Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
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Association between oxidative stress and blood pressure in Korean subclinical hypertensive patients

경계성 고혈압 환자에서 혈압과 산화 스트레스 관련 지표 간의 상관성에 관한 연구

  • Han, Jeong-Hwa (Department of Food & Nutrition, College of Life Science and Nano Technology, Hannam University) ;
  • Lee, Hye-Jin (Department of Food & Nutrition, College of Life Science and Nano Technology, Hannam University) ;
  • Choi, Hee Jeong (Department of Family Medicine, Eulji University Hospital, Eulji University School of Medicine) ;
  • Yun, Kyung Eun (Health Screening Center, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine) ;
  • Kang, Myung-Hee (Department of Food & Nutrition, College of Life Science and Nano Technology, Hannam University)
  • 한정화 (한남대학교 생명나노과학대학 식품영양학과) ;
  • 이혜진 (한남대학교 생명나노과학대학 식품영양학과) ;
  • 최희정 (을지대학교병원 가정의학과) ;
  • 윤경은 (성균관대학교 의과대학 강북삼성병원 종합검진센터) ;
  • 강명희 (한남대학교 생명나노과학대학 식품영양학과)
  • Received : 2013.02.19
  • Accepted : 2013.04.12
  • Published : 2013.04.30
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Abstract

This study was conducted in order to investigate the association between hypertension and oxidative stress-related parameters and to evaluate these parameters in subclinical hypertensive patients and normotensive subjects living in Korea. We attempted to determine whether oxidative stress-related parameters would differ between two groups of 227 newly-diagnosed, untreated (systolic blood pressure (BP) ${\geq}$ 130 mmHg and diastolic BP ${\geq}$ 85 mmHg) and 130 normotensive subjects (systolic BP < 120 mmHg and diastolic BP < 80 mmHg). General characteristics of the subjects were collected using a simple questionnaire. From subjects' blood, degree of DNA damage in lymphocytes, the activities of erythrocyte superoxide dismutase, catalase, and glutathione peroxidase, level of plasma total radical-trapping antioxidant potential (TRAP), glutathione, and anti-oxidative vitamins, as well as plasma lipid profiles and conjugated diene (CD) were analyzed. Evaluation of the associations of oxidative stress-related parameters with blood pressure of the subjects was performed using Pearson partial correlation and multivariate logistic regression analysis after adjusting for confounding factors. Several oxidative stress-related parameters were higher in subclinical hypertensive patients than in normotensive subjects. Plasma levels of ${\alpha}$-tocopherol, ${\beta}$-carotene, TRAP, and activity of GSH-px were significantly lower in subclinical hypertensive patients than in normotensive subjects. Increased levels of DNA damage, lipid peroxidation, triglyceride, total cholesterol, and LDL-cholesterol were observed in subclinical hypertensive patients. These results confirm an association between blood pressure and oxidative stress-related parameters and suggest that the pathogenic role of oxidative stress in hypertension might be significant.

Keywords

References

  1. Narayan KM, Ali MK, Koplan JP. Global noncommunicable diseases-- where worlds meet. N Engl J Med 2010; 363(13): 1196-1198 https://doi.org/10.1056/NEJMp1002024
  2. Ministry of Health and Welfare, Korea Centers for Disease Control and Prevention. Korea Health Statistics 2010: Korea National Health and Nutrition Examination Survey (KNHANES V-1). Cheongwon: Korea Centers for Disease Control and Prevention; 2011
  3. Harris DM, Cohn HI, Pesant S, Eckhart AD. GPCR signalling in hypertension: role of GRKs. Clin Sci (Lond) 2008; 115(3): 79-89 https://doi.org/10.1042/CS20070442
  4. Ceriello A. Possible role of oxidative stress in the pathogenesis of hypertension. Diabetes Care 2008; 31 Suppl 2: S181-S184 https://doi.org/10.2337/dc08-s245
  5. Touyz RM. Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension: what is the clinical significance? Hypertension 2004; 44(3): 248-252 https://doi.org/10.1161/01.HYP.0000138070.47616.9d
  6. Zicha J, Dobesová Z, Kunes J. Relative deficiency of nitric oxidedependent vasodilation in salt-hypertensive Dahl rats: the possible role of superoxide anions. J Hypertens 2001; 19(2): 247-254 https://doi.org/10.1097/00004872-200102000-00011
  7. Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, Deanfield J, Drexler H, Gerhard-Herman M, Herrington D, Vallance P, Vita J, Vogel R; International Brachial Artery Reactivity Task Force. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 2002; 39(2): 257- 265
  8. Touyz RM, Yao G, Quinn MT, Pagano PJ, Schiffrin EL. p47phox associates with the cytoskeleton through cortactin in human vascular smooth muscle cells: role in NAD(P)H oxidase regulation by angiotensin II. Arterioscler Thromb Vasc Biol 2005; 25(3): 512-518 https://doi.org/10.1161/01.ATV.0000154141.66879.98
  9. Bessa SS, Ali EM, Hamdy SM. The role of glutathione S-transferase M1 and T1 gene polymorphisms and oxidative stress-related parameters in Egyptian patients with essential hypertension. Eur J Intern Med 2009; 20(6): 625-630 https://doi.org/10.1016/j.ejim.2009.06.003
  10. Touyz RM, Briones AM. Reactive oxygen species and vascular biology: implications in human hypertension. Hypertens Res 2011; 34(1): 5-14 https://doi.org/10.1038/hr.2010.201
  11. Gur M, Yildiz A, Demirbag R, Yilmaz R, Koçyigit A, Celik H, Aksoy N. Relationship between left ventricle geometric patterns and lymphocyte DNA damage in patients with untreated essential hypertension. Clin Biochem 2007; 40(7): 454-459 https://doi.org/10.1016/j.clinbiochem.2006.10.024
  12. Chen J, He J, Hamm L, Batuman V, Whelton PK. Serum antioxidant vitamins and blood pressure in the United States population. Hypertension 2002; 40(6): 810-816 https://doi.org/10.1161/01.HYP.0000039962.68332.59
  13. Chen X, Touyz RM, Park JB, Schiffrin EL. Antioxidant effects of vitamins C and E are associated with altered activation of vascular NADPH oxidase and superoxide dismutase in stroke-prone SHR. Hypertension 2001; 38(3 Pt 2): 606-611 https://doi.org/10.1161/hy09t1.094005
  14. Boshtam M, Rafiei M, Sadeghi K, Sarraf-Zadegan N. Vitamin E can reduce blood pressure in mild hypertensives. Int J Vitam Nutr Res 2002; 72(5): 309-314 https://doi.org/10.1024/0300-9831.72.5.309
  15. Han SJ, Park SH. The changes of antioxidant enzymes in the erythrocytes and placentas from patient with pregnancy-induced hypertension. Korean J Obstet Gynecol 1996; 39(3): 511-518
  16. Kim JH, Kim MJ, Kwak HK. Obesity indices and plasma total antioxidant status in hypertensive elderly living in Ulsan area. Korean J Community Nutr 2006; 11(2): 279-288
  17. Park EJ, Kim JS, Jeon EJ, Kim HY, Park YK, Kang MH. The effects of purple grape juice supplementation on improvement of antioxidant status and lymphocyte DNA damage in Korean smokers. Korean J Nutr 2004; 37(4): 281-290
  18. Lee HJ, Park YK, Kang MH. The effect of carrot juice, $\beta$-carotene supplementation on lymphocyte DNA damage, erythrocyte antioxidant enzymes and plasma lipid profiles in Korean smoker. Nutr Res Pract 2011; 5(6): 540-547 https://doi.org/10.4162/nrp.2011.5.6.540
  19. Appel LJ, Moore TJ, Obarzanek E, Vollmer WM, Svetkey LP, Sacks FM, Bray GA, Vogt TM, Cutler JA, Windhauser MM, Lin PH, Karanja N. A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med 1997; 336(16): 1117-1124 https://doi.org/10.1056/NEJM199704173361601
  20. Lassègue B, Griendling KK. Reactive oxygen species in hypertension; an update. Am J Hypertens 2004; 17(9): 852-860 https://doi.org/10.1016/j.amjhyper.2004.02.004
  21. Rodrigo R, Prat H, Passalacqua W, Araya J, Guichard C, Bächler JP. Relationship between oxidative stress and essential hypertension. Hypertens Res 2007; 30(12): 1159-1167 https://doi.org/10.1291/hypres.30.1159
  22. Ulker S, McKeown PP, Bayraktutan U. Vitamins reverse endothelial dysfunction through regulation of eNOS and NAD(P)H oxidase activities. Hypertension 2003; 41(3): 534-539 https://doi.org/10.1161/01.HYP.0000057421.28533.37
  23. Pezeshk A, Derick Dalhouse A. Vitamin E, membrane fluidity, and blood pressure in hypertensive and normotensive rats. Life Sci 2000; 67(15): 1881-1889 https://doi.org/10.1016/S0024-3205(00)00775-X
  24. Russo C, Olivieri O, Girelli D, Faccini G, Zenari ML, Lombardi S, Corrocher R. Anti-oxidant status and lipid peroxidation in patients with essential hypertension. J Hypertens 1998; 16(9): 1267- 1271 https://doi.org/10.1097/00004872-199816090-00007
  25. Tse WY, Maxwell SR, Thomason H, Blann A, Thorpe GH, Waite M, Holder R. Antioxidant status in controlled and uncontrolled hypertension and its relationship to endothelial damage. J Hum Hypertens 1994; 8(11): 843-849
  26. Miller ER 3rd, Appel LJ, Levander OA, Levine DM. The effect of antioxidant vitamin supplementation on traditional cardiovascular risk factors. J Cardiovasc Risk 1997; 4(1): 19-24 https://doi.org/10.1177/174182679700400104
  27. Fotherby MD, Williams JC, Forster LA, Craner P, Ferns GA. Effect of vitamin C on ambulatory blood pressure and plasma lipids in older persons. J Hypertens 2000; 18(4): 411-415 https://doi.org/10.1097/00004872-200018040-00009
  28. Block G, Mangels AR, Norkus EP, Patterson BH, Levander OA, Taylor PR. Ascorbic acid status and subsequent diastolic and systolic blood pressure. Hypertension 2001; 37(2): 261-267 https://doi.org/10.1161/01.HYP.37.2.261
  29. Palumbo G, Avanzini F, Alli C, Roncaglioni MC, Ronchi E, Cristofari M, Capra A, Rossi S, Nosotti L, Costantini C, Cavalera C. Effects of vitamin E on clinic and ambulatory blood pressure in treated hypertensive patients. Collaborative Group of the Primary Prevention Project (PPP)--Hypertension study. Am J Hypertens 2000; 13(5 Pt 1): 564-567 https://doi.org/10.1016/S0895-7061(00)00244-2
  30. Ward NC, Croft KD. Hypertension and oxidative stress. Clin Exp Pharmacol Physiol 2006; 33(9): 872-876 https://doi.org/10.1111/j.1440-1681.2006.04457.x
  31. Kim MK, Sasaki S, Sasazuki S, Okubo S, Hayashi M, Tsugane S. Lack of long-term effect of vitamin C supplementation on blood pressure. Hypertension 2002; 40(6): 797-803 https://doi.org/10.1161/01.HYP.0000038339.67450.60
  32. Bae I, Fan S, Meng Q, Rih JK, Kim HJ, Kang HJ, Xu J, Goldberg ID, Jaiswal AK, Rosen EM. BRCA1 induces antioxidant gene expression and resistance to oxidative stress. Cancer Res 2004; 64 (21): 7893-7909 https://doi.org/10.1158/0008-5472.CAN-04-1119
  33. Simic DV, Mimic-Oka J, Pljesa-Ercegovac M, Savic-Radojevic A, Opacic M, Matic D, Ivanovic B, Simic T. Byproducts of oxidative protein damage and antioxidant enzyme activities in plasma of patients with different degrees of essential hypertension. J Hum Hypertens 2006; 20(2): 149-155 https://doi.org/10.1038/sj.jhh.1001945
  34. Pedro-Botet J, Covas MI, Martin S, Rubies-Prat J. Decreased endogenous antioxidant enzymatic status in essential hypertension. J Hum Hypertens 2000; 14(6): 343-345 https://doi.org/10.1038/sj.jhh.1001034
  35. Kasapoglu M, Ozben T. Alterations of antioxidant enzymes and oxidative stress markers in aging. Exp Gerontol 2001; 36(2): 209- 220 https://doi.org/10.1016/S0531-5565(00)00198-4
  36. Kang MH, Yun JS. The effects of exercise and other relating factors on the activity of erythrocyte antioxidant enzymes and plasma TRAP levles in male college students. Korean J Nutr 2002; 35 (1): 30-36
  37. Vasconcelos SM, Goulart MO, Silva MA, Manfredini V, Benfato Mda S, Rabelo LA, Fontes G. Markers of redox imbalance in the blood of hypertensive patients of a community in Northeastern Brazil. Arq Bras Cardiol 2011; 97(2): 141-147
  38. Kesavulu MM, Rao BK, Giri R, Vijaya J, Subramanyam G, Apparao C. Lipid peroxidation and antioxidant enzyme status in Type 2 diabetics with coronary heart disease. Diabetes Res Clin Pract 2001; 53(1): 33-39 https://doi.org/10.1016/S0168-8227(01)00238-8
  39. Turk HM, Sevinc A, Camci C, Cigli A, Buyukberber S, Savli H, Bayraktar N. Plasma lipid peroxidation products and antioxidant enzyme activities in patients with type 2 diabetes mellitus. Acta Diabetol 2002; 39(3): 117-122 https://doi.org/10.1007/s005920200029
  40. Halliwell B, Aruoma OI. DNA damage by oxygen-derived species. Its mechanism and measurement in mammalian systems. FEBS Lett 1991; 281(1-2): 9-19 https://doi.org/10.1016/0014-5793(91)80347-6
  41. Yildiz A, Gur M, Yilmaz R, Demirbag R, Celik H, Aslan M, Kocyigit A. Lymphocyte DNA damage and total antioxidant status in patients with white-coat hypertension and sustained hypertension. Turk Kardiyol Dern Ars 2008; 36(4): 231-238
  42. Lacy F, Kailasam MT, O'Connor DT, Schmid-Schonbein GW, Parmer RJ. Plasma hydrogen peroxide production in human essential hypertension: role of heredity, gender, and ethnicity. Hypertension 2000; 36(5): 878-884 https://doi.org/10.1161/01.HYP.36.5.878
  43. Kumar KV, Das UN. Are free radicals involved in the pathobiology of human essential hypertension? Free Radic Res Commun 1993; 19(1): 59-66 https://doi.org/10.3109/10715769309056499
  44. Ward NC, Hodgson JM, Puddey IB, Mori TA, Beilin LJ, Croft KD. Oxidative stress in human hypertension: association with antihypertensive treatment, gender, nutrition, and lifestyle. Free Radic Biol Med 2004; 36(2): 226-232 https://doi.org/10.1016/j.freeradbiomed.2003.10.021
  45. Cracowski JL, Baguet JP, Ormezzano O, Bessard J, Stanke- Labesque F, Bessard G, Mallion JM. Lipid peroxidation is not increased in patients with untreated mild-to-moderate hypertension. Hypertension 2003; 41(2): 286-288 https://doi.org/10.1161/01.HYP.0000050963.16405.E6
  46. Gunes F, Akbal E, Cakir E, Akyurek O, Altunbas M, Ozbek M. Visfatin may be a novel marker for identifying stages of essential hypertension in advanced age patients. Intern Med 2012; 51(6): 553-557 https://doi.org/10.2169/internalmedicine.51.6609
  47. Zheng M, Zeng Q, Shi XQ, Zhao J, Tang CS, Sun NL, Geng B. Erythrocytic or serum hydrogen sulfide association with hypertension development in untreated essential hypertension. Chin Med J (Engl) 2011; 124(22): 3693-3701
  48. Drummond GR, Selemidis S, Griendling KK, Sobey CG. Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets. Nat Rev Drug Discov 2011; 10(6): 453-471 https://doi.org/10.1038/nrd3403

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