Journal of Korean Medical Science

Korean Acad Medical Sciences (대한의학회)
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Risk Factors for Acute Hepatitis A Infection in Korea in 2007 and 2009: A Case-Control Study

  • Seo, Joo Youn (Department of Preventive Medicine/Institute of Community Health, Hanyang University, College of Medicine) ;
  • Choi, Bo Youl (Department of Preventive Medicine/Institute of Community Health, Hanyang University, College of Medicine) ;
  • Ki, Moran (Department of Preventive Medicine, Eulji University, School of Medicine) ;
  • Jang, Hye Lim (Department of Preventive Medicine/Institute of Community Health, Hanyang University, College of Medicine) ;
  • Park, Hee Suk (Department of Preventive Medicine/Institute of Community Health, Hanyang University, College of Medicine) ;
  • Son, Hyun Jin (Division of Public Health Crisis Response, Korea Centers for Disease Control and Prevention) ;
  • Bae, Si Hyun (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Kang, Jin Han (Department of Pediatrics, The Catholic University of Korea College of Medicine) ;
  • Jun, Dae Won (Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Lee, Jin-Woo (Department of Internal Medicine, Inha University School of Medicine) ;
  • Hong, Young Jin (Department of Pediatrics, Inha University School of Medicine) ;
  • Kim, Young Seok (Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine) ;
  • Kim, Chang-Hwi (Department of Pediatrics, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine) ;
  • Chang, U Im (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Kim, Jong-Hyun (Department of Pediatrics, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Yang, Hyeon Woong (Angel Internal Medicine Clinic) ;
  • Kim, Hong Soo (Department of Internal Medicine, Soonchunhyang University College of Medicine) ;
  • Park, Kyeong Bae (Department of Pediatrics, Soonchunhyang University College of Medicine) ;
  • Hwang, Jae Seok (Department of Internal Medicine, Keimyung University School of Medicine) ;
  • Heo, Jeong (Department of Internal Medicine, Pusan National University School of Medicine) ;
  • Kim, In Hee (Department of Internal Medicine, Chonbuk National Unversity Medical School and Hospital) ;
  • Kim, Jung Soo (Department of Pediatrics, Chonbuk National Unversity Medical School and Hospital) ;
  • Cheon, Gab Jin (Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine)
  • Published : 2013.06.10
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Abstract

This study aimed to identify the risk factors associated with acute hepatitis A virus (HAV) infection in the Korean population. Participants were recruited from five referral hospitals across the country in 2007 and from 11 hospitals in 2009. Patients with positive anti-HAV IgM antibody tests became the case group, while patients treated for non-contagious diseases at the same hospitals were recruited as controls. A total of 222 and 548 case-control pairs were studied in the 2007 and 2009 surveys, respectively. Data from the surveys were analyzed jointly. In a multivariate analysis, sharing the household with HAV-infected family members (OR, 6.32; 95% CI, 1.4-29.6), contact with other HAV-infected individuals (OR, 4.73; 95% CI, 2.4-9.4), overseas travel in 2007 (OR, 19.93; 95% CI, 2.3-174.4), consumption of raw shellfish (OR, 2.51; 95% CI, 1.8-3.5), drinking bottled water (OR, 1.64; 95% CI, 1.3-8.4), and occupation that involve handling food (OR, 3.30; 95% CI, 1.3-8.4) increased the risk of HAV infection. Avoiding contact with HAV-infected individuals and avoiding raw foods eating could help minimize the risk of hepatitis A infection. Immunization must be beneficial to individuals who handle food ingredients occupationally or travel overseas to HAV-endemic areas.

Keywords

References

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