Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Sleep Inducing Effect of Gastrodia elata Fermented with Lactic Acid Bacteria

유산균 발효 천마의 수면유도 효과

  • 이경호 ((주)종근당중앙연구소) ;
  • 이기형 (공주대학교 산업과학대학) ;
  • 김병수 (공주대학교 산업과학대학) ;
  • 최영호 (공주대학교 산업과학대학) ;
  • 김충환 (공주대학교 산업과학대학)
  • Received : 2013.07.23
  • Accepted : 2013.08.19
  • Published : 2013.09.30
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Abstract

Ethanol extract of Gastrodia elata fermented with Lactobacillus brevis was highly effective on the duration of pentobarbital hypnosis in mice. Pretreatment of mice with ethanol extract of the fermented Gastrodia elata (200 mg/kg, p.o.) prolonged markedly the duration of pentobarbital sleeping time and reduced the sleep latency. The mechanism of the extract of the fermented Gastrodia elata was investigated to inhibit the binding of $^3H$-Flumazenil, a selective benzodiazepine receptor antagonist, to benzodiazepine receptor of mice cortices. $IC_{50}$ value from displacement of $^3H$-Flumazenil binding was 62 ${\mu}g/mL$ at the treatment of the fermented Gastrodia elata. Therefore, these finding, such as increase of sleeping time and reduction of sleep latency, was examined by elevated concentration of GABA and parishin C, which were increased by Lactobacillus brevis.

Keywords

References

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