Biomaterials Research (생체재료학회지)

Korean Society for Biomaterials (한국생체재료학회)
권호 표지

Development and Efficacy Study of Hydrocolloid Membrane Containing Cuttlefish Bone for Wound Treatment

창상치료용 오적골 혼합 하이드로콜로이드 막의 개발 및 효능

  • Kwak, Moon Hwa (Department of Biomaterials Science, College of Natural Resources & Life Science, Pusan National University) ;
  • Kim, Ji Eun (Department of Biomaterials Science, College of Natural Resources & Life Science, Pusan National University) ;
  • Lee, Young Ju (Department of Biomaterials Science, College of Natural Resources & Life Science, Pusan National University) ;
  • Song, Sung Hwa (Department of Biomaterials Science, College of Natural Resources & Life Science, Pusan National University) ;
  • Go, Jun (Department of Biomaterials Science, College of Natural Resources & Life Science, Pusan National University) ;
  • Lee, Jae Won (Department of Biomaterials Science, College of Natural Resources & Life Science, Pusan National University) ;
  • In, Jung Hun (Department of Biomaterials Science, College of Natural Resources & Life Science, Pusan National University) ;
  • Kim, Eun Jung (Young Chemical Co. LTD.) ;
  • Jung, Young Jin (Department of Biomaterials Science, College of Natural Resources & Life Science, Pusan National University) ;
  • Yun, Young Hyun (Young Chemical Co. LTD.) ;
  • Hwang, Dae Youn (Department of Biomaterials Science, College of Natural Resources & Life Science, Pusan National University)
  • 곽문화 (부산대학교 생명자원과학대학 바이오소재과학과) ;
  • 김지은 (부산대학교 생명자원과학대학 바이오소재과학과) ;
  • 이영주 (부산대학교 생명자원과학대학 바이오소재과학과) ;
  • 송성화 (부산대학교 생명자원과학대학 바이오소재과학과) ;
  • 고준 (부산대학교 생명자원과학대학 바이오소재과학과) ;
  • 이재원 (부산대학교 생명자원과학대학 바이오소재과학과) ;
  • 인정훈 (부산대학교 생명자원과학대학 바이오소재과학과) ;
  • 김은정 ((주)영케미칼) ;
  • 정영진 (부산대학교 생명자원과학대학 바이오소재과학과) ;
  • 윤영현 ((주)영케미칼) ;
  • 황대연 (부산대학교 생명자원과학대학 바이오소재과학과)
  • Published : 2013.06.01
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Abstract

Cuttlefish bone (CB) which is the hard tissue acting as a floating tank in cuttlefish has application to various fields including a bone substitute, biosensor matrix substrate, antioxidant and scaffold for tissue engineering. Aim of this study was whether hydrocolloid membrane containing cuttlefish bone (HMCB) could contribute to the improvement of the wound repair process in skin of SD rats. To achieve this, HMCB was developed using the mixture dispersed CB powder in hydrocolloid, and an alteration on the histology and physiology of wound skin were observed in SD rats after the treatment of HMCB for 10 days. The dispersion solution of cuttlefish bone showed low salt concentration and electric resistance, high electrical conductivity, and medium pH level. Also, two types of HMCB (HMCB15 and HMCB30) were successfully prepared with adding two different concentrations of cuttlefish bone into hydrocolloid mixture. A significant enhancement of absorptiveness was detected in HMCB30 compared with that of HM or HMCB15, although there was no difference between HM and HMCB15. Furthermore, in animals study, the diameter of wound area was significantly shorter in HMCB30 treated group than that in either HM or HMCB15 treated group. Especially, rats treated with HMCB30 displayed significant improvement in scar tissue reduction, epithelium regeneration, angiogenesis and extracellular matrix deposition in wound area, as compare with those of HM treated group. Therefore, these results indicated that HMCB could be applied therapeutically to aid wound healing in the skin of SD rats. Also, the presented data suggest that HMCB have great potential for the treatment of burn, diabetic and chronic wound defects.

Keywords

References

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