Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Estimating the Five-Year Survival of Cervical Cancer Patients Treated in Hospital Universiti Sains Malaysia

  • Razak, Nuradhiathy Abd (Institute of Graduate Studies, University of Malaya) ;
  • Khattak, M.N. (Alberta Health Services, Health Protection Communicable Disease Control) ;
  • Zubairi, Yong Zulina (Centre for Foundation Studies in Science, University of Malaya) ;
  • Naing, Nyi Nyi (Unit of Biostatistics and Research Methodology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia) ;
  • Zaki, Nik Mohamed (Department of Obstetrics and Gynaecology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia)
  • Published : 2013.02.28
Download PDF
⟨ Previous Next ⟩

Abstract

Objective: The objective of this study was to determine the five-year survival among patients with cervical cancer treated in Hospital Universiti Sains Malaysia. Methods: One hundred and twenty cervical cancer patients diagnosed between $1^{st}$ July 1995 and $30^{th}$ June 2007 were identified. Data were obtained from medical records. The survival probability was determined using the Kaplan-Meier method and the log-rank test was applied to compare the survival distribution between groups. Results: The overall five-year survival was 39.7% [95%CI (Confidence Interval): 30.7, 51.3] with a median survival time of 40.8 (95%CI: 34.0, 62.0) months. The log-rank test showed that there were survival differences between the groups for the following variables: stage at diagnosis (p=0.005); and primary treatment (p=0.0242). Patients who were diagnosed at the latest stage (III-IV) were found to have the lowest survival, 18.4% (95%CI: 6.75, 50.1), compared to stage I and II where the five-year survival was 54.7% (95%CI: 38.7, 77.2) and 40.8% (95%CI: 27.7, 60.3), respectively. The five-year survival was higher in patients who received surgery [52.6% (95%CI: 37.5, 73.6)] as a primary treatment compared to the non-surgical group [33.3% (95%CI: 22.9, 48.4)]. Conclusion: The five-year survival of cervical cancer patients in this study was low. The survival of those diagnosed at an advanced stage was low compared to early stages. In addition, those who underwent surgery had higher survival than those who had no surgery for primary treatment.

Keywords

References

  1. American Cancer Society (2011). Global Cancer Facts and Figures 2nd Edition. Atlanta: American Cancer Society.
  2. Aziz MF (2009). Gynecological cancer in Indonesia. J Gynecol Oncol, 20, 8-10. https://doi.org/10.3802/jgo.2009.20.1.8
  3. Brun JL, Stoven-Camou D, Trouette R et al (2003). Survival and prognosis of women with invasive cervical cancer according to age. Gynecol Oncol, 91, 395-401. https://doi.org/10.1016/S0090-8258(03)00501-8
  4. Chemay NK, Naing NN, Rahman MNG, Bachok N (2008). Prognostic factors of prostate cancer patients at Hospital Universiti Sains Malaysia. Int Med J, 15, 225-31.
  5. Chen RJ, Lin YH, Chen CA et al (1999). Influence of Histologic Type and Age on Survival Rates for Invasive Cervical Carcinoma in Taiwan. Gynecolc Oncol, 73, 184-90. https://doi.org/10.1006/gyno.1999.5364
  6. Chung HH, Jang MJ, Jung KW et al (2006). Cervical cancer incidence and survival in Korea: 1993-2002. Int J Gynecol Cancer, 16, 1833-8. https://doi.org/10.1111/j.1525-1438.2006.00708.x
  7. Ferlay J, Shin H, Bray F et al (2010). Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer, 127, 2893-917. https://doi.org/10.1002/ijc.25516
  8. Flores-Luna L, Salazar-Martinez E, Escudero-De los Rios P, et al (2001). Prognostic factors related to cervical cancer survival in Mexican women. Int J Gynecol Obstet, 75 , 33-42. https://doi.org/10.1016/S0020-7292(01)00471-4
  9. Forouzanfar MH, Foreman KJ, Delossantos AM et al (2011). Breast and cervical cancer in 187 countries between 1980 and 2010: a systematic analysis. Lancet, 378, 1461-84. https://doi.org/10.1016/S0140-6736(11)61351-2
  10. Galic V, Herzog TJ, Lewin SN et al (2012). Prognostic significance of adenocarcinoma histology in women with cervical cancer. Gynecol Oncol, 125, 287-91. https://doi.org/10.1016/j.ygyno.2012.01.012
  11. Garipagaoglu M, Yalvac S, Kose MF, et al (1999). Treatment results and prognostic factors in inoperable carcinoma of the cervix treated with external plus high dose brachytherapy. Cancer Letter, 136, 17-26. https://doi.org/10.1016/S0304-3835(98)00293-6
  12. Ghazali AK, Musa KI, Naing NN, Mahmood Z (2010). Prognostic factors in patients with colorectal cancer at Hospital Universiti Sains Malaysia. Asian J Surg, 33, 127-33. https://doi.org/10.1016/S1015-9584(10)60022-X
  13. Kumari KG, Sudhakar G, Ramesh M, Kalpana VL, Paddaiah G (2010). Prognostic factors in cervical cancer: a hospital-based retrospective study from Visakhapatnam City, Andhra Pradesh. J Life Sci, 2, 99-105.
  14. Kyrgiou M, Shafi MI (2010). Invasive cancer of the cervix. Obstet Gynaecol Reprod Med, 20, 147-54. https://doi.org/10.1016/j.ogrm.2010.02.003
  15. Laudico A, Mapua C (2011). Cancer survival in Manila, Philippines, 1994-1995. In: 'Cancer survival in Africa, Asia, the Caribbean and Central America', Eds. Sankaranarayanan R and Swaminathan R. IARC Scientific Publications No. 162, IARC Press, Lyon.
  16. Lee ET, Wang JW (2003). Statistical Methods for Survival Data Analysis, New Jersey: John Wiley & Son, Inc.
  17. Pomros P, Sriamporn S, Tangvoraphonkchai V, Kamsa-Ard S, Poomphakwaen K (2007). Factors affecting survival of cervical cancer patients treated at the Radiation Unit of Srinagarind Hospital, Khon Kaen University, Thailand. Asian Pac J Cancer Prev, 8, 297-300.
  18. Razak AA, Saddki N, Naing NN, Abdullah N (2010). Oral cancer survival among Malay Patients in Hospital Universiti Sains Malaysia, Kelantan. Asian Pac J Cancer Prev, 11, 187-91.
  19. Sankaranarayanan R, Swaminathan R, Jayant K, Brenner H (2011). An overview of cancer survival in Africa, Asia, the Caribbean and Central America: the case for investment in cancer health services. In: 'Cancer survival in Africa, Asia, the Caribbean and Central America', Eds. Sankaranarayanan R and Swaminathan R. IARC Scientific Publications No. 162, IARC Press, Lyon.
  20. Shingleton HM, Bell MC, Fremgen A et al (1995). Is there really a difference in survival of women with squamous cell carcinoma, adenocarcinoma, and adenosquamous cell carcinoma of the cervix? Cancer, 76, 1948-55. https://doi.org/10.1002/1097-0142(19951115)76:10+<1948::AID-CNCR2820761311>3.0.CO;2-T
  21. Sirait AM, Soetiarto F, Oemiatil R (2003). Survival Rate of cervical cancer patients in Dharmais Cancer Hospital, Jakarta Bul Penel Kesehatan, 31, 13-24.
  22. Sumitsawan Y, Srisukho S, Sastraruji A, et al (2011). Cancer survival in Chiang Mai, Thailand, 1993-1997. In: 'Cancer survival in Africa, Asia, the Caribbean and Central America', Eds. Sankaranarayanan R and Swaminathan R. IARC Scientific Publications No. 162, IARC Press, Lyon.
  23. Wahidah T, Khattak MN, Wan-Arfah N, Naing NN (2012). Prognostic Factors of Osteosarcoma Patients in Hospital Universiti Sains Malaysia. Int Med J, 19, 150-3.
  24. Xiang YB, Jin F, Gao YT (2011). Cancer survival in Shanghai, China, 1992-1995. In: 'Cancer survival in Africa, Asia, the Caribbean and Central America', Eds. Sankaranarayanan R and Swaminathan R. IARC Scientific Publications No. 162, IARC Press, Lyon.
  25. Yeh SA, Leung SW, Wang CJ, Chen HC (1999). Postoperative radiotherapy in early stage carcinoma of the uterine cervix: treatment results and prognostic factors. Gynecol Oncol, 72, 10-5 https://doi.org/10.1006/gyno.1998.5217
  26. Zainal Ariffin O, Nor Saleha IT (2011). National Cancer Registry Report 2007. Ministry of Health, Malaysia.

Cited by

  1. Cost-Effectiveness of Korea's National Cervical Cancer Screening Program vol.14, pp.7, 2013, https://doi.org/10.7314/APJCP.2013.14.7.4329
  2. Gynaecological Cancer Mortality in Serbia, 1991-2010: A Joinpoint Regression Analysis vol.16, pp.1, 2015, https://doi.org/10.7314/APJCP.2015.16.1.157
  3. Antibody Immobilization Method for Immonosensor Application vol.16, pp.12, 2015, https://doi.org/10.7314/APJCP.2015.16.12.5115
  4. Survival Rates of Cervical Cancer Patients in Malaysia vol.16, pp.7, 2015, https://doi.org/10.7314/APJCP.2015.16.7.3067
  5. Association of Educational Levels with Survival in Indian Patients with Cancer of the Uterine Cervix vol.16, pp.8, 2015, https://doi.org/10.7314/APJCP.2015.16.8.3121
  6. Comparative Assessment of a Self-sampling Device and Gynecologist Sampling for Cytology and HPV DNA Detection in a Rural and Low Resource Setting: Malaysian Experience vol.16, pp.18, 2016, https://doi.org/10.7314/APJCP.2015.16.18.8495