Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Correlation between Magnifying Narrow-band Imaging Endoscopy Results and Organoid Differentiation Indicated by Cancer Cell Differentiation and its Distribution in Depressed-Type Early Gastric Carcinoma

  • Tatematsu, Hidezumi (Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine) ;
  • Miyahara, Ryoji (Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine) ;
  • Shimoyama, Yoshie (Department of Pathology and Clinical Laboratories, Nagoya University Graduate School of Medicine) ;
  • Funasaka, Kohei (Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine) ;
  • Ohno, Eizaburou (Department of Endoscopy, Nagoya University Hospital) ;
  • Nakamura, Masanao (Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine) ;
  • Kawashima, Hiroki (Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine) ;
  • Itoh, Akihiro (Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine) ;
  • Ohmiya, Naoki (Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine) ;
  • Hirooka, Yoshiki (Department of Endoscopy, Nagoya University Hospital) ;
  • Watanabe, Osamu (Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine) ;
  • Maeda, Osamu (Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine) ;
  • Ando, Takafumi (Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine) ;
  • Goto, Hidemi (Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine)
  • Published : 2013.05.30
Download PDF
⟨ Previous Next ⟩

Abstract

Background: A close association between patterns identified by magnifying narrow-band imaging (M-NBI) and histological type has been described. M-NBI patterns were also recently reported to be related to the mucin phenotype; however, detials remain unclear. Materials and Methods: We investigated the cellular differentiation of gastric cancer lesions, along with their mucosal distribution observed by M-NBI. Ninety-seven depressed-type early gastric cancer lesions (74 differentiated and 23 undifferentiated adenocarcinomas) were visualized by M-NBI. Findings were divided into 4 patterns based on abnormal microvascular architecture: a chain loop pattern (CLP), a fine network pattern (FNP), a corkscrew pattern (CSP), and an unclassified pattern. Mucin phenotypes were judged as gastric (G-type), intestinal (I-type), mixed gastric and intestinal (M-type), and null (N-type) based on 4 markers (MAC5AC, MUC6, MUC2, and CD10). The relationship of each pattern of microvascular architecture with organoid differentiation indicated by cancer cell differentiation and its distribution in each histological type of early gastric cancer was investigated. Results: All CLP and FNP lesions were differentiated. The cancer cell distribution showed organoid differentiation in 84.2% (16/19) and 61.1% (22/36) of the two types of lesions, respectively, and there was a significant difference from the unclassified pattern with organoid differentiation (p<0.001). Almost all (94.7%; 18/19) CSP lesions were undifferentiated, and organoid differentiation was observed in 72.2% (13/18). There was a significant difference from the unclassified pattern with organoid differentiation (p<0.05). Conclusions: Cellular differentiation and distribution are associated with microvascular architecture observed by M-NBI.

Keywords

References

  1. Akamatsu T, Katsuyama T (1990). Histochemical demonstration of mucins in the intramucosal laminated structure of human gastric signet ring cell carcinoma and its relation to submucosal invasion. Histochem J, 22, 416-25. https://doi.org/10.1007/BF01003461
  2. Fujimori Y, Akamatsu T, Ota H, Katsuyama T (1995). Proliferative markers in gastric carcinoma and organoid differentiation. Hum Pathol, 26, 725-34. https://doi.org/10.1016/0046-8177(95)90219-8
  3. Japanese Gastric Cancer Association (1998). Japanese classification of gastric carcinoma: 2nd English edition. Gastric Cancer, 1, 10-24. https://doi.org/10.1007/PL00011681
  4. Kobayashi M, Takeuchi M, Ajioka Y, et al (2011). Mucin phenotype and narrow-band imaging with magnifying endoscopy for differentiated-type mucosal gastric cancer. J Gastroenterol, 46, 1064-70. https://doi.org/10.1007/s00535-011-0418-6
  5. Lauwers GY, Franceschi S, Tatematsu M, et al (2010). In 'Gastric carcinoma'. Eds Bosman BT, Carneiro F, Hruban RH, et al. WHO Classification of Tumours of the Digestive System. 4th ed. Lyon pp 48-58.
  6. Nakayoshi T, Tajiri H, Matsuda K, et al (2004). Magnifying endoscopy combined with narrow band imaging system for early gastric cancer: correlation of vascular pattern with histopathology (including video). Endoscopy, 36, 1080-4. https://doi.org/10.1055/s-2004-825961
  7. Saito A, Shimoda T, Nakanishi Y, et al (2001). Histologic heterogeneity and mucin phenotypic expression in early gastric cancer. Pathol Int, 51, 165-71. https://doi.org/10.1046/j.1440-1827.2001.01179.x
  8. Shiroshita H, Watanabe H, Ajioka Y, et al (2004). Re-evaluation of mucin phenotypes of gastric minute well-differentiated type adenocarcinomas using a series of HGM, MUC5AC, MUC6, M-GGMC, MUC2 and CD10 stains. Pathol Int, 54, 311-21. https://doi.org/10.1111/j.1440-1827.2004.01625.x
  9. Takizawa K, Shimoda T, Nakanishi Y, et al (2006). Expanded indication for endoscopic resection from the pathological viewpoint- The possibility of sm invasion by undifferentiatedtype early gastric cancer. Stomach and Intestine, 41, 9-17.
  10. Yagi K, Aruga Y, Nakamura A, Sekine A, Umezu H (2005). The study of dynamic chemical magnifying endoscopy in gastric neoplasia. Gastrointest Endosc, 62, 963-9. https://doi.org/10.1016/j.gie.2005.08.050
  11. Yagi K, Nakamura A, Sekine A, Umezu H (2008). Magnifying endoscopy with narrow band imaging for early differentiated gastric adenocarcinoma. Dig Endosc, 20, 115-22. https://doi.org/10.1111/j.1443-1661.2008.00788.x
  12. Yamachika T, Inada K, Fujimitsu Y, et al (1997). Intestinalization of gastric signet ring cell carcinomas with progression. Virchows Arch, 431, 103-10. https://doi.org/10.1007/s004280050075
  13. Yao K, Oishi T, Matsui T, et al (2002). Novel magnified endoscopic findings of microvascular architecture in intramucosal gastric cancer. Gastrointest Endosc, 56, 279-84. https://doi.org/10.1016/S0016-5107(02)70194-6
  14. Yokoyama A, Inoue H, Minami H, et al (2010). Novel narrowband imaging magnifying endoscopic classification for early gastric cancer. Dig Liver Dis, 42, 704-8. https://doi.org/10.1016/j.dld.2010.03.013

Cited by

  1. Risk of Lymph Node Metastases from Early Gastric Cancer in Relation to Depth of Invasion: Experience in a Single Institution vol.15, pp.13, 2014, https://doi.org/10.7314/APJCP.2014.15.13.5371
  2. Long-Term Outcomes after D2 Gastrectomy for Early Gastric Cancer: Survival Analysis of a Single-Center Experience in China vol.15, pp.17, 2014, https://doi.org/10.7314/APJCP.2014.15.17.7219
  3. Histological verification of the usefulness of magnifying endoscopy with narrow-band imaging for horizontal margin diagnosis of differentiated-type early gastric cancers pp.1436-3305, 2017, https://doi.org/10.1007/s10120-017-0734-5