Experimental and Molecular Medicine

Korean Society for Biochemistry and Molecular Biongy (생화학분자생물학회)
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Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine

  • Murphy, Matthew B (Celling Biosciences) ;
  • Moncivais, Kathryn (Celling Biosciences) ;
  • Caplan, Arnold I. (Department of Biology, Skeletal Research Center, Case Western Reserve University)
  • Published : 2013.11.30
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Abstract

Mesenchymal stem cells (MSCs) are partially defined by their ability to differentiate into tissues including bone, cartilage and adipose in vitro, but it is their trophic, paracrine and immunomodulatory functions that may have the greatest therapeutic impact in vivo. Unlike pharmaceutical treatments that deliver a single agent at a specific dose, MSCs are site regulated and secrete bioactive factors and signals at variable concentrations in response to local microenvironmental cues. Significant progress has been made in understanding the biochemical and metabolic mechanisms and feedback associated with MSC response. The anti-inflammatory and immunomodulatory capacity of MSC may be paramount in the restoration of localized or systemic conditions for normal healing and tissue regeneration. Allogeneic MSC treatments, categorized as a drug by regulatory agencies, have been widely pursued, but new studies demonstrate the efficacy of autologous MSC therapies, even for individuals affected by a disease state. Safety and regulatory concerns surrounding allogeneic cell preparations make autologous and minimally manipulated cell therapies an attractive option for many regenerative, anti-inflammatory and autoimmune applications.

Keywords

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  26. CXCL14 and MCP1 are potent trophic factors associated with cell migration and angiogenesis leading to higher regenerative potential of dental pulp side population cells vol.6, pp.None, 2013, https://doi.org/10.1186/s13287-015-0088-z
  27. Transplantation of mesenchymal stem cells ameliorates secondary osteoporosis through interleukin-17-impaired functions of recipient bone marrow mesenchymal stem cells in MRL/ lpr mice vol.6, pp.None, 2013, https://doi.org/10.1186/s13287-015-0091-4
  28. Efficacy of autologous stem cell-based therapy for osteonecrosis of the femoral head in sickle cell disease: a five-year follow-up study vol.6, pp.None, 2013, https://doi.org/10.1186/s13287-015-0105-2
  29. Adipose tissue-derived mesenchymal stem cells and platelet-rich plasma: stem cell transplantation methods that enhance stemness vol.6, pp.1, 2013, https://doi.org/10.1186/s13287-015-0217-8
  30. Neural and mesenchymal stem cells in animal models of Huntington’s disease: past experiences and future challenges vol.6, pp.1, 2015, https://doi.org/10.1186/s13287-015-0248-1
  31. The Role of Wharton’s Jelly Mesenchymal Stem Cells in Skin Reconstruction vol.2, pp.2, 2013, https://doi.org/10.17795/jssc30347
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  35. Use of Adipose-Derived Mesenchymal Stem Cells in Keratoconjunctivitis Sicca in a Canine Model vol.2015, pp.None, 2013, https://doi.org/10.1155/2015/527926
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  38. DNA methyltransferase inhibition accelerates the immunomodulation and migration of human mesenchymal stem cells vol.5, pp.None, 2013, https://doi.org/10.1038/srep08020
  39. hiPS-MSCs differentiation towards fibroblasts on a 3D ECM mimicking scaffold vol.5, pp.None, 2013, https://doi.org/10.1038/srep08480
  40. Influence of age on rat bone-marrow mesenchymal stem cells potential vol.5, pp.None, 2015, https://doi.org/10.1038/srep16765
  41. Adult mesenchymal stem cells and women’s health vol.22, pp.2, 2015, https://doi.org/10.1097/gme.0000000000000408
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  48. Connexin43 Mediated Delivery of ADAMTS5 Targeting siRNAs from Mesenchymal Stem Cells to Synovial Fibroblasts vol.10, pp.6, 2015, https://doi.org/10.1371/journal.pone.0129999
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  50. Melatonin pretreatment of human adipose tissue-derived mesenchymal stromal cells enhances their prosurvival and protective effects on human kidney cells vol.308, pp.12, 2013, https://doi.org/10.1152/ajprenal.00512.2014
  51. Down-regulation of the autophagy gene, ATG7 , protects bone marrow-derived mesenchymal stem cells from stressful conditions vol.50, pp.2, 2013, https://doi.org/10.5045/br.2015.50.2.80
  52. The Therapeutic Effects of Optimal Dose of Mesenchymal Stem Cells in a Murine Model of an Elastase Induced-Emphysema vol.78, pp.3, 2013, https://doi.org/10.4046/trd.2015.78.3.239
  53. Transcriptional profiling of interleukin-2-primed human adipose derived mesenchymal stem cells revealed dramatic changes in stem cells response imposed by replicative senescence vol.6, pp.20, 2015, https://doi.org/10.18632/oncotarget.4852
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  56. ASC Spheroid Geometry and Culture Oxygenation Differentially Impact Induction of Preangiogenic Behaviors in Endothelial Cells vol.24, pp.11, 2013, https://doi.org/10.3727/096368914x684051
  57. In Vivo Tracking and Fate of Intra-Articularly Injected Superparamagnetic Iron Oxide Particle-Labeled Multipotent Stromal Cells in an Ovine Model of Osteoarthritis vol.24, pp.11, 2015, https://doi.org/10.3727/096368914x685654
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  60. Antifibrotic, Antioxidant, and Immunomodulatory Effects of Mesenchymal Stem Cells in HOCl‐Induced Systemic Sclerosis vol.68, pp.4, 2013, https://doi.org/10.1002/art.39477
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  83. Acute stimulation of mesenchymal stem cells with cigarette smoke extract affects their migration, differentiation, and paracrine potential vol.6, pp.None, 2013, https://doi.org/10.1038/srep22957
  84. PGE 2 maintains self-renewal of human adult stem cells via EP2-mediated autocrine signaling and its production is regulated by cell-to-cell contact vol.6, pp.None, 2013, https://doi.org/10.1038/srep26298
  85. Cryopreserved Mesenchymal Stromal Cells Maintain Potency in a Retinal Ischemia/Reperfusion Injury Model: Toward an off-the-shelf Therapy vol.6, pp.None, 2013, https://doi.org/10.1038/srep26463
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  87. Delivery of human mesenchymal adipose‐derived stem cells restores multiple urological dysfunctions in a rat model mimicking radical prostatectomy damages through tissue‐specific paracrine vol.34, pp.2, 2013, https://doi.org/10.1002/stem.2226
  88. Adipose-derived mesenchymal stem cells from infrapatellar fat pad of patients with rheumatoid arthritis and osteoarthritis have comparable immunomodulatory properties vol.49, pp.2, 2013, https://doi.org/10.3109/08916934.2015.1113267
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  90. MIRO GTPases in Mitochondrial Transport, Homeostasis and Pathology vol.5, pp.1, 2016, https://doi.org/10.3390/cells5010001
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  95. Endometrial mesenchymal stem cells as a cell based therapy for pelvic organ prolapse vol.8, pp.5, 2013, https://doi.org/10.4252/wjsc.v8.i5.202
  96. The Quest toward limb regeneration: a regenerative engineering approach vol.3, pp.2, 2013, https://doi.org/10.1093/rb/rbw002
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  98. Adenoviral vector encoding soluble Flt-1 engineered human endometrial mesenchymal stem cells effectively regress endometriotic lesions in NOD/SCID mice vol.23, pp.7, 2013, https://doi.org/10.1038/gt.2016.30
  99. Autophagy-Modulated Human Bone Marrow-Derived Mesenchymal Stem Cells Accelerate Liver Restoration in Mouse Models of Acute Liver Failure vol.20, pp.3, 2013, https://doi.org/10.7508/ibj.2016.03.002
  100. Dental mesenchymal stem cells vol.143, pp.13, 2016, https://doi.org/10.1242/dev.134189
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  112. Gene Profiles in a Smoke-Induced COPD Mouse Lung Model Following Treatment with Mesenchymal Stem Cells vol.39, pp.10, 2013, https://doi.org/10.14348/molcells.2016.0095
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  141. Mesenchymal Stromal Cell-Derived Microvesicles Regulate an Internal Pro-Inflammatory Program in Activated Macrophages vol.8, pp.None, 2017, https://doi.org/10.3389/fimmu.2017.00881
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  164. Endothelial-derived extracellular matrix ameliorate the stemness deprivation during ex vivo expansion of mouse bone marrow-derived mesenchymal stem cells vol.12, pp.8, 2013, https://doi.org/10.1371/journal.pone.0184111
  165. Influence of HLA Matching on the Efficacy of Allogeneic Mesenchymal Stromal Cell Therapies for Osteoarthritis and Degenerative Disc Disease vol.3, pp.9, 2017, https://doi.org/10.1097/txd.0000000000000724
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  167. Acceleration of Fracture Healing by Overexpression of Basic Fibroblast Growth Factor in the Mesenchymal Stromal Cells vol.6, pp.10, 2013, https://doi.org/10.1002/sctm.17-0039
  168. Therapeutic potential of mesenchymal stem cells for diabetes vol.59, pp.3, 2013, https://doi.org/10.1530/jme-17-0117
  169. Can regenerative medicine and nanotechnology combine to heal wounds? The search for the ideal wound dressing vol.12, pp.19, 2017, https://doi.org/10.2217/nnm-2017-0173
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  171. Cell-based therapeutic strategies for multiple sclerosis vol.140, pp.11, 2013, https://doi.org/10.1093/brain/awx154
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  209. The Role of miR-126 in Critical Limb Ischemia Treatment Using Adipose-Derived Stem Cell Therapeutic Factor Concentrate and Extracellular Matrix Microparticles vol.24, pp.None, 2018, https://doi.org/10.12659/msm.905442
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