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Stroke Statistics in Korea: Part I. Epidemiology and Risk Factors: A Report from the Korean Stroke Society and Clinical Research Center for Stroke

  • Hong, Keun-Sik (Department of Neurology, Ilsan Paik Hospital, Inje University College of Medicine) ;
  • Bang, Oh Young (Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kang, Dong-Wha (Department of Neurology, University of Ulsan College of Medicine) ;
  • Yu, Kyung-Ho (Department of Neurology, Hallym University College of Medicine) ;
  • Bae, Hee-Joon (Department of Neurology, Seoul National University College of Medicine) ;
  • Lee, Jin Soo (Department of Neurology, Ajou University School of Medicine) ;
  • Heo, Ji Hoe (Department of Neurology, Yonsei University College of Medicine) ;
  • Kwon, Sun U. (Department of Neurology, University of Ulsan College of Medicine) ;
  • Oh, Chang Wan (Department of Neurosurgery, Seoul National University College of Medicine) ;
  • Lee, Byung-Chul (Department of Neurology, Hallym University College of Medicine) ;
  • Kim, Jong S. (Department of Neurology, University of Ulsan College of Medicine) ;
  • Yoon, Byung-Woo (Department of Neurology, Seoul National University College of Medicine)
  • Published : 2013.01.31

Abstract

The aim of the Part I of Stroke Statistics in Korea is to summarize nationally representative data of the epidemiology and risk factors of stroke in a single document. Every year, approximately 105,000 people experience a new or recurrent stroke and more than 26,000 die of stroke, which indicates that every 5 minutes stroke attacks someone and every 20 minutes stroke kills someone in Korea. Stroke accounts for roughly 1 of every 10 deaths. The estimated stroke prevalence is about 795,000 in people aged ${\geq}30$ years. The nationwide total cost for stroke care was 3,737 billion Korean won (US$3.3 billion) in 2005. Fortunately, the annual stroke mortality rate decreased substantially by 28.3% during the first decade of the 21th century (53.2/100,000 in 2010). Among OECD countries, Korea had the lowest in-hospital 30-day case-fatality rate for ischemic stroke and ranked third lowest for hemorrhagic stroke in 2009. The proportion of ischemic stroke has steadily increased and accounted for 76% of all strokes in 2009. According to hospital registry studies, the 90-day mortality rate was 3-7% for ischemic stroke and 17% for intracerebral hemorrhage. For risk factors, among Korean adults ${\geq}30$ years of age, one in 3-4 has hypertension, one in 10 diabetes, and one in 7 hypercholesterolemia. One in 3 Korean adults ${\geq}19$ years of age is obese. Over the last 10 years, the prevalence of hypertension slightly decreased, but the prevalence of diabetes, hypercholesterolemia, and obesity increased. Smoking prevalence in men has decreased, but is still as high as 48%. This report could be a valuable resource for establishing health care policy and guiding future research directions.

Keywords

References

  1. Organization for Economic Cooperation and Development. OECD Economic Surveys: Korea 2010. OECD Web site http: //www.oecd.org/dataoecd/14/34/45432048.pdf. Accessed April 2011.
  2. Asplund K, Eriksson M, Persson O. Country comparisons of human stroke research since 2001. Stroke 2012;43:830-837. https://doi.org/10.1161/STROKEAHA.111.637249
  3. Korean Center for Disease Control. Construction of national surveillance system for cardiovascular & cerebrovascular diseases. 2006.
  4. Jung KH, Lee SH, Kim BJ, Yu KH, Hong KS, Lee BC, et al. Secular trends in ischemic stroke characteristics in a rapidly developed country: results from the Korean Stroke Registry Study (secular trends in Korean stroke). Circ Cardiovasc Qual Outcomes 2012;5:327-334. https://doi.org/10.1161/CIRCOUTCOMES.111.963736
  5. Korean Statistical Information Service (KOSIS). Population projections and summary indicator for Korea (Population items). http://kosis.kr/eng/database/database_001000.jsp?listid=A&subtitle=Population/Household. Accessed July 18, 2012.
  6. Korean Center for Disease Control. Development of strategy and action plans for major chronic diseases prevention and control. 2004.
  7. Korean Health Insurance Review & Assessment Service. Report of assessment for quality of acute stroke care in Korea, 2005.
  8. Korean Health Insurance Review & Assessment Service. Report of assessment for quality of acute stroke care in Korea, 2008.
  9. Korean Health Insurance Review & Assessment Service. Report of assessment for quality of acute stroke care in Korea, 2010.
  10. Han DH, Kang HS, Kim GK, Oh CW. Current status of stroke management in Korea. Jpn J Stroke 2002;24:295-304. https://doi.org/10.3995/jstroke.24.295
  11. Adams HP, Jr., Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 1993; 24:35-41. https://doi.org/10.1161/01.STR.24.1.35
  12. Ministry of Health & Welfare, Korea Center For Disease Control & Prevention. Korea Health Statistics 2005: Korea National Health and Nutrition Examination Survey (KNHANES III).
  13. Ministry of Health & Welfare, Korea Center For Disease Control & Prevention. Korea Health Statistics 2010: Korea National Health and Nutrition Examination Survey (KNHANES V).
  14. Korean Statistical Information Service (KOSIS). Annual Report on the Cause of Death Statistics 2010.
  15. Korean Statistical Information Service (KOSIS). Annual Report on the Cause of Death Statistics. http://kostat.go.kr/portal/ korea/kor_nw/2/6/2/index.board. Accessed July 18, 2012.
  16. Korean Center for Disease Control. Health Behavior and Chronic Disease Statistics 2005.
  17. OECD (2011), Health at a Glance 2011: OECD Indicators, OECD Publishing. http://dx.doi.org/10.1787/health_glance-2011-en.
  18. Duncan PW, Goldstein LB, Matchar D, Divine GW, Feussner J. Measurement of motor recovery after stroke. Outcome assessment and sample size requirements. Stroke 1992;23:1084-1089. https://doi.org/10.1161/01.STR.23.8.1084
  19. Lees KR, Bath PMW, Schellinger PD, Kerr DM, Fulton R, Hacke W, et al. Contemporary Outcome Measures in Acute Stroke Research. Stroke 2012;43:1163-1170. https://doi.org/10.1161/STROKEAHA.111.641423
  20. Kasner SE. Clinical interpretation and use of stroke scales. Lancet Neurol 2006;5:603-612. https://doi.org/10.1016/S1474-4422(06)70495-1
  21. Hong KS, Kang DW, Koo JS, Yu KH, Han MK, Cho YJ, et al. Impact of neurological and medical complications on 3-month outcomes in acute ischaemic stroke. European Journal of Neurology 2008;15:1324-1331. https://doi.org/10.1111/j.1468-1331.2008.02310.x
  22. Kim J, Song TJ, Park JH, Lee HS, Nam CM, Nam HS, et al. Different prognostic value of white blood cell subtypes in patients with acute cerebral infarction. Atherosclerosis 2012;222: 464-467. https://doi.org/10.1016/j.atherosclerosis.2012.02.042
  23. Ko Y, Han MK, Kim WJ, Kwon OK, Oh CW, Jung C, et al. Differences of mortality and dependence between stroke unit and general ward care in acute ischemic stroke patients. J Korean Neurol Assoc 2009;27:116-122.
  24. Kim KH. Predictors of 30-day mortality and 90-day functional recovery after primary intracerebral hemorrhage: hospital based multivariate analysis in 585 patients. J Korean Neurosurg Soc 2009;45:341-349. https://doi.org/10.3340/jkns.2009.45.6.341
  25. Murray CJ. Rethinking DALYs. In: Murray CJ, Lopez AD. The Global Burden of Disease. Cambridge, MA: Harvard University Press. 1996;1-98.
  26. Kim AS, Johnston SC. Global variation in the relative burden of stroke and ischemic heart disease. Circulation 2011;124:314-323. https://doi.org/10.1161/CIRCULATIONAHA.111.018820
  27. Johnston SC, Mendis S, Mathers CD. Global variation in stroke burden and mortality: estimates from monitoring, surveillance, and modelling. Lancet Neurol 2009;8:345-354. https://doi.org/10.1016/S1474-4422(09)70023-7
  28. Hong KS, Kim J, Cho YJ, Seo SY, Hwang SI, Kim SC, et al. Burden of ischemic stroke in Korea: analysis of disability-adjusted life years lost. J Clin Neurol 2011;7:77-84. https://doi.org/10.3988/jcn.2011.7.2.77
  29. Lim SJ, Kim HJ, Nam CM, Chang HS, Jang YH, Kim S, et al. Socioeconomic costs of stroke in Korea: estimated from the Korea national health insurance claims database. J Prev Med Public Health 2009;42:251-260. https://doi.org/10.3961/jpmph.2009.42.4.251
  30. Kang HY, Lim SJ, Suh HS, Liew D. Estimating the lifetime economic burden of stroke according to the age of onset in South Korea: a cost of illness study. BMC Public Health 2011; 11:646. https://doi.org/10.1186/1471-2458-11-646
  31. Lewington S, Clarke R, Qizilbash N, Peto R, Collins R. Agespecific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 2002;360:1903-1913. https://doi.org/10.1016/S0140-6736(02)11911-8
  32. Psaty BM, Lumley T, Furberg CD, Schellenbaum G, Pahor M, Alderman MH, et al. Health outcomes associated with various antihypertensive therapies used as first-line agents: a network meta-analysis. JAMA 2003;289:2534-2544. https://doi.org/10.1001/jama.289.19.2534
  33. Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet 2005;365:217-223. https://doi.org/10.1016/S0140-6736(05)70151-3
  34. Ministry of Health & Welfare, Korea Center For Disease Control & Prevention. Korea Health Statistics 2009: Korea National Health and Nutrition Examination Survey (KNHANES IV).
  35. Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB, et al. Heart disease and stroke statistics-2012 update: a report from the American Heart Association. Circulation 2012;125:e2-e220. https://doi.org/10.1161/CIR.0b013e31823ac046
  36. Stratton IM, Adler AI, Neil HA, Matthews DR, Manley SE, Cull CA, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 2000;321:405-412. https://doi.org/10.1136/bmj.321.7258.405
  37. Amarenco P, Labreuche J. Lipid management in the prevention of stroke: review and updated meta-analysis of statins for stroke prevention. Lancet Neurol 2009;8:453-463. https://doi.org/10.1016/S1474-4422(09)70058-4
  38. Jeong JH. Prevalence of and risk factors for atrial fibrillation in Korean adults older than 40 years. J Korean Med Sci 2005;20:26-30.
  39. Go AS, Hylek EM, Phillips KA, Chang Y, Henault LE, Selby JV, et al. Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study. JAMA 2001;285:2370-2375. https://doi.org/10.1001/jama.285.18.2370
  40. Jee SH, Suh I, Kim IS, Appel LJ. Smoking and atherosclerotic cardiovascular disease in men with low levels of serum cholesterol: the Korea Medical Insurance Corporation Study. JAMA 1999;282:2149-2155. https://doi.org/10.1001/jama.282.22.2149
  41. Jee SH, Park J, Jo I, Lee J, Yun S, Yun JE, et al. Smoking and atherosclerotic cardiovascular disease in women with lower levels of serum cholesterol. Atherosclerosis 2007;190:306-312. https://doi.org/10.1016/j.atherosclerosis.2006.03.023
  42. Park TH, Kim MK, Lee KB, Park JM, Lee SJ, Jung KH, et al. Population attributable risk of major risk factors for ischemic stroke in the Korean population. Korean J Stroke 2008;10:125-133.

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  79. Characteristics for Ischemic Stroke in 18–30 Years Old Patients, Multicenter Stroke Registry Study vol.40, pp.3, 2013, https://doi.org/10.12771/emj.2017.40.3.128
  80. Effect of emergency medical service use on time interval from symptom onset to hospital admission for definitive care among patients with intracerebral hemorrhage: a multicenter observational study vol.4, pp.3, 2013, https://doi.org/10.15441/ceem.16.147
  81. Stroke Epidemiology in South, East, and South-East Asia: A Review vol.19, pp.3, 2013, https://doi.org/10.5853/jos.2017.00234
  82. The Factors Associated With Health-Related Quality of Life in Stroke Survivors Age 40 and Older vol.41, pp.5, 2017, https://doi.org/10.5535/arm.2017.41.5.743
  83. Clinical Characteristics of Elderly Acute Ischemic Stroke Patients Calling Emergency Medical Services vol.21, pp.4, 2013, https://doi.org/10.4235/agmr.2017.21.4.164
  84. Prevalence of stroke, risk factors, disability and care needs in older adults in Singapore: results from the WiSE study vol.8, pp.3, 2013, https://doi.org/10.1136/bmjopen-2017-020285
  85. TOAST Subtypes of Ischemic Stroke and Its Risk Factors: A Hospital-Based Study at Cipto Mangunkusumo Hospital, Indonesia vol.2018, pp.None, 2013, https://doi.org/10.1155/2018/9589831
  86. Building Linked Big Data for Stroke in Korea: Linkage of Stroke Registry and National Health Insurance Claims Data vol.33, pp.53, 2013, https://doi.org/10.3346/jkms.2018.33.e343
  87. Ten-Year Mortality Trends for Adults with and without Diabetes Mellitus in South Korea, 2003 to 2013 vol.42, pp.5, 2018, https://doi.org/10.4093/dmj.2017.0088
  88. Revision Superficial Temporal Artery-Middle Cerebral Artery Bypass Surgery for Recurrent Acute Ischemic Stroke Due to Delayed Occlusion of the Bypass Graft vol.20, pp.2, 2013, https://doi.org/10.7461/jcen.2018.20.2.127
  89. Sleep Disturbances as a Risk Factor for Stroke vol.20, pp.1, 2013, https://doi.org/10.5853/jos.2017.02887
  90. Development and Validation of the Activities of Daily Living Short Form for Community-Dwelling Korean Stroke Survivors vol.41, pp.1, 2018, https://doi.org/10.1177/0163278717695863
  91. Chronic rhinosinusitis increases the risk of hemorrhagic and ischemic stroke: A longitudinal follow-up study using a national sample cohort vol.13, pp.3, 2013, https://doi.org/10.1371/journal.pone.0193886
  92. Neck dissection does not increases the risk of stroke in thyroid cancer: A national cohort study vol.13, pp.3, 2018, https://doi.org/10.1371/journal.pone.0195074
  93. Disability Measurement for Korean Community-Dwelling Adults With Stroke: Item-Level Psychometric Analysis of the Korean Longitudinal Study of Ageing vol.42, pp.2, 2013, https://doi.org/10.5535/arm.2018.42.2.336
  94. Stroke Among Young West Africans : Evidence From the SIREN (Stroke Investigative Research and Educational Network) Large Multisite Case–Control Study vol.49, pp.5, 2013, https://doi.org/10.1161/strokeaha.118.020783
  95. Nationwide Estimation of Eligibility for Endovascular Thrombectomy Based on the DAWN Trial vol.20, pp.2, 2018, https://doi.org/10.5853/jos.2018.00836
  96. IoT based wake-up stroke prediction - Recent trends and directions vol.402, pp.None, 2013, https://doi.org/10.1088/1757-899x/402/1/012045
  97. Endovascular Treatment in Acute Ischemic Stroke: A Nationwide Survey in Korea vol.13, pp.2, 2013, https://doi.org/10.5469/neuroint.2018.01053
  98. A retrospective cohort study on the outcomes of ischemic stroke patients with adjuvant Korean Medicine treatment vol.8, pp.None, 2018, https://doi.org/10.1038/s41598-018-19841-w
  99. Development of an Evidence-Based Clinical Practice Guideline of Korean Medicine for Stroke: A Study Protocol vol.39, pp.4, 2018, https://doi.org/10.13048/jkm.18032
  100. Kidney Dysfunction Impact on White Matter Hyperintensity Volume in Neurologically Healthy Adults vol.9, pp.None, 2013, https://doi.org/10.1038/s41598-019-45109-y
  101. Patient and hospital factors associated with 30-day unplanned readmission in patients with stroke vol.67, pp.1, 2013, https://doi.org/10.1136/jim-2018-000748
  102. Executive Summary of Stroke Statistics in Korea 2018: A Report from the Epidemiology Research Council of the Korean Stroke Society vol.21, pp.1, 2013, https://doi.org/10.5853/jos.2018.03125
  103. Prevalence of Stroke and Associated Risk Factors in Sleman District of Yogyakarta Special Region, Indonesia vol.2019, pp.None, 2013, https://doi.org/10.1155/2019/2642458
  104. Analysis of the Relationship between Adult Asthma and Stroke: A Longitudinal Follow-Up Study Using the Korean National Sample Cohort vol.2019, pp.None, 2013, https://doi.org/10.1155/2019/8919230
  105. Maintenance of body weight is an important determinant for the risk of ischemic stroke: A nationwide population-based cohort study vol.14, pp.1, 2013, https://doi.org/10.1371/journal.pone.0210153
  106. Current Status and Issues of Acute Stroke Management in Korea: Results of a Nationwide Acute Stroke Care Hospital Survey vol.37, pp.1, 2019, https://doi.org/10.17340/jkna.2019.1.6
  107. External Validation of Hematoma Expansion Scores in Spontaneous Intracerebral Hemorrhage in an Asian Patient Cohort vol.30, pp.2, 2013, https://doi.org/10.1007/s12028-018-0631-8
  108. Risk of ischaemic stroke in patients with migraine: a longitudinal follow-up study using a national sample cohort in South Korea vol.9, pp.4, 2019, https://doi.org/10.1136/bmjopen-2018-027701
  109. 2019 Update of the Korean Clinical Practice Guidelines of Stroke for Endovascular Recanalization Therapy in Patients with Acute Ischemic Stroke vol.21, pp.2, 2013, https://doi.org/10.5853/jos.2019.00024
  110. Heterogeneity in costs and prognosis for acute ischemic stroke treatment by comorbidities vol.266, pp.6, 2013, https://doi.org/10.1007/s00415-019-09278-0
  111. Factors influencing return to work after stroke: the Korean Stroke Cohort for Functioning and Rehabilitation (KOSCO) Study vol.9, pp.7, 2013, https://doi.org/10.1136/bmjopen-2018-028673
  112. Intracerebral hemorrhage: an update on diagnosis and treatment vol.19, pp.7, 2019, https://doi.org/10.1080/14737175.2019.1623671
  113. 2019 Update of the Korean Clinical Practice Guidelines of Stroke for Endovascular Recanalization Therapy in Patients with Acute Ischemic Stroke vol.14, pp.2, 2013, https://doi.org/10.5469/neuroint.2019.00164
  114. Sex disparity in acute ischemic stroke outcomes in Korea vol.12, pp.2, 2019, https://doi.org/10.18700/jnc.190108
  115. Emergency management of stroke in the era of mechanical thrombectomy vol.6, pp.4, 2013, https://doi.org/10.15441/ceem.18.065
  116. 뇌졸중의 약침 치료에 대한 메타분석의 통합적 고찰 vol.40, pp.6, 2019, https://doi.org/10.22246/jikm.2019.40.6.1081
  117. Aspirin for Primary Prevention of Cardiovascular Disease vol.8, pp.2, 2013, https://doi.org/10.12997/jla.2019.8.2.162
  118. 뇌졸중의 추나요법에 대한 체계적 문헌 고찰 vol.14, pp.2, 2013, https://doi.org/10.30581/jkcmm.2019.14.2.15
  119. Retrospective screening for Philadelphia-negative myeloproliferative neoplasms in patients with cerebral infarctions as revealed using the revised 2016 World Health Organization diagnostic criteria vol.54, pp.4, 2013, https://doi.org/10.5045/br.2019.54.4.284
  120. The prevalence of stroke according to indoor radon concentration in South Koreans : Nationwide cross section study vol.99, pp.4, 2013, https://doi.org/10.1097/md.0000000000018859
  121. Trends in the Incidence and Treatment of Cerebrovascular Diseases in Korea : Part II. Cerebral Infarction, Cerebral Arterial Stenosis, and Moyamoya Disease vol.63, pp.1, 2013, https://doi.org/10.3340/jkns.2018.0182
  122. Assessment of the Implementation of Critical Pathway in Stroke Patients: A 10-Year Follow-Up Study vol.2020, pp.None, 2020, https://doi.org/10.1155/2020/3265950
  123. A Retrospective Cohort Study of Risk of Gallbladder Disease in Acute Cerebral Infarction Patients vol.38, pp.1, 2013, https://doi.org/10.17340/jkna.2020.1.3
  124. Asian management of hypertension: Current status, home blood pressure, and specific concerns in Korea vol.22, pp.3, 2020, https://doi.org/10.1111/jch.13686
  125. Determinant of Quality of Life in Patients with Chronic Cerebral Infarct vol.13, pp.1, 2013, https://doi.org/10.12786/bn.2020.13.e4
  126. Hospital service utilization trajectories of individuals living with epilepsy in New South Wales, Australia, 2012–2016: A population-based study vol.105, pp.None, 2020, https://doi.org/10.1016/j.yebeh.2020.106941
  127. Distribution and current problems of acute endovascular therapy for large artery occlusion from a two-year national survey in Japan vol.15, pp.3, 2013, https://doi.org/10.1177/1747493019869706
  128. 2019 Update of the Korean Clinical Practice Guidelines of Stroke for Endovascular Recanalization Therapy in Patients with Acute Ischemic Stroke vol.38, pp.2, 2013, https://doi.org/10.17340/jkna.2020.2.1
  129. Five-Year Cumulative Cost Saving with Thrombolysis in Korea: 3-Month Disability-Based Estimation vol.22, pp.2, 2013, https://doi.org/10.5853/jos.2020.00556
  130. The Obesity Paradox in Spontaneous Intracerebral Hemorrhage: Results from a Retrospective Analysis of the Nationwide Inpatient Sample vol.32, pp.3, 2013, https://doi.org/10.1007/s12028-019-00796-3
  131. Echocardiographic parameters determining cardiovascular outcomes in patients after acute ischemic stroke vol.36, pp.8, 2013, https://doi.org/10.1007/s10554-020-01841-5
  132. Characteristics and management of stroke in Korea: 2014-2018 data from Korean Stroke Registry vol.15, pp.6, 2020, https://doi.org/10.1177/1747493019884517
  133. Historical diagnostic and therapeutic changes of ischemic stroke based on the highly cited articles vol.7, pp.2, 2013, https://doi.org/10.6087/kcse.211
  134. Mediating effect of waist:height ratio on the association between BMI and frailty: the Korean Frailty and Aging Cohort Study vol.124, pp.5, 2013, https://doi.org/10.1017/s0007114519002058
  135. An Age-Period-Cohort Analysis of Stroke Mortality Attributable to Low Physical Activity in China and Japan: Data from the GBD Study 1990–2016 vol.10, pp.None, 2020, https://doi.org/10.1038/s41598-020-63307-x
  136. Lifetime risks and health impacts of hemorrhagic and ischemic stroke in South Korea vol.10, pp.None, 2013, https://doi.org/10.1038/s41598-020-71439-3
  137. Patterns of enhancement in paretic shoulder kinematics after stroke with musical cueing vol.10, pp.1, 2013, https://doi.org/10.1038/s41598-020-75143-0
  138. The Association between Nonalcoholic Fatty Liver Disease and Stroke: Results from the Korean Genome and Epidemiology Study (KoGES) vol.17, pp.24, 2013, https://doi.org/10.3390/ijerph17249568
  139. Changes in Vessel Wall Enhancement Related to the Recent Neurological Symptoms in Patients with Moyamoya Disease vol.61, pp.9, 2021, https://doi.org/10.2176/nmc.oa.2021-0058
  140. Association between Periodontal Health and Stroke: Results from the 2013–2015 Korea National Health and Nutrition Examination Survey (KNHANES) vol.16, pp.1, 2021, https://doi.org/10.1016/j.jds.2020.05.006
  141. Evaluation of ECG Features for the Classification of Post-Stroke Survivors with a Diagnostic Approach vol.11, pp.1, 2013, https://doi.org/10.3390/app11010192
  142. Risk of Stroke in Systemic Necrotizing Vasculitis: A Nationwide Study Using the National Claims Database vol.12, pp.None, 2021, https://doi.org/10.3389/fimmu.2021.629902
  143. Hypertension and stroke in Asia: A comprehensive review from HOPE Asia vol.23, pp.3, 2013, https://doi.org/10.1111/jch.14099
  144. The Effect of Rehabilitation Motivation and Medical Staff Support on Self-care Activities in Stroke Patients with Rehabilitation Therapy vol.24, pp.1, 2013, https://doi.org/10.7587/kjrehn.2021.25
  145. A prospective, observational study of rivaroxaban for stroke prevention in atrial fibrillation: the XANAP Korea vol.36, pp.4, 2013, https://doi.org/10.3904/kjim.2020.217
  146. Association of Primary Hypertension and Risk of Cerebrovascular Diseases with Overweight and Physical Activity in Korean Women: A Longitudinal Study vol.9, pp.9, 2013, https://doi.org/10.3390/healthcare9091093
  147. Metabolomic analysis reveals potential biomarkers and serum metabolomic profiling in spontaneous intracerebral hemorrhage patients using UPLC/quadrupole time‐of‐flight MS vol.36, pp.1, 2013, https://doi.org/10.1002/bmc.5241