Journal of the Korea Academia-Industrial cooperation Society (한국산학기술학회논문지)

The Korea Academia-Industrial cooperation Society (한국산학기술학회)
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Usefulness of contrast agent involving high gadolium content for myocardial viability assessment

심근생존능검사 시 가돌리늄 함유량이 높은 조영제의 유용성

  • Choi, Kwan-Woo (Department of Radiology, Asan Medical Center) ;
  • Son, Soon-Yong (Department of Radiology, Asan Medical Center) ;
  • Kim, Tae-Hyung (Department of Radiological Science, Kangwon National University) ;
  • Han, Man-Seok (Department of Radiological Science, Kangwon National University) ;
  • Lee, Ju-Hee (Department of Radiology, Asan Medical Center) ;
  • Min, Jung-Whan (Department of Radiology, Shin-Gu University)
  • 최관우 (서울아산병원 영상의학과) ;
  • 손순룡 (서울아산병원 영상의학과) ;
  • 김태형 (강원대학교 방사선학과) ;
  • 한만석 (강원대학교 방사선학과) ;
  • 이희주 (서울아산병원 영상의학과) ;
  • 민정환 (신구대학교 방사선과)
  • Received : 2013.01.14
  • Accepted : 2013.03.07
  • Published : 2013.03.31
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Abstract

The purpose of this study is to increase contrast to noise ratio(CNR) in myocardial viability test by using contrast agent which highly content gadolinium(1mmol/mL) maximizing diagnostic value. This research method that four hundred four patients were underwent the MRI scanning two hundred eighty four of them were injected commercial contrast media which have 0.5mmol/L and the rest of them were injected new contrast media(gadobutrol) which have 1mmol/mL of molarity to study the contrast difference depending on the molarity of the contrast agent signal intensities of normal ventricle and left ventricle were measured to compare and evaluate signal to noise ratio(SNR) and CNR of the images. As result, 1mmol/mL contrast agent showed higher SNR by 25.13% in myocardium and 30.74% in left ventricle. CNR was proved to be better in 1mmol/mL contrast agent by 31.29%. The results above were all statistically meaningful. Therefore, contrast agent contenting more gadolinium which was 1mmol/mL in this study, could more effectively shorten T1 relaxation time, increase the signal intensity and at the same time maximize CNR and diagnostic value. This study firstly report the usefulness of 1mmol/mL contrast agent in patients allegedly suffering cardiac diseases and it is considered to increase diagnostic value.

본 연구는 심근생존능검사 시 가돌리늄 함유량이 높은 조영제(1mmol/mL)를 사용함으로써 대조도대잡음비(CNR)를 높이고, 이로 인한 진단적 가치를 극대화 시키는데 연구의 목적을 두었다. 조사방법은 단위부피당 0.5mmol/mL의 함유량을 가진 기존의 조영제(gadoterate meglumine)를 사용한 284명과 1mmol/mL의 함유량을 가진 새로운 조영제(gadobutrol)를 사용한 120명 등 총 404명의 환자를 연구대상으로, 가돌리늄 함유량에 따른 대조도 차이를 알아보기 위하여 좌심실과 정상심근의 신호강도를 각각 측정한 후 신호대잡음비(SNR)와 CNR을 비교 평가하였다. 연구 결과, 가돌리늄 함유량이 1mmol/mL 조영제 사용 시 SNR은 심근이 25.13%, 심실이 30.74% 높았고, CNR 또한 SNR과 같이 31.29% 높았으며, 통계적으로도 매우 유의하였다. 결론적으로 가돌리늄 함유량이 높은 1mmol/mL 조영제의 사용으로 높은 T1 단축효과를 나타내어 신호강도가 커지고, 이로 인해 대조도 차이가 큰 영상을 얻어 진단적 가치가 높았다. 본 연구는 심장질환이 의심되는 환자에 대한 1mmol/mL 조영제의 유용성을 최초로 증명하여 진단적 가치를 높일 수 있다는 데에 학문적 의의가 있다.

Keywords

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