Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Hotwater Extract of Hovenia dulcis Peduncle Improves Exercise Performance and Anti-fatigue Effect in Mice

헛개나무 열매 열수추출물 투여에 의한 생쥐의 지구력 운동 수행 능력 향상 및 피로개선 효과

  • Na, Chun-Soo (Lifetree Biotechnology Institute, Lifetree Biotech Co. Ltd.) ;
  • Hong, Cheol Yi (Lifetree Biotechnology Institute, Lifetree Biotech Co. Ltd.) ;
  • Na, Dae-Seung (School of Life sciences and Biotechnology, Korea University) ;
  • Kim, Jin Beom (Lifetree Biotechnology Institute, Lifetree Biotech Co. Ltd.) ;
  • Yoon, Sun Young (Lifetree Biotechnology Institute, Lifetree Biotech Co. Ltd.) ;
  • Lee, Sang-Bum (School of Life sciences and Biotechnology, Korea University) ;
  • Dong, Mi-Sook (School of Life sciences and Biotechnology, Korea University)
  • Received : 2013.03.06
  • Accepted : 2013.03.12
  • Published : 2013.03.31
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Abstract

The aim of this study was to evaluate the effect of hot water extract of peduncle obtained from Hovenia dulcis Thunb (HD) which is commercially developed for the protective effect on the alcoholic hepatotoxicity, on the endurance capacity for weight loaded forced swimming mice. The swimming times to exhaustion in mice fed 100 and 200 mg/kg HD for 2 weeks were prolonged 3.6 and 3.7 fold, and for 4 weeks 1.9 and 2.7 fold compared with each vehicle control ($42.8{\pm}20.5$ min and $67.7{\pm}47.8$ min, for 2 and 4 weeks), respectively. Blood biochemical parameters for ALT, AST, creatinine and BUN were not significantly different between from HD fed or control mice. Although HD fed mice swam over 2 fold longer time than vehicle control mice at 4 weeks, blood biomarkers of physical fatigue such as glucose, triglyceride and free fatty acid, lactate were not significant different and even tended to ameliorate. Hepatic lipid peroxidation and SOD activity did not significantly change in HD fed- and vehicle control exhausted swimming mice at 2 or 4 weeks. However, catalase activity in HD-fed mice was significantly increased in a dose-dependent manner compared with vehicle control mice. The present study indicates that HD improved physical fatigue and exercise performance in mice. Therefore, it has a potential for the pharmacological effect of anti-fatigue.

Keywords

References

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