Journal of Korean Society of Occupational and Environmental Hygiene (한국산업보건학회지)

Korean Industrial Hygiene Association (한국산업보건학회)
권호 표지

Analysis of Trace Level and Correlation of Lead in the Plasma of Field Workers and General Public by ICP-MS

유도결합플라즈마 질량분석법에 의한 납 취급 근로자와 일반인의 혈장 중 납 분석 및 상관성 분석

  • Lee, Sung-Bae (Center for Chemical Safety & Health Research Center, Occupational Safety & Health Research Institute) ;
  • Yang, Jeong-Sun (Center for Chemical Safety & Health Research Center, Occupational Safety & Health Research Institute) ;
  • Choi, Sung-Bong (Center for Chemical Safety & Health Research Center, Occupational Safety & Health Research Institute) ;
  • Kim, Nam-Soo (Institute of Environmental and Occupational Medicine, Soonchunhyang University) ;
  • Lee, Byung-Kook (Institute of Environmental and Occupational Medicine, Soonchunhyang University) ;
  • Shin, Ho-Sang (Department of Environmental Education, Kongju National University)
  • 이성배 (산업안전보건연구원 화학물질센터) ;
  • 양정선 (산업안전보건연구원 화학물질센터) ;
  • 최성봉 (산업안전보건연구원 화학물질센터) ;
  • 김남수 (순천향대학교 환경산업의학연구소) ;
  • 이병국 (순천향대학교 환경산업의학연구소) ;
  • 신호상 (국립공주대학교 환경교육과)
  • Published : 2013.06.30
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Abstract

Objectives: This study attempted to develop a method to measure ultra-trace lead concentrations in plasma using Inductively Coupled Plasma Mass Spectrometry(ICP-MS) and to test whether plasma lead can be used as a biomarker for the biological monitoring of exposure to lead. Methods: Lead concentrations in 160 plasma samples of field workers and 42 plasma samples from the control group were measured by ICP-MS. Blood zinc protophorphyrin(ZPP) concentrations and urinary ${\delta}$-aminolevulinic acid${\delta}-ALA$) were measured for correlation analysis with plasma lead. Results: The mean lead level in the plasma of the workers exposed to lead at work were 786.1 ng/L. Plasma lead levels were not correlated with blood ZPP or urinary ${\delta}-ALA$ concentrations. Otherwise, plasma lead levels showed a good correlation coefficient of 0.400 with blood lead levels, and their correlation coefficient had a better value of 0.552 for the non-smoking and drinking group. In the general population group which was not exposed to lead in the workplace and was considered the control group, the mean concentration of plasma lead was 123.1 ng/L. The plasma lead levels for the general population group showed a good correlation coefficient of 0.520 with blood ZPP and urinary ${\delta}-ALA$ concentrations.

Keywords

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