Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Low Prevalence of HPV in Male Sexual Partners of HR-HPV Infected Females and Low Concordance of Viral Types in Couples in Eastern Guangdong

  • Huang, Yue (Medical Laboratory Center, Chaozhou Central Hospital) ;
  • Lin, Min (Medical Laboratory Center, Chaozhou Central Hospital) ;
  • Luo, Zhao-Yun (Medical Laboratory Center, Chaozhou Central Hospital) ;
  • Li, Wen-Yu (Medical Laboratory Center, Chaozhou Central Hospital) ;
  • Zhan, Xiao-Fen (Medical Laboratory Center, Chaozhou Central Hospital) ;
  • Yang, Li-Ye (Medical Laboratory Center, Chaozhou Central Hospital)
  • Published : 2013.03.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objective: To investigate the prevalence of genital high-risk human papillomavirus (HR-HPV) in male sexual partners of HR-HPV infected women and the concordance of viral types in couples in China, and comprehend the role of men play in HPV transmission to women. Methods/Materials: 94 asymptomatic women and their husbands from rural Chaozhou participated in epidemiologic screening for HPV infection. Cervical cells from females were collected for high risk HPV screening by real time-PCR, and they were positive for at least 1 of 13 HR-HPV subtypes, then these samples were genotyped. Approximately one mouth later, penile epithelial cells from 94 asymptomatic husbands were collected for HPV genotyping. At the same time, a cross-sectional study was conducted in 366 male patients from sexually transmitted disease (STD) outpatient clinic in China for the prevalence of genital HR-HPV infection in men having frequent sex behavior. Penial epithelial cells were collected for HPV 6/11 and HPV 16/18 detection by fluorescent real-time quantified PCR. Results: Among 94 couples, the prevalence of genital HR-HPV infection in men whose wife was positive for cervical HR-HPV was 5.32% (5/94). Only 2.63% (2/76) had the same high risk viral type presented by their wife. HPV 16 proved to be the most prevalent viral type in men and in couples. Of 366 male patients from STD outpatient clinic, the prevalence of HPV 16/18 infection in men with or without HPV 6/11 was 6.85% and 8.16%, respectively. The incidence of HPV 16/18 was higher in men aged more than 35 years than the young men (18-35 years). Conclusion: The prevalence of genital HR-HPV infection in male sexual partners of HPV-positive women in China was lower than that expected, and the concordance of high risk viral type between couples was extremely low. These data suggested that infected men consitute an important viral reservoir, contributing to transmission of HR-HPV to women and maintenance of infection, but HR-HPV infection may be less likely to persist in men than in women.

Keywords

References

  1. Giuliano AR, Lazcano-Ponce E, Villa LL,, et al (2008). The human papillomavirus infection in men study: Human papillomavirus prevalence and type distribution among men residing in Brazil, Mexico, and the United States. Cancer Epidemiol Biomarkers Prev, 8, 2038.
  2. Bleeker MCG, Hogewoning CJA, Berkhof J (2005). Concordance of specific human papillomavirus types in sex partners is more prevalent than would be expected by chance and is associated with increased viral loads. Clin Infect Dis, 1, 612-20.
  3. Burchell AN, Tellier PP, Hanley J, Coutlee F, Franco EL (2010). Human papilloma -virus infections among couples in new sexual relationships. Epidemiology, 21, 31-7. https://doi.org/10.1097/EDE.0b013e3181c1e70b
  4. Castellsague X, Bosch FX, Munoz N, et al (2002). Male circumcision, penile human papillomavirus (HPV) infection, and cervical cancer in female partners. N Engl J Med, 346, 1105-12. https://doi.org/10.1056/NEJMoa011688
  5. Chen Q, Luo ZY, Lin M, et al (2012). Prevalence and genotype distribution of human papillomavirus infections in women attending hospitals in Chaozhou of Guangdong province. Asian Pac J Cancer Prev, 13, 1519-24. https://doi.org/10.7314/APJCP.2012.13.4.1519
  6. Chen Q, Xie LX, Qing ZR, et al (2012). Epidemiologic characterization of human papillomavirus infection in rural Chaozhou, eastern Guangdong Province of China. PLoS One, 7, e32149. https://doi.org/10.1371/journal.pone.0032149
  7. Cheung JL, Cheung TH, Ng CW, et al (2009). Analysis of human papillomavirus type 18 load and integration status from low-grade cervical lesion to invasive cervical cancer. J Clin Microbiol, 47, 287-93. https://doi.org/10.1128/JCM.01531-08
  8. de Lima Rocha MG, Faria FL, Gonçalves L, et al (2012). Prevalence of DNA-HPV in male sexual partners of HPVinfected women and concordance of viral types in infected couples. Plos One, 10, 11-7.
  9. De Lima Rocha MG, Faria FL, Souza MCM, Vago AR, Fernandes APSM (2008). Detection of human papillomavirus infection in penile samples through liquid-based cytology and polymerase chain reaction. Cancer, 114, 489-93. https://doi.org/10.1002/cncr.23947
  10. Della TG, Donghi R, Pasquini G, et al (1992). Human papillomavirus genomes in male urethral cells. Am J Pathol, 141, 1181-6.
  11. Dunne EF, Nielson CM, Stone KM, Markowitz LE, Giuliano AR (2006). Prevalence of HPV infection among men: A systematic review of the literature. J Infect Dis, 194, 1044-57. https://doi.org/10.1086/507432
  12. Flores R, Abalos AT, Nielson CM, et al (2008). Reliability of sample collection and laboratory testing for HPV detection in men. J Virol Methods, 149, 136-43. https://doi.org/10.1016/j.jviromet.2007.12.010
  13. Foresta C, Ferlin A, Bertoldo A, et al (2011). Human papilloma virus in the sperm cryobank: An emerging problem? Int J Androl, 34, 242-6. https://doi.org/10.1111/j.1365-2605.2010.01075.x
  14. Forslund O, Hansson BG, Rymark P, Bjerre B (1993). Human papillomavirus DNA in urine samples compared with that in simultaneously collected urethra and cervix samples. J Clin Microbiol, 31, 1975-9.
  15. Gillison ML, Broutian T, Pickard RK, et al (2012). Prevalence of oral HPV infection in the United States, 2009-2010. JAMA, 307, 693-703. https://doi.org/10.1001/jama.2012.101
  16. Giraldo PC, Eleuterio J Jr, Cavalcante DI, et al (2008). The role of high-risk HPV-DNA testing in the male sexual partners of women with HPV-induced lesions. Eur J Obstet Gynecol Reprod Biol, 137, 88-91. https://doi.org/10.1016/j.ejogrb.2006.12.026
  17. Giraldo PC, Goncalves AK, Eleuterio-Junior J (2006). Secretory immunoglobulin A: A protective factor in the genital mucosa. Braz J Infect Dis, 10, 232-4.
  18. Giuliano AR (2007). Human papillomavirus vaccination in males. Gynecol Oncol, 107, 24-6. https://doi.org/10.1016/j.ygyno.2007.07.075
  19. Giuliano AR, Anic G, Nyitray AG (2010). Epidemiology and pathology of HPV disease in males. Gynecol Oncol, 117, 15-9. https://doi.org/10.1016/j.ygyno.2010.01.026
  20. Giuliano AR, Lee JH, Fulp W, et al (2011). Incidence and clearance of genital human papillomavirus infection in men (HIM): A cohort study. Lancet, 377 , 932-40. https://doi.org/10.1016/S0140-6736(10)62342-2
  21. Giuliano AR, Lu B, Nielson CM, et al (2008). Age-specific prevalence, incidence, and duration of human papillomavirus infections in a cohort of 290 US men. J Infect Dis, 198, 827-35. https://doi.org/10.1086/591095
  22. Kreider JW, Howett MK, Wolfe SA, et al (1985). Morphologic transformation in vivo of human uterine cervix with papillomavirus from condylomata acuminata. Nature, 317, 639. https://doi.org/10.1038/317639a0
  23. Lin M, Yang LY, Li LJ, et al (2008). Genital human papillomavirus screening by gene chip in Chinese women of Guangdong province. Aust N Z J Obstet Gynaecol, 48, 189-94. https://doi.org/10.1111/j.1479-828X.2008.00844.x
  24. Louvanto K, Syrjanen KJ, Rintala MA, Grenman SE, Syrjanen SM (2010). Genotype -specific clearance of genital human papillomavirus (HPV) infections among mothers in the Finnish family HPV study. J Clin Microbiol, 48, 2665-71. https://doi.org/10.1128/JCM.00783-10
  25. Lu B, Viscidi RP, Lee JH, et al (2011). Human papillomavirus (HPV) 6, 11, 16, and 18 seroprevalence is associated with sexual practice and age: Results from the multinational HPV Infection in Men Study (HIM Study). Cancer Epidemiol Biomarkers Prev, 20, 990-1002. https://doi.org/10.1158/1055-9965.EPI-10-1160
  26. Molano M, Van den Brule A, Plummer M, et al (2003). Determinants of clearance of human papillomavirus infections in Colombian women with normal cytology: A population-based, 5-year follow-up study. Am J Epidemiol, 158, 486-94. https://doi.org/10.1093/aje/kwg171
  27. Nicolau SM, Camargo CG, Stavale JN (2005). Human papillomavirus DNA detection in male sexual partners of women with genital human papillomavirus infection. Urology, 65, 251-5. https://doi.org/10.1016/j.urology.2004.09.031
  28. Parada R, Morales R, Giuliano AR, et al (2010). Prevalence, concordance and determinants of human papillomavirus infection among heterosexual partners in a rural region in central Mexico. BMC Infect Dis, 10, 223. https://doi.org/10.1186/1471-2334-10-223
  29. Partridge JM, Koutsky LA (2006). Genital human papillomavirus infection in men. Lancet, 6, 21-31. https://doi.org/10.1016/S1473-3099(05)70323-6
  30. Reiter PL, Pendergraft WF, Brewer NT (2010). Meta-analysis of human papilloma -virus infection concordance. Cancer Epidemiol Biomarkers Prev, 11, 2916-31.
  31. Seaman WT, Andrews E, Couch M, et al (2010). Detection and quantitation of HPV in genital and oral tissues and fluids by real time PCR. Virol J, 7, 194. https://doi.org/10.1186/1743-422X-7-194
  32. Shin HR, Franceschi S, Vaccarella S, et al (2004). Prevalence and determinants of genital infection with papillomavirus, in female and male university students in Busan, South Korea. J Infect Dis, 190, 468-76. https://doi.org/10.1086/421279
  33. Silins I, Kallings I, Dillner J (2000). Correlates of the spread of human papilloma -virus infection. Cancer Epidemiol Biomarkers Prev, 9, 953-9.
  34. Simon P, Roumeguere T, Christophe Noel J (2010). Human papillomavirus infection in couples with female low-grade intraepithelial cervical lesion. Eur J Obstet Gynecol Reprod Biol, 153, 8-11. https://doi.org/10.1016/j.ejogrb.2010.05.024
  35. Svare EI, Kjaer SK, Worm AM, et al (2002). Risk factors for genital HPV DNA in men resemble those found in women: A study of male attendees at a Danish STD clinic. Sex Transm Infect, 78, 215-8. https://doi.org/10.1136/sti.78.3.215
  36. Takahashi S, Shimizu T, Takeyama K (2003). Detection of human papllomavirus DNA on the external genitalia of healthy men and male patients with urethritis. Sex Transm Dis, 30, 629-33. https://doi.org/10.1097/01.OLQ.0000085184.68124.B3
  37. Takahashi S, Takeyama K, Miyamoto S, et al (2005). Incidence of sexually transmitted infections in asymptomatic healthy young Japanese men. J Infect Chemother, 21, 76-82.
  38. Van Doornum GJ, Prins M, Juffermans LH, et al (1994). Regional distribution and incidence of human papillomavirus infections among heterosexual men and women with multiple sexual partners: A prospective study. Genitourin Med, 70, 240-6.
  39. Weaver BA, Feng Q, Holmes KK, et al (2004). Evaluation of genital sites and sampling techniques for detection of human papillomavirus DNA in men. J Infect Dis, 189, 677-85. https://doi.org/10.1086/381395

Cited by

  1. Genotype Distribution of Human Papillomavirus in Women with Abnormal Cervical Cytology in an Esophageal Carcinoma High Incidence Area of China vol.15, pp.12, 2014, https://doi.org/10.7314/APJCP.2014.15.12.4945
  2. Prevalence of human papillomaviruses in the healthy oral mucosa of women with high-grade squamous intra-epithelial lesion and of their partners as compared to healthy controls vol.44, pp.9, 2015, https://doi.org/10.1111/jop.12302
  3. The Prevalence and Genotype of Human Papillomavirus from Patients with Genital Warts in Eastern Guangdong Province vol.16, pp.14, 2015, https://doi.org/10.7314/APJCP.2015.16.14.5675
  4. Natural history of human papillomavirus infection in non-vaccinated young males: low clearance probability in high-risk genotypes vol.35, pp.3, 2016, https://doi.org/10.1007/s10096-015-2562-z
  5. Prevalence and genotype distribution of human papillomavirus among females in the suburb of Shanghai, China vol.90, pp.1, 2017, https://doi.org/10.1002/jmv.24899