.7314/APJCP.2014.15.9.3997
  11. Human Papillomavirus Genotypes among Females in Mexico: a Study from the Mexican Institute for Social Security vol.15, pp.23, 2015, https://doi.org/10.7314/APJCP.2014.15.23.10061
  12. Polymorphisms and Functional Analysis of the Intact Human Papillomavirus16 E2 Gene vol.15, pp.23, 2014, https://doi.org/10.7314/APJCP.2014.15.23.10255
  13. Human Papillomavirus Genotype Distribution among Thai Women with High-Grade Cervical Intraepithelial Lesions and Invasive Cervical Cancer: a Literature Review vol.16, pp.13, 2015, https://doi.org/10.7314/APJCP.2015.16.13.5153
  14. Update knowledge on cervical cancer incidence and prevalence in Asia vol.16, pp.9, 2015, https://doi.org/10.7314/APJCP.2015.16.9.3617
  15. Molecular Genotyping of Human Papillomavirus L1 Gene in Low-Risk and High-Risk Populations in Bangkok vol.42, pp.4, 2015, https://doi.org/10.1097/OLQ.0000000000000259
  16. The Prevalence and Genotype Distribution of Human Papillomavirus in the Genital Tract of Males in Iran vol.8, pp.12, 2015, https://doi.org/10.5812/jjm.21912
  17. High performance of combined HPV testing and genotyping for HPV16/18/52/58 in triaging women with minor cervical cytological abnormalities in northern Thailand vol.88, pp.1, 2015, https://doi.org/10.1002/jmv.24290
  18. HPV16 integration probably contributes to cervical oncogenesis through interrupting tumor suppressor genes and inducing chromosome instability vol.35, pp.1, 2016, https://doi.org/10.1186/s13046-016-0454-4
  19. National and Subnational Population-Based Incidence of Cancer in Thailand: Assessing Cancers with the Highest Burdens vol.9, pp.8, 2017, https://doi.org/10.3390/cancers9080108