Diabetes and Metabolism Journal

Korean Diabetes Association (대한당뇨병학회)
권호 표지
DOI QR코드

DOI QR Code

Chemokine Systems Link Obesity to Insulin Resistance

  • Ota, Tsuguhito (Department of Cell Metabolism and Nutrition, Brain/Liver Interface Medicine Research Center, Kanazawa University School of Medicine)
  • Published : 2013.06.17
⟨ Previous Next ⟩

Abstract

Obesity is a state of chronic low-grade systemic inflammation. This chronic inflammation is deeply involved in insulin resistance, which is the underlying condition of type 2 diabetes and metabolic syndrome. A significant advance in our understanding of obesity-associated inflammation and insulin resistance has been recognition of the critical role of adipose tissue macrophages (ATMs). Chemokines are small proteins that direct the trafficking of immune cells to sites of inflammation. In addition, chemokines activate the production and secretion of inflammatory cytokines through specific G protein-coupled receptors. ATM accumulation through C-C motif chemokine receptor 2 and its ligand monocyte chemoattractant protein-1 is considered pivotal in the development of insulin resistance. However, chemokine systems appear to exhibit a high degree of functional redundancy. Currently, more than 50 chemokines and 18 chemokine receptors exhibiting various physiological and pathological properties have been discovered. Therefore, additional, unidentified chemokine/chemokine receptor pathways that may play significant roles in ATM recruitment and insulin sensitivity remain to be fully identified. This review focuses on some of the latest findings on chemokine systems linking obesity to inflammation and subsequent development of insulin resistance.

Keywords

Cited by

  1. Deficiency in adipocyte chemokine receptor CXCR4 exacerbates obesity and compromises thermoregulatory responses of brown adipose tissue in a mouse model of diet-induced obesity vol.28, pp.10, 2014, https://doi.org/10.1096/fj.14-249797
  2. Ubiquitin ligase Cbl-b and obesity-induced insulin resistance [Review] vol.61, pp.6, 2013, https://doi.org/10.1507/endocrj.ej14-0048
  3. Systems genetics of obesity in an F2 pig model by genome-wide association, genetic network, and pathway analyses vol.5, pp.None, 2014, https://doi.org/10.3389/fgene.2014.00214
  4. Hypertrophic Obesity and Subcutaneous Adipose Tissue Dysfunction vol.6, pp.2, 2013, https://doi.org/10.18585/inabj.v6i2.33
  5. Active ingredients from natural botanicals in the treatment of obesity vol.15, pp.12, 2013, https://doi.org/10.1111/obr.12228
  6. Anti-adipogenic effect of mulberry leaf ethanol extract in 3T3-L1 adipocytes vol.8, pp.6, 2013, https://doi.org/10.4162/nrp.2014.8.6.613
  7. Macrophage Migration Inhibitory Factor Promoter Polymorphisms (−794 CATT 5–8 and −173 G>C): Relationship with mRNA Expression and Soluble MIF Levels in Young Obese vol.2015, pp.None, 2013, https://doi.org/10.1155/2015/461208
  8. Association of serum angiopoietin-like protein 2 with carotid intima-media thickness in subjects with type 2 diabetes vol.14, pp.None, 2015, https://doi.org/10.1186/s12933-015-0198-z
  9. Analysis of the correlation between serum resistin and the variability of erythropoietin responsiveness in patients with chronic kidney disease vol.10, pp.5, 2013, https://doi.org/10.3892/etm.2015.2772
  10. Niche-Dependent Regulations of Metabolic Balance in High-Fat Diet–Induced Diabetic Mice by Mesenchymal Stromal Cells vol.64, pp.3, 2013, https://doi.org/10.2337/db14-1042
  11. Asthma and metabolic syndrome: Current knowledge and future perspectives vol.3, pp.3, 2013, https://doi.org/10.12998/wjcc.v3.i3.285
  12. Moderate exercise training inhibits lipid metabolism and macrophage infiltration in high fat diet-induced obese mice vol.24, pp.2, 2013, https://doi.org/10.15857/ksep.2015.24.2.161
  13. Simvastatin Does Not Reduce Chemokine Production in Obesity Without Comorbidities vol.38, pp.3, 2013, https://doi.org/10.1007/s10753-014-0100-2
  14. Milk‐derived peptide Val‐Pro‐Pro (VPP) inhibits obesity‐induced adipose inflammation via an angiotensin‐converting enzyme (ACE) dependent cascade vol.59, pp.12, 2015, https://doi.org/10.1002/mnfr.201500324
  15. TM-25659-Induced Activation of FGF21 Level Decreases Insulin Resistance and Inflammation in Skeletal Muscle via GCN2 Pathways vol.38, pp.12, 2013, https://doi.org/10.14348/molcells.2015.0100
  16. Les adipokines : état des lieux et nouveautés vol.11, pp.3, 2013, https://doi.org/10.1007/s11690-016-0537-6
  17. Silencing CCR2 in Macrophages Alleviates Adipose Tissue Inflammation and the Associated Metabolic Syndrome in Dietary Obese Mice vol.5, pp.None, 2013, https://doi.org/10.1038/mtna.2015.51
  18. Distinguishing features of body mass index and psoriasis in men and women in Japan: A hospital‐based case–control study vol.43, pp.12, 2013, https://doi.org/10.1111/1346-8138.13439
  19. CCL2 Serum Levels and Adiposity Are Associated with the Polymorphic Phenotypes -2518A on CCL2 and 64ILE on CCR2 in a Mexican Population with Insulin Resistance vol.2016, pp.None, 2016, https://doi.org/10.1155/2016/5675739
  20. The Dietary Isoflavone Daidzein Reduces Expression of Pro-Inflammatory Genes through PPARα/γ and JNK Pathways in Adipocyte and Macrophage Co-Cultures vol.11, pp.2, 2013, https://doi.org/10.1371/journal.pone.0149676
  21. Obesity-associated cancer: an immunological perspective vol.75, pp.2, 2013, https://doi.org/10.1017/s0029665115004176
  22. Immune and Inflammatory Signaling Pathways in Exercise and Obesity vol.10, pp.4, 2013, https://doi.org/10.1177/1559827614552986
  23. CCL2 level is elevated with metabolic syndrome and CXCL10 level is correlated with visceral fat area in obese children vol.63, pp.9, 2013, https://doi.org/10.1507/endocrj.ej15-0731
  24. Mechanisms of inflammatory responses and development of insulin resistance: how are they interlinked? vol.23, pp.1, 2013, https://doi.org/10.1186/s12929-016-0303-y
  25. Change in Serum Bilirubin Level as a Predictor of Incident Metabolic Syndrome vol.11, pp.12, 2013, https://doi.org/10.1371/journal.pone.0168253
  26. From chronic overnutrition to metaflammation and insulin resistance: adipose tissue and liver contributions vol.591, pp.19, 2013, https://doi.org/10.1002/1873-3468.12742
  27. Polygala tenuifolia extract inhibits lipid accumulation in 3T3-L1 adipocytes and high-fat diet–induced obese mouse model and affects hepatic transcriptome and gut microbiota profiles vol.61, pp.None, 2013, https://doi.org/10.1080/16546628.2017.1379861
  28. The association between metabolic health, obesity phenotype and the risk of breast cancer vol.140, pp.12, 2013, https://doi.org/10.1002/ijc.30684
  29. Effects of Karela ( Bitter Melon; Momordica charantia ) on genes of lipids and carbohydrates metabolism in experimental hypercholesterolemia: biochemical, molecular and histopathological study vol.17, pp.None, 2013, https://doi.org/10.1186/s12906-017-1833-x
  30. TREM-1 associated macrophage polarization plays a significant role in inducing insulin resistance in obese population vol.15, pp.None, 2017, https://doi.org/10.1186/s12967-017-1187-7
  31. The Role of Heparin Cofactor II in the Regulation of Insulin Sensitivity and Maintenance of Glucose Homeostasis in Humans and Mice vol.24, pp.12, 2013, https://doi.org/10.5551/jat.37739
  32. Rosiglitazone Elicits an Adiponectin-Mediated Insulin-Sensitizing Action at the Adipose Tissue-Liver Axis in Otsuka Long-Evans Tokushima Fatty Rats vol.2018, pp.None, 2013, https://doi.org/10.1155/2018/4627842
  33. Resveratrol reduces the inflammatory response in adipose tissue and improves adipose insulin signaling in high-fat diet-fed mice vol.6, pp.None, 2018, https://doi.org/10.7717/peerj.5173
  34. Inflammatory Cytokine Profiles in Visceral and Subcutaneous Adipose Tissues of Obese Patients Undergoing Bariatric Surgery Reveal Lack of Correlation With Obesity or Diabetes vol.30, pp.None, 2013, https://doi.org/10.1016/j.ebiom.2018.03.004
  35. Myeloid-specific deletion of thrombospondin 1 protects against inflammation and insulin resistance in long-term diet-induced obese male mice vol.315, pp.6, 2013, https://doi.org/10.1152/ajpendo.00273.2018
  36. Inonotus sanghuang Polyphenols Attenuate Inflammatory Response Via Modulating the Crosstalk Between Macrophages and Adipocytes vol.10, pp.None, 2019, https://doi.org/10.3389/fimmu.2019.00286
  37. The chemokine system and its role in obesity vol.234, pp.4, 2019, https://doi.org/10.1002/jcp.27293
  38. Contribution of Oxidative Stress and Impaired Biogenesis of Pancreatic β-Cells to Type 2 Diabetes vol.31, pp.10, 2013, https://doi.org/10.1089/ars.2018.7656
  39. Interleukin-22 Induces the Infiltration of Visceral Fat Tissue by a Discrete Subset of Duffy Antigen Receptor for Chemokine-Positive M2-Like Macrophages in Response to a High Fat Diet vol.8, pp.12, 2013, https://doi.org/10.3390/cells8121587
  40. Anti-Obesity Effects of Petasites japonicus (Meowi) Ethanol Extract on RAW 264.7 Macrophages and 3T3-L1 Adipocytes and Its Characterization of Polyphenolic Compounds vol.12, pp.5, 2013, https://doi.org/10.3390/nu12051261
  41. Obesity-related hypoxia via miR-128 decreases insulin-receptor expression in human and mouse adipose tissue promoting systemic insulin resistance vol.59, pp.None, 2013, https://doi.org/10.1016/j.ebiom.2020.102912
  42. Transcriptome Analysis of Testis from HFD-Induced Obese Rats ( Rattus norvigicus ) Indicated Predisposition for Male Infertility vol.21, pp.18, 2013, https://doi.org/10.3390/ijms21186493
  43. β-Neoendorphin Enhances Wound Healing by Promoting Cell Migration in Keratinocyte vol.25, pp.20, 2013, https://doi.org/10.3390/molecules25204640
  44. Polymorphisms in miRNA binding sites involved in metabolic diseases in mice and humans vol.10, pp.None, 2020, https://doi.org/10.1038/s41598-020-64326-4
  45. CX3CL1-CX3CR1 Signaling Deficiency Exacerbates Obesity-induced Inflammation and Insulin Resistance in Male Mice vol.162, pp.6, 2013, https://doi.org/10.1210/endocr/bqab064
  46. Di(2-ethylhexyl)phthalate exposure exacerbates metabolic disorders in diet-induced obese mice vol.156, pp.None, 2021, https://doi.org/10.1016/j.fct.2021.112439
  47. The Chemokine Systems at the Crossroads of Inflammation and Energy Metabolism in the Development of Obesity vol.22, pp.24, 2021, https://doi.org/10.3390/ijms222413528