Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Adverse Effects of Preserved Vegetables on Squamous Cell Carcinoma of Esophagus and Precancer Lesions in a High Risk Area

  • Song, Qing-Kun (Cancer Institute/Hospital, the Chinese Academy of Medical Sciences and Peking Union Medical College) ;
  • Zhao, Lin (Xuanwu Hospital Capital Medical University) ;
  • Li, Jun (Yanting Cancer Hospital and Institute) ;
  • He, Yu-Ming (Yanting Cancer Hospital and Institute) ;
  • Jiang, Cui-Ping (Yanting Cancer Hospital and Institute) ;
  • Jiang, Hai-Dong (Yanting Cancer Hospital and Institute) ;
  • Qu, Chen-Xu (Cancer Institute/Hospital, the Chinese Academy of Medical Sciences and Peking Union Medical College)
  • Published : 2013.02.28
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Abstract

Introduction: Squamous cell carcinoma of esophagus (ESCC) is one of the most common cancers in China. Preserved vegetables are processed foods and consumed in high amounts in the high risk areas for ESCC. This study aimed to investigate the relationships of preserved vegetable consumption with ESCC and precancer lesions. Methods: Cases from Yanting cancer hospital with pathological diagnosis of primary cancer, along with controls and individuals diagnosed with precancer lesions by endoscopy with iodine staining were interviewed. Trained staff collected data on dietary habits 1 year before the interview. An unconditional logistic regression model was used to estimate odds ratios of preserved vegetable consumption for precancer lesions and cancer. Results: Adjusting for potential confounders, intake of preserved vegetables (OR=2.92, 95%CI 1.32~6.47) and longer intake period (OR=5.78, 95%CI 2.26~14.80) were associated with higher risk of ESCC. Compared with lowest intake frequency, the highest was associated with a 3.0-fold risk for precancer lesions and 3.59-fold risk for ESCC (both p<0.05). Conclusion: Consumption of preserved vegetables is a risk factor for esophageal lesions in high risk areas. The carcinogenicity of preserved vegetables needs investigation in further studies and the public health strategies for reducing the consumption might be initiated in high risk areas.

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References

  1. Arranz N, Haza AI, Garcia A, Rafter J, Morales P (2007). Protective effect of vitamin C towards N-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay. Toxicol In Vitro, 21, 1311-7. https://doi.org/10.1016/j.tiv.2007.03.015
  2. Broekmans WM, Klopping-Ketelaars IA, Schuurman CR, et al (2000). Fruits and vegetables increase plasma carotenoids and vitamins and decrease homocysteine in humans. J Nutr, 130, 1578-83.
  3. De Stefani E, Aune D, Boffetta P, et al (2009). Salted meat consumption and the risk of cancer: a multisite case-control study in Uruguay. Asian Pac J Cancer Prev, 10, 853-7.
  4. De Stefani E, Deneo-Pellegrini H, Mendilaharsu M, Ronco A (1999). Diet and risk of cancer of the upper aerodigestive tract--I. Foods. Oral Oncol, 35, 17-21. https://doi.org/10.1016/S1368-8375(98)00060-8
  5. De Stefani E, Deneo-Pellegrini H, Ronco AL, et al (2003). Food groups and risk of squamous cell carcinoma of the oesophagus: a case-control study in Uruguay. Br J Cancer, 89, 1209-14. https://doi.org/10.1038/sj.bjc.6601239
  6. Dong ZW, Peng Y (2011). Guidlines of Cancer Early Detection and Treatment (2011 edition). Beijing, People's Medical Publishing House
  7. Erkekoglu P Baydar T (2010). Evaluation of the protective effect of ascorbic acid on nitrite- and nitrosamine-induced cytotoxicity and genotoxicity in human hepatoma line. Toxicol Mech Methods, 20, 45-52. https://doi.org/10.3109/15376510903583711
  8. Fan Y, Yuan JM, Wang R, Gao YT, Yu MC (2008). Alcohol, tobacco, and diet in relation to esophageal cancer: the Shanghai Cohort Study. Nutr Cancer, 60, 354-63. https://doi.org/10.1080/01635580701883011
  9. Ferlay J, Shin H, Bray F, et al (2010). GLOBOCAN 2008 v1.2, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10 [Internet]. Lyon, France: International Agency for Research on Cancer. Available from: http://globocan.iarc.fr, accessed on 06/10/2011.
  10. Fong LY, Farber JL Magee PN (1998). Zinc replenishment reduces esophageal cell proliferation and N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumor incidence in zinc-deficient rats. Carcinogenesis, 19, 1591-6. https://doi.org/10.1093/carcin/19.9.1591
  11. Freedman ND, Park Y, Subar AF, et al (2007). Fruit and vegetable intake and esophageal cancer in a large prospective cohort study. Int J Cancer, 121, 2753-60. https://doi.org/10.1002/ijc.22993
  12. Garcia A, Morales P, Arranz N, et al (2009). Antiapoptotic effects of dietary antioxidants towards N-nitrosopiperidine and N-nitrosodibutylamine-induced apoptosis in HL-60 and HepG2 cells. J Appl Toxicol, 29, 403-13. https://doi.org/10.1002/jat.1426
  13. Guo W, Blot WJ, Li JY, et al (1994). A nested case-control study of oesophageal and stomach cancers in the Linxian nutrition intervention trial. Int J Epidemiol, 23, 444-50. https://doi.org/10.1093/ije/23.3.444
  14. He J, Zhao P Chen W (2011). Chinese Cancer Registry Annual Report 2011. Beijing, Military Medical Science Press.
  15. Islami F, Ren JS, Taylor PR, Kamangar F (2009). Pickled vegetables and the risk of oesophageal cancer: a meta-analysis. Br J Cancer, 101, 1641-7. https://doi.org/10.1038/sj.bjc.6605372
  16. Kamangar F, Chow WH, Abnet CC, Dawsey S (2009). Environmental causes of esophageal cancer. Gastroenterol Clin North Am, 38, 27-vii. https://doi.org/10.1016/j.gtc.2009.01.004
  17. Keszei AP, Schouten LJ, Goldbohm RA, van den Brandt PA (2012). Red and processed meat consumption and the risk of esophageal and gastric cancer subtypes in The Netherlands Cohort Study. Ann Oncol, 23, 2319-26. https://doi.org/10.1093/annonc/mdr615
  18. Lambert R Hainaut P (2007). Esophageal cancer: cases and causes (part I). Endoscopy, 39, 550-5. https://doi.org/10.1055/s-2007-966530
  19. Li K Yu P (2003). Food groups and risk of esophageal cancer in Chaoshan region of China: a high-risk area of esophageal cancer. Cancer Invest, 21, 237-40. https://doi.org/10.1081/CNV-120016420
  20. Lin K, Shen W, Shen Z, Cai S, Wu Y (2003). Estimation of the potential for nitrosation and its inhibition in subjects from high- and low-risk areas for esophageal cancer in southern China. Int J Cancer, 107, 891-5. https://doi.org/10.1002/ijc.11506
  21. Lin K, Shen W, Shen Z, Wu Y, Lu S (2002). Dietary exposure and urinary excretion of total N-nitroso compounds, nitrosamino acids and volatile nitrosamine in inhabitants of high- and low-risk areas for esophageal cancer in southern China. Int J Cancer, 102, 207-11. https://doi.org/10.1002/ijc.10698
  22. Lin K, Wu Y Shen W (2009). Interaction of total N-nitroso compounds in environment and in vivo on risk of esophageal cancer in the coastal area, China. Environ Int, 35, 376-81. https://doi.org/10.1016/j.envint.2008.09.005
  23. Lu SH, Ohshima H, Fu HM, et al (1986). Urinary excretion of N-nitrosamino acids and nitrate by inhabitants of high- and low-risk areas for esophageal cancer in Northern China: endogenous formation of nitrosoproline and its inhibition by vitamin C. Cancer Res, 46, 1485-91.
  24. Navarro Silvera SA, Mayne ST, Risch H, et al (2008). Food group intake and risk of subtypes of esophageal and gastric cancer. Int J Cancer, 123, 852-60. https://doi.org/10.1002/ijc.23544
  25. Ohsawa K, Nakagawa SY, Kimura M, et al (2003). Detection of in vivo genotoxicity of endogenously formed N-nitroso compounds and suppression by ascorbic acid, teas and fruit juices. Mutat Res, 539, 65-76. https://doi.org/10.1016/S1383-5718(03)00156-6
  26. Pandeya N, Williams G, Green AC, et al (2009). Alcohol consumption and the risks of adenocarcinoma and squamous cell carcinoma of the esophagus. Gastroenterology, 136, 1215-24. https://doi.org/10.1053/j.gastro.2008.12.052
  27. Pandeya N, Williams GM, Sadhegi S, et al (2008). Associations of duration, intensity, and quantity of smoking with adenocarcinoma and squamous cell carcinoma of the esophagus. Am J Epidemiol, 168, 105-14. https://doi.org/10.1093/aje/kwn091
  28. Parkin DM, Bray F, Ferlay J, Pisani P (2005). Global cancer statistics, 2002. CA Cancer J Clin, 55, 74-108. https://doi.org/10.3322/canjclin.55.2.74
  29. Pedersen CB, Kyle J, Jenkinson AM, et al (2000). Effects of blueberry and cranberry juice consumption on the plasma antioxidant capacity of healthy female volunteers. Eur J Clin Nutr, 54, 405-8. https://doi.org/10.1038/sj.ejcn.1600972
  30. Ribeiro U, Jr., Posner MC, Safatle-Ribeiro AV, Reynolds JC (1996). Risk factors for squamous cell carcinoma of the oesophagus. Br J Surg, 83, 1174-85. https://doi.org/10.1002/bjs.1800830905
  31. Siddiqi MA, Tricker AR, Kumar R, Fazili Z, Preussmann R (1991). Dietary sources of N-nitrosamines in a high-risk area for oesophageal cancer--Kashmir, India. IARC Sci Publ, 1991, 210-3.
  32. Song Q, Wang X, Yu IT, et al (2012). Processed food consumption and risk of esophageal squamous cell carcinoma: A case-control study in a high risk area. Cancer Sci, 103, 2007-11. https://doi.org/10.1111/j.1349-7006.2012.02387.x
  33. Song QK, Li J, Jiang HD, et al (2012). Esophageal Cancer Mortality during 2004-2009 in Yanting County, China. Asian Pac J Cancer Prev, 13, 5003-6. https://doi.org/10.7314/APJCP.2012.13.10.5003
  34. Straif K, Weiland SK, Bungers M, et al (2000). Exposure to high concentrations of nitrosamines and cancer mortality among a cohort of rubber workers. Occup Environ Med, 57, 180-7. https://doi.org/10.1136/oem.57.3.180
  35. Sullivan PA, Eisen EA, Woskie SR, et al (1998). Mortality studies of metalworking fluid exposure in the automobile industry: VI. A case-control study of esophageal cancer. Am J Ind Med, 34, 36-48. https://doi.org/10.1002/(SICI)1097-0274(199807)34:1<36::AID-AJIM6>3.0.CO;2-O
  36. Sun X, Chen W, Chen Z, et al (2010). Population-based case-control study on risk factors for esophageal cancer in five high-risk areas in China. Asian Pac J Cancer Prev, 11, 1631-6.
  37. Tran GD, Sun XD, Abnet CC, et al (2005). Prospective study of risk factors for esophageal and gastric cancers in the Linxian general population trial cohort in China. Int J Cancer, 113, 456-63. https://doi.org/10.1002/ijc.20616
  38. Wang GQ, Abnet CC, Shen Q, et al (2005). Histological precursors of oesophageal squamous cell carcinoma: results from a 13 year prospective follow up study in a high risk population. Gut, 54, 187-92. https://doi.org/10.1136/gut.2004.046631
  39. Wang YP, Han XY, Su W, et al (1992). Esophageal cancer in Shanxi Province, People's Republic of China: a case-control study in high and moderate risk areas. Cancer Causes Control, 3, 107-13. https://doi.org/10.1007/BF00051650
  40. Yamaji T, Inoue M, Sasazuki S, et al (2008). Fruit and vegetable consumption and squamous cell carcinoma of the esophagus in Japan: the JPHC study. Int J Cancer, 123, 1935-40. https://doi.org/10.1002/ijc.23744
  41. Yu Y, Taylor PR, Li JY, et al (1993). Retrospective cohort study of risk-factors for esophageal cancer in Linxian, People's Republic of China. Cancer Causes Control, 4, 195-202.
  42. Zhang SW, Chen WQ, Kong LZ, et al (2006). An analysis of cancer incidence and mortality from 30 cancer registries in China, 1998-2002. Zhong Guo Zhong Liu, 15, 430-448.

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