Journal of Korean Medical Science

Korean Acad Medical Sciences (대한의학회)
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RET Fusion Genes in Korean Non-Small Cell Lung Cancer

  • Yoo, Seung Soo (Department of Internal Medicine, Kyungpook National University School of Medicine) ;
  • Jin, Guang (Cancer Research Center, Yanbian University School of Basic Medicine) ;
  • Jung, Hye Jin (Departments of Biochemistry and Cell Biology, Kyungpook National University School of Medicine) ;
  • Hong, Mi Jeong (Departments of Biochemistry and Cell Biology, Kyungpook National University School of Medicine) ;
  • Choi, Jin Eun (Departments of Biochemistry and Cell Biology, Kyungpook National University School of Medicine) ;
  • Jeon, Hyo-Sung (Departments of Biochemistry and Cell Biology, Kyungpook National University School of Medicine) ;
  • Lee, Shin Yup (Department of Internal Medicine, Kyungpook National University School of Medicine) ;
  • Lim, Jeong Ok (Bio-Medical Research Institute, Kyungpook National University School of Medicine) ;
  • Park, Jae Yong (Department of Internal Medicine, Kyungpook National University School of Medicine)
  • Received : 2013.04.24
  • Accepted : 2013.06.29
  • Published : 2013.10.10
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Abstract

Recently, rearranged during transfection (RET) fusions have been identified in approximately 1% of non-small cell lung cancer (NSCLC). To know the prevalence of RET fusion genes in Korean NSCLCs, we examined the RET fusion genes in 156 surgically resected NSCLCs using a reverse transcriptase polymerase chain reaction. Two KIF5B-RET fusions and one CCDC6-RET fusion were identified. All three patients were females and never smokers with adenocarcinomas. RET fusion genes were mutually exclusive from EGFR, KRAS mutations and EML4-ALK fusion. RET fusion genes occur 1.9% (3 of 156) of surgically treated NSCLC patients in Koreans.

Keywords

References

  1. Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA. Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. Mayo Clin Proc 2008; 83: 584-94. https://doi.org/10.1016/S0025-6196(11)60735-0
  2. Goffin J, Lacchetti C, Ellis PM, Ung YC, Evans WK; Lung Cancer Disease Site Group of Cancer Care Ontario's Program in Evidence-Based Care. First-line systemic chemotherapy in the treatment of advanced nonsmall cell lung cancer: a systematic review. J Thorac Oncol 2010; 5: 260-74. https://doi.org/10.1097/JTO.0b013e3181c6f035
  3. Sequist LV, Martins RG, Spigel D, Grunberg SM, Spira A, Janne PA, Joshi VA, McCollum D, Evans TL, Muzikansky A, et al. First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations. J Clin Oncol 2008; 26: 2442-9. https://doi.org/10.1200/JCO.2007.14.8494
  4. Kwak EL, Bang YJ, Camidge DR, Shaw AT, Solomon B, Maki RG, Ou SH, Dezube BJ, Janne PA, Costa DB, et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med 2010; 363: 1693-703. https://doi.org/10.1056/NEJMoa1006448
  5. Takeuchi K, Soda M, Togashi Y, Suzuki R, Sakata S, Hatano S, Asaka R, Hamanaka W, Ninomiya H, Uehara H, et al. RET, ROS1 and ALK fusions in lung cancer. Nat Med 2012; 18: 378-81. https://doi.org/10.1038/nm.2658
  6. Lipson D, Capelletti M, Yelensky R, Otto G, Parker A, Jarosz M, Curran JA, Balasubramanian S, Bloom T, Brennan KW, et al. Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies. Nat Med 2012; 18: 382-4. https://doi.org/10.1038/nm.2673
  7. Wang R, Hu H, Pan Y, Li Y, Ye T, Li C, Luo X, Wang L, Li H, Zhang Y, et al. RET fusions define a unique molecular and clinicopathologic subtype of non-small-cell lung cancer. J Clin Oncol 2012; 30: 4352-9. https://doi.org/10.1200/JCO.2012.44.1477
  8. Matsubara D, Kanai Y, Ishikawa S, Ohara S, Yoshimoto T, Sakatani T, Oguni S, Tamura T, Kataoka H, Endo S, et al. Identification of CCDC6-RET fusion in the human lung adenocarcinoma cell line, LC-2/ad. J Thorac Oncol 2012; 7: 1872-6. https://doi.org/10.1097/JTO.0b013e3182721ed1
  9. Kohno T, Ichikawa H, Totoki Y, Yasuda K, Hiramoto M, Nammo T, Sakamoto H, Tsuta K, Furuta K, Shimada Y, et al. KIF5B-RET fusions in lung adenocarcinoma. Nat Med 2012; 18: 375-7. https://doi.org/10.1038/nm.2644
  10. Eng C. RET proto-oncogene in the development of human cancer. J Clin Oncol 1999; 17: 380-93. https://doi.org/10.1200/JCO.1999.17.1.380
  11. Bounacer A, Wicker R, Caillou B, Cailleux AF, Sarasin A, Schlumberger M, Suarez HG. High prevalence of activating ret proto-oncogene rearrangements, in thyroid tumors from patients who had received external radiation. Oncogene 1997; 15: 1263-73. https://doi.org/10.1038/sj.onc.1200206
  12. Chao BH, Briesewitz R, Villalona-Calero MA. RET fusion genes in nonsmall- cell lung cancer. J Clin Oncol 2012; 30: 4439-41. https://doi.org/10.1200/JCO.2012.45.8240
  13. Pao W, Hutchinson KE. Chipping away at the lung cancer genome. Nat Med 2012; 18: 349-51. https://doi.org/10.1038/nm.2697
  14. Lee SY, Kim MJ, Jin G, Yoo SS, Park JY, Choi JE, Jeon HS, Cho S, Lee EB, Cha SI, et al. Somatic mutations in epidermal growth factor receptor signaling pathway genes in non-small cell lung cancers. J Thorac Oncol 2010; 5: 1734-40. https://doi.org/10.1097/JTO.0b013e3181f0beca
  15. Ju YS, Lee WC, Shin JY, Lee S, Bleazard T, Won JK, Kim YT, Kim JI, Kang JH, Seo JS. A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing. Genome Res 2012; 22: 436-45. https://doi.org/10.1101/gr.133645.111

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