Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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The Protective Effect of Mineral Water Against UVB Irradiation

미네랄워터의 피부 장벽 보호 효과 연구

  • 이성훈 ((주)아모레퍼시픽 기술연구원 피부과학연구소) ;
  • 민대진 ((주)아모레퍼시픽 기술연구원 피부과학연구소) ;
  • 나용주 ((주)아모레퍼시픽 기술연구원 피부과학연구소) ;
  • 심종원 ((주)아모레퍼시픽 기술연구원 피부과학연구소) ;
  • 권이경 ((주)아모레퍼시픽 기술연구원 화장품연구소) ;
  • 조준철 ((주)아모레퍼시픽 기술연구원 피부과학연구소) ;
  • 이해광 ((주)아모레퍼시픽 기술연구원 피부과학연구소)
  • Received : 2012.08.16
  • Accepted : 2012.11.24
  • Published : 2013.03.31
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Abstract

Bicationic minerals such as calcium and magnesium are known to protect the skin barrier. The principal objective of this study was to evaluate the skin barrier protective effects of mineral water, which is composed of calcium, magnesium, manganese, and fluorine. UVB irradiation induces a destruction of tight junction (TJ) components. The TJ permeability barrier was also disrupted by UVB irradiation. We employed a skin equivalent model to assess the efficacy of mineral water in this regard. Mineral water maintained the structure of the skin equivalents following UVB irradiation. The results of the TJ permeability assay showed that mineral water helped to maintain the TJ permeability barrier after UVB irradiation in skin equivalent model. Mineral water supported the structure of TJ components and restored the occludin protein level in differentiated normal human keratinocytes after UVB irradiation. In conclusion, we found out the protective effect of mineral water against UVB irradiation.

칼슘, 마그네슘과 같은 양이온은 피부 장벽을 보호하는 기능이 있다고 알려져 있다. 본 연구의 목적은 칼슘, 마그네슘, 망간, 불소로 이루어진 미네랄워터의 피부 장벽 보호 기능을 확인하기 위한 것이다. 피부가 자외선에 노출되게 되면 밀착연접(tight junction, TJ)이 파괴되며, 밀착연접으로 이루어진 피부 장벽도 손상 받게된다. 미네랄워터가 자외선에 의해 손상된 피부의 장벽기능을 보호할 수 있는지 평가하기 위해 인공피부 모델을 이용한 실험을 진행하였다. 인공피부에 자외선을 조사하고 미네랄워터를 처리하면 피부 장벽 손상을 막아준다. TJ permeability assay를 통하여 자외선 처리 시 손상된 밀착연접 장벽이 미네랄워터 처리에 의해 유지되는 것을 확인하였다. 각질형성세포를 이용한 실험에서 미네랄워터가 밀착연접 구조를 유지시켜 주고, 자외선에 의해 감소된 occludin 단백질의 생성량이 회복되는 것을 확인하였다. 따라서 본 연구를 통해 미네랄워터는 자외선에 의한 피부 장벽 파괴를 막아주는 효과가 있음을 확인할 수 있었다.

Keywords

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