Journal of the Korean Society of Radiology (한국방사선학회논문지)

The Korean Society of Radiology (한국방사선학회)
권호 표지
DOI QR코드

DOI QR Code

Dose Evaluation of Childhood Leukemia in Total Body Irradiation

소아백혈병의 전신방사선조사시 선량평가

  • Lee, Dongyeon (Department of Radiological Science, College of Health Sciences, Catholic University of Pusan) ;
  • Ko, Seongjin (Department of Radiological Science, College of Health Sciences, Catholic University of Pusan) ;
  • Kang, Sesik (Department of Radiological Science, College of Health Sciences, Catholic University of Pusan) ;
  • Kim, Changsoo (Department of Radiological Science, College of Health Sciences, Catholic University of Pusan) ;
  • Kim, Donghyun (Department of Radiological Science, College of Health Sciences, Catholic University of Pusan) ;
  • Kim, Junghoon (Department of Radiological Science, College of Health Sciences, Catholic University of Pusan)
  • 이동연 (부산가톨릭대학교 보건과학대학 방사선학과) ;
  • 고성진 (부산가톨릭대학교 보건과학대학 방사선학과) ;
  • 강세식 (부산가톨릭대학교 보건과학대학 방사선학과) ;
  • 김창수 (부산가톨릭대학교 보건과학대학 방사선학과) ;
  • 김동현 (부산가톨릭대학교 보건과학대학 방사선학과) ;
  • 김정훈 (부산가톨릭대학교 보건과학대학 방사선학과)
  • Received : 2013.06.20
  • Accepted : 2013.08.25
  • Published : 2013.08.31
Download PDF
⟨ Previous Next ⟩

Abstract

Total body irradiation in the treatment of childhood leukemia, which is one of the pre-treatment with stem cell transplantation is being used, the current organization using compensators are treated. However, under the terms of the compensator organization long-term impact on the human body, it is difficult to assess directly. In this study, we use the mathematical simulation of radiation exposures body energy and the distance to the crew and the patient (source surface distance, SSD), and patients with tissue compensators change of the distance along the body of the organ doses were evaluated. As a result, the surface dose of energy 4 MV, SSD 280 cm, tissue compensators and the patient when the distance 30 cm 5.84 G / min showed the highest levels. In addition, patients with tissue compensators and the distance apart when 30 cm TBI represents the ideal dose distribution was found.

전신방사선조사는 소아백혈병의 치료 방법 중 하나인 조혈모세포이식의 전처치로 이용되고 있으며, 현재 조직보상체를 사용하여 치료를 시행하고 있다. 그러나 조직보상체의 조건에 따라 인체 내부 장기에 미치는 영향을 직접 평가하는 것은 어려움이 있다. 이에 본 연구는 수학적 모의피폭체를 사용하여 방사선의 에너지와 선원과 환자와의 거리(source surface distance, SSD), 조직보상체와 환자와의 거리 변화에 따라 인체 장기의 선량을 평가하였다. 그 결과, 표면선량은 에너지 4 MV, SSD 280 cm, 조직보상체와 환자와의 거리 30 cm일 때 5.84 G/min 으로 가장 높은 수치를 나타내었다. 또한 조직보상체와 환자와의 거리가 30 cm 이하였을 때 TBI에서 가장 이상적인 선량분포를 나타냄을 알 수 있었다.

Keywords

References

  1. Kim SH, Yu IY, "Identification of symtoms by treatment phases in children with leukemia", The graduate school of nursing Yonsei University, 2009.
  2. Kim SJ, Han DG, Baek HJ et al. "Comparison of Total Body Irradiation (TBI) or Non-TBI as conditioning Regimen for Stem Cell Transplanation (SCT) in Pediatric Leukemia patient", Korean Jounal of Pediatrics, Vol. 53, No. 4, pp.538-547, 2010. https://doi.org/10.3345/kjp.2010.53.4.538
  3. "The Physics Of Radiation Therapy-Fourth Edition", Lippincott Williams & Wilkins, Philadelphia, US, 2003.
  4. "ICRP Publication 89, Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values", Ann. ICRP 32 (3-4), Elsevier Publishing Company, 2002
  5. "ICRU Report NO. 49, Stopping Power and Ranges for Protons and Alpha Particles", Oxford Vniv. Pr. UK, 1993
  6. Choi JH, Kim JS et al., "Analysis of Surface Dose Refer to Distance between Beam Spoiler and Patient in Total Body Irradiation" Korean Society Radiotherapeutic Technology, Vol. 19, No. 1, pp51-54, 2007
  7. Ahn SJ, Kang WS, Park SJ et al. "The Dosimetric Data of 10 MV Linear Accelerator Photon Beam for Total Body Irradiation", J.Korean. Soc. Ther. Radiol, Vol. 12, No. 2, pp.225-232, 1994
  8. "National Cancer Registration Statistics 2010", Central Cancer Registry in Korea, National Cancer Center and Ministry of Health and Welfare, Republic of Korea, 2012
  9. Choi SY, "Results of autologous peripheral blood stem cell transplantation in childhood acute myelocytic leukemia patients with continuous complete remission during consolidation chemotherapy" Department of Medicine The Graduate School, Yonsei University, 2006
  10. Park SJ, Jung WG, An SJ et al. "Utilization of Tissue Compensator for Uniform Dose Distribution in Total Body Irradiation" J. Korean Soc. Ther. Radiol. Oncol. Vol. 12 No. 2 pp. 233-242, 1994.
  11. Min WS, Cho SG, Chung IJ, "Autologous bome marrow transplanatation for acute myeloid leukemia in first remission, Purging with hyperthermia and ether lipid in vitron" Korean Cancer Association, pp. 670-677, 1996.
  12. Jung DH, Lee JO, Kang JG et al. "Measurement and Monte Carlo Simulation of 6 MV X-rays for Small Radiation Field", J. Korean SOC Ther. Radiol. Oncol. Vol. 16 No. 2, pp. 195-202, 1998.
  13. Jung GH, Su TS, Jo BC, "The Effect of The Statistical Uncertainties in Monte Carlo Phton Dose Calculation for the Radiation Therapy" J. Korea Asso. Radiat. Prot. Vol. 29, No. 2 pp. 105-115, 2004.

Cited by

  1. The Apoptosis according to the Processing Irradiation and The Tumor Necrosis Factor vol.10, pp.3, 2016, https://doi.org/10.7742/jksr.2016.10.3.195
  2. TRAIL and Effect of Irradiation on Apoptosis of Cancer Cells vol.10, pp.6, 2016, https://doi.org/10.7742/jksr.2016.10.6.387
  3. The Study of Dosimetry according to the Thickness of Beam Spoiler on Total Body Irradiation vol.8, pp.5, 2014, https://doi.org/10.7742/jksr.2014.8.5.265
  4. Radiation Dose Calculation using MIRD TYPE PHANTOM in the Surrounding Organs during Brachytherapy of Breast Cancer vol.10, pp.4, 2016, https://doi.org/10.7742/jksr.2016.10.4.271