Journal of Pharmacopuncture (대한약침학회지)

KOREAN PHARMACOPUNCTURE INSTITUTE (대한약침학회)
권호 표지
DOI QR코드

DOI QR Code

Anti-Allergic Effect of Ulmus davidiana Cortex on Contact Dermatitis Induced by Dinitrofluoro-Benzene in Mice

  • Lyu, Jeonghyeon (Division of Pharmacology, Pusan National University School of Korean Medicine) ;
  • Kim, Byung-Joo (Division of Longevity and Biofunctional Medicine, Pusan National University School of Korean Medicine) ;
  • Kim, Hyungwoo (Division of Pharmacology, Pusan National University School of Korean Medicine)
  • Received : 2013.03.19
  • Accepted : 2013.04.29
  • Published : 2013.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objective: The root bark of Ulmus davidiana var. Japonica (Ulmi Radicis cortex, URC) is a medicinal herb used for promoting diuresis and treating dampness. In Korea, URC has long been used as an efficacious therapy for inflammation, burns, frostbite and skin diseases such as eczema and psoriasis. Methods: In the present study, we used 1-fluoro-2,4-dinitrofluorobenzene (DNFB)-induced contact dermatitis (CD) mouse model to investigate the anti-allergic and the anti-inflammatory effects of URC on skin lesion, histopathological changes and specific antibody production. Results: URC treatment, 10 mg/mL, effectively inhibited skin lesions induced by repeated paintings with DNFB. In the histopathological observation, topical application of URC inhibited spongiosis. In addition, URC lowered the production levels of total immunoglobulin and IgG2a in serum. Conclusion: These data indicate that URC has an anti-inflammatory effect that produces an improvement of skin lesions in CD mice.

Keywords

References

  1. The textbook compilation committee of Korean herbology. Bonchohak. Seoul: Younglimsa; 2010. 735 p. Korean.
  2. Lee KH, Jeon EK, Yoo SY, Oh MJ. [Antioxidative activity of Ulmi cortex extract]. Korean J Postharvest Sci Technol. 2000;7(4):373-9. Korean.
  3. Song IK, Kim KS, Suh SJ, Kim MS, Kwon DY, Kim SL, et al. Anti-inflammatory effect of Ulmus davidiana Planch (Ulmaceae) on collagen-induced inflammation in rats. Environ Toxicol Pharmacol. 2007;23(1):102-10. https://doi.org/10.1016/j.etap.2006.07.013
  4. Choi SY, Lee S, Choi WH, Lee Y, Jo YO, Ha TY. Isolation and anti-inflammatory activity of Bakuchiol from Ulmus davidiana var. japonica. J Med Food. 2010;13(4):1019-23. https://doi.org/10.1089/jmf.2009.1207
  5. Lee TW, Kim SN, Jee UK, Hwang SJ. [Anti-wrinkle effect of pressure sensitive adhesive hydrogel patches containing Ulmi cortex extract]. J Kor Pharm Sci. 2004;34(3):193-9. Korean. https://doi.org/10.4333/KPS.2004.34.3.193
  6. Alase A, Wittmann M. Therapeutic strategies in allergic contact dermatitis. Recent Pat Inflamm Allergy Drug Discov. 2012;6(3):210-21. https://doi.org/10.2174/187221312802652794
  7. Dudeck A, Dudeck J, Scholten J, Petzold A, Surianarayanan S, Kohler A, et al. Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens. Immunity. 2011;34(6):973-84. https://doi.org/10.1016/j.immuni.2011.03.028
  8. Broide DH. Molecular and cellular mechanisms of allergic disease. J Allergy Clin Immunol. 2001;108(2 Suppl):S65-S71. https://doi.org/10.1067/mai.2001.116436
  9. Diepgen TL. Occupational skin diseases. J Dtsch Dermatol Ges. 2012;10(5):297-313.
  10. Saint-Mezard P, Rosieres A, Krasteva M, Berard F, Dubois B, Kaiserlian D, et al. Allergic contact dermatitis. Eur J Dermatol. 2004;14(5):284-95.
  11. Cohen D, Heidary N. Treatment of irritant and allergic contact dermatitis. Dermatol Ther. 2004;17(4):334-40. https://doi.org/10.1111/j.1396-0296.2004.04031.x
  12. Wen MC, Wei CH, Hu ZQ, Srivastava K, Ko J, Xi ST, et al. Efficacy and tolerability of anti-asthma herbal medicine intervention in adult patients with moderate-severe allergic asthma. J Allergy Clin Immunol. 2005;116(3):517-24. https://doi.org/10.1016/j.jaci.2005.05.029
  13. Kim H, Lee MR, Lee GS, An WG, Cho SI. Effect of Sophora flavescens Aiton extract on degranulation of mast cells and contact dermatitis induced by dinitrofluorobenzene in mice. J Ethnopharmacol. 2012;142(1):253-8. https://doi.org/10.1016/j.jep.2012.04.053
  14. Kim JK, Kim YH, Lee HH, Lim SS, Park KW. Effect of Scrophularia buergeriana extract on the degranulation of mast cells and ear swelling induced by dinitrofluorobenzene in mice. Inflammation. 2012;35(1):183-91. https://doi.org/10.1007/s10753-011-9304-x
  15. Jiang S, Nakano Y, Rahman MA, Yatsuzuka R, Kamei C. Effects of a Dictamnus dasycarpus T. extract on allergic models in mice. Biosci Biotechnol Biochem. 2008;72(3):660-5. https://doi.org/10.1271/bbb.70050
  16. Machado-Pinto J, McCalmont T, Golitz L. Eosinophilic and neutrophilic spongiosis: clues to the diagnosis of immunobullous diseases and other inflammatory disorders. Semin Cutan Med Surg. 1996;15(4):308-16. https://doi.org/10.1016/S1085-5629(96)80044-7