Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Protective Effects of SAPP, a Novel Herbal Complex, in Acute Hepatotoxic Mouse Model

  • Lee, Geum Seon (College of Pharmacy and Institute of Chronic Disease, Sahmyook University) ;
  • Lee, Ki Man (College of Pharmacy and Institute of Chronic Disease, Sahmyook University) ;
  • Kim, Seung Hyun (College of Pharmacy and Institute of Chronic Disease, Sahmyook University) ;
  • Jeong, Nam-Joo (Pharmaceutical Research Lab. PharmaKing Co. Ltd.) ;
  • Kim, Young-Jung (Department of Veterinary Medicine & Institute of Veterinary Science, Chungnam National University) ;
  • Jung, Ju-Young (Department of Veterinary Medicine & Institute of Veterinary Science, Chungnam National University) ;
  • Kang, Tae Jin (College of Pharmacy and Institute of Chronic Disease, Sahmyook University)
  • Received : 2013.03.27
  • Accepted : 2013.05.18
  • Published : 2013.06.30
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Abstract

The protective effect of SAPP, an extract from a novel herbal complex, on acute liver injury was investigated using mouse animal model in this study. The content of total phenol in SAPP was increased at dose dependent manner. Consistent with the content of total phenol, SAPP showed the significant anti-oxidative effects on 1, 1-diphenyl-2-picrylhydrazyl (DPPH) method. Acute liver injury was induced by D-galactosamine (D-GalN) in mouse. Treatment with SAPP significantly reduced the level of alanine transaminase (ALT) and aspartate transaminase (AST) in serum. Histological observation revealed that whereas D-GalN treated mouse showed vacuolization of hepatocytes, sinusoidal dilation and congestion, loss of cell boundaries and ballooning degeneration, loss of architecture and cell necrosis, treatment with SAPP improved D-GalN-induced liver injury. These results suggest that SAPP shows protective effects against D-GalN-induced hepatotoxicity in vivo acute mouse model.

Keywords

References

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