Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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The Effects of OnDam-tang-Kami-bang (ODK) in Antioxidant and Serotonin Metabolism Testing on P815 Cell

온담탕가미방(溫膽湯加味方)의 항산화와 Serotonin 대사 과정에 미치는 영향

  • Seol, Seon-Hui (Department of Neuropsychiatry, College of Korean Medicine, Daejeon University) ;
  • Lee, Sang Ryong (Department of Neuropsychiatry, College of Korean Medicine, Daejeon University) ;
  • Jung, In Chul (Department of Neuropsychiatry, College of Korean Medicine, Daejeon University)
  • 설선희 (대전대학교 한의과대학 신경정신과학교실) ;
  • 이상룡 (대전대학교 한의과대학 신경정신과학교실) ;
  • 정인철 (대전대학교 한의과대학 신경정신과학교실)
  • Received : 2013.05.23
  • Accepted : 2013.06.13
  • Published : 2013.06.30
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Abstract

Objectives : The purpose of this study is to examine the effects of antioxidant activities and serotonin activities of OnDam-tang-Kami-bang (ODK) on P815 Mast Cell. Methods : The effects of ODK on the activation of DPPH radical-scavenging and SOD in P815 mast cell were investigated. The effect of ODK on the content of serotonin in P815 mast cell was investigated. The effects of ODK on the activation of 5-HTT, TPH-1 mRNA in P815 mast cell were investigated. Results : It was found that the ODK increased SOD activities and DPPH radical-scavenging activities in the P815 mast cell. Also, the ODK decreased the intracellular concentration of serotonin in the P815 mast cell. Further, the ODK decreased 5-HTT and TPH-1 mRNA expression in the P815 mast cell. Conclusions : The results of this experiment reveal that ODK has significant antioxidative effects. However, ODK decreased the intracellular concentration of serotonin and mRNA expression of 5-HTT and TPH-1, which implies that ODK might not be effective for treating depression. Further research exploring the positive aspects of ODK is suggested such that ODK could adequately target symptoms that are to be treated.

Keywords

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