Laboraroty Animal Research

Korean Association for Laboratory Animal Science (한국실험동물학회)
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Inhibitory effects of a ${\beta}-dunnione$ compound MB12662 on gastric secretion and ulcers

  • Jo, In-Geun (College of Advanced Science, Dankook University) ;
  • Park, Dongsun (College of Veterinary Medicine, Chungbuk National University) ;
  • Kyung, Jangbeen (College of Veterinary Medicine, Chungbuk National University) ;
  • Kim, Dajeong (College of Veterinary Medicine, Chungbuk National University) ;
  • Cai, Jingmei (College of Veterinary Medicine, Chungbuk National University) ;
  • Kim, Jihyun (College of Veterinary Medicine, Chungbuk National University) ;
  • Kwak, Tae Hwan (KT&G Life Science Corporation R&D Center) ;
  • Yoo, Sang-Ku (Erum Biotechnologies Incorporation) ;
  • Jeong, Heon-Sang (Department Food Science and Technology, Chungbuk National University) ;
  • Kim, Yun-Bae (College of Veterinary Medicine, Chungbuk National University)
  • Published : 2013.09.30
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Abstract

The effects of a ${\beta}-dunnione$ compound MB12662 on the gastric secretion and ulcers were investigated in rats. In order to assess the effects of MB12662 on the gastric secretion and acidity, rats were subjected to pylorus ligation operation, and 6 hours later, gastric fluid was collected. Treatment with MB12662 reduced the gastric fluid volume to 47.3% of control level and increased pH. In an alcohol-induced ulcer model, rats were orally administered 3 mL/kg of ethanol, and 1 hour later, the ulcer lesions ware measured under a stereomicroscope. MB12662 reduced ulcer index in a dose-dependent manner which was much stronger than a proton-pump inhibitor pantoprazole. In a stress-induced ulcer model, rats were subjected to water-immersion restraint stress, and 5 hours later, the ulcer lesions ware examined. MB12662 also attenuated the stress-induced gastric lesions, although the efficacy of MB12662 was lower than that of pantoprazole. Therefore, it is suggested that MB12662 could be a candidate compound for the prevention or treatment of gastric ulcers induced by gastric over-secretion and alcoholic hangover.

Keywords

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