Abstract

Vitamin D is not only a nutrient, but also a hormone that affects the musculoskeletal system. Recently, extensive attention has been drawn to the autocrine and paracrine functions of vitamin D. Consequently, its extraskeletal effect and its known effects on the skeletal system have drawn particular interest. The socioeconomic development and aging of the population of Korea have also raised interest in dietary supplements. Because vitamin D deficiency is high among Koreans, both physicians and patients are questioning whether vitamin D supplements are needed. This review assessed the skeletal and extraskeletal efficacy of vitamin D with regard to mortality, cancer, cardiovascular disease, and diabetes via an evidence-based approach. The recent interest surrounding vitamin D can be expected to motivate many more studies on its effects and adverse effects, and accordingly, the level of evidence and recommendations will be adjusted. Clinicians should familiarize themselves with updated evidence about vitamin D, and must counsel patients with that evidence in mind.

Keywords

• Vitamin D;
• Evidence-based medicine;
• Accidental falls;
• Osteoporosis;
• Neoplasms;
• Mortality;
• Cardiovascular diseases

• 비타민 D;
• 근거중심의학;
• 낙상;
• 골다공증;
• 종양;
• 사망률;
• 심혈관질환;