Preventive Nutrition and Food Science

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Alleviating Effects of Baechu Kimchi Added Ecklonia cava on Postprandial Hyperglycemia in Diabetic Mice

  • Lee, Hyun-Ah (Department of Food Science and Nutrition, Pusan National University) ;
  • Song, Yeong-Ok (Department of Food Science and Nutrition, Pusan National University) ;
  • Jang, Mi-Soon (Food and Safety Research Center, National Fisheries Research & Development Institute) ;
  • Han, Ji-Sook (Department of Food Science and Nutrition, Pusan National University)
  • Received : 2013.05.24
  • Accepted : 2013.08.28
  • Published : 2013.09.30
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Abstract

In this study, we investigated the inhibitory effects of Baechu kimchi added Ecklonia cava on the activities of ${\alpha}$-glucosidase and ${\alpha}$-amylase and its alleviating effect on the postprandial hyperglycemia in STZ-induced diabetic mice. Baechu kimchi added Ecklonia cava (BKE, 15%) was fermented at $5^{\circ}C$ for 28 days. Optimum ripened BKE was used in this study as it showedthe strongest inhibitory activities on ${\alpha}$-glucosidase and ${\alpha}$-amylaseby fermentation time among the BKEs in our previous study. The BKE was extracted with 80% methanol and the extract solution was concentrated, and then used in this study. The BKE extract showed higher inhibitory activities than Baechu kimchi extract against ${\alpha}$-glucosidase and ${\alpha}$-amylase. The $IC_{50}$ values of the BKE extract against ${\alpha}$-glucosidase and ${\alpha}$-amylase were 0.58 and 0.35 mg/mL, respectively; BKE exhibited a lower ${\alpha}$-glucosidase inhibitory activity but a higher ${\alpha}$-amylase inhibitory activity than those of acarbose. The BKE extract alleviated postprandial hyperglycemia caused by starch loading in normal and streptozotocin- induced diabetic mice. Furthermore, the BKE extract significantly lowered the incremental area under the curve in both normal and diabetic mice (P<0.05). These results indicated that the BKE extract may delay carbohydrate digestion and thus glucose absorption.

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References

  1. Tappy L, Le KA. 2010. Metabolic effects of fructose and the worldwide increase in obesity. Physiol Rev 90: 23-46. https://doi.org/10.1152/physrev.00019.2009
  2. Muoio DM, Newgard CB. 2006. Obesity-related derangement in metabolic regulation. Annu Rev Biochem 75: 367-401. https://doi.org/10.1146/annurev.biochem.75.103004.142512
  3. Akkarachiyasit S, Charoenlertkul P, Yibchok-Anun S, Adisakwattana S. 2010. Inhibitory activities of cyaniding and its glycosides and synergistic effect with acarbose against intestinal ${\alpha}$-glucosidase and pancreatic ${\alpha}$-amylase. Int J Mol Sci 11: 3387-3396. https://doi.org/10.3390/ijms11093387
  4. Baron AD. 1998. Postprandial hyperglycemic and alpha-glucosidase inhibitors. Diabetes Res Clin Pract 40: 51-55. https://doi.org/10.1016/S0168-8227(98)00043-6
  5. Eurich DT, McAlicter FA, Blackburn DF, Majumdar SR, Tsuyuki RT, Varney J, Johnson JA. 2007. Benefits and harms of antidiabetic agents in patients with diabetes and heart failure: systematic review. BMJ 335: 497. https://doi.org/10.1136/bmj.39314.620174.80
  6. Saito N, Sakai H, Suzuki S, Sekihara H, Yajima Y. 1998. Effect of an alpha-glucosidase inhibitor (voglibose), in combination with sulphonylureas, on glycaemic control in type 2 diabetes patients. J Int Med Res 26: 219-232. https://doi.org/10.1177/030006059802600501
  7. Stand E, Baumgartl HJ, Fuchtenbusch M, Stemplinger J. 1999. Effect of acarbose on addition insulin therapy in type 2 diabetes patients with late failure of sulphonylurea therapy. Diabetes Obes Metab 1: 215-220. https://doi.org/10.1046/j.1463-1326.1999.00021.x
  8. Li Y, Lee SH, Le QT, Kim MM, Kim SK. 2008. Anti-allergic effects of phlorotannins on histamine release via binding inhibition between IgE and Fc${\epsilon}$RI. J Agric Food Chem 56: 12073-12080. https://doi.org/10.1021/jf802732n
  9. Ahn MJ, Yoon KD, Min SY, Lee JS, Kim JH, Kim TG, Kim SH, Kim NG, Hun H, Kim J. 2004. Inhibition of HIV-1 reverse transcriptase and protease by phlorotannins from the brown alga, Ecklonia cava. Biol Pharm Bull 27: 544-547. https://doi.org/10.1248/bpb.27.544
  10. Lee SH, Li Y, Karadeniz F, Kim MM, Kim SK. 2009. ${\alpha}$-Glucosidase and ${\alpha}$-amylase inhibitory activities of phloroglucinal derivatives from edible marine brown alga, Ecklonia cava. J Sci Food Agric 89: 1552-1558. https://doi.org/10.1002/jsfa.3623
  11. Park JM, Shin JH, Gu JG, Yoon SJ, Song JC, Jeon WM, Suh HJ, Chang UJ, Yang CY, Kim JM. 2011. Effect of antioxidant activity in kimchi during a short-term and over-ripening fermentation period. J Biosci Bioeng 112: 356-359. https://doi.org/10.1016/j.jbiosc.2011.06.003
  12. Kim MJ, Kwon MJ, Song YO, Lee EK, Youn HJ, Song YS. 1997. The effects of kimchi on hematological and immunological parameters in vivo and in vitro. J Korean Soc Food Sci Nutr 26: 1208-1214.
  13. Nan HM, Park JW, Song YJ, Yun HY, Park JS, Hyun T, Youn SJ, Kim YD, Kang JW, Kim H. 2005. Kimchi and soybean pastes are risk factors of gastric cancer. World J Gastroenterol 11: 3175-3181. https://doi.org/10.3748/wjg.v11.i21.3175
  14. Islam MS, Choi H. 2009. Antidiabetic effect of Korean traditional Baechu (Chinese cabbage) kimchi in a type 2 diabetes model of rats. J Med Food 12: 292-297. https://doi.org/10.1089/jmf.2008.0181
  15. Watanabe J, Kawabata J, Kurihara H, Niki R. 1997. Isolation and identification of alpha-glucosidase inhibitors from tochu-cha (Eucommia ulmoides). Biosci Biotechnol Biochem 61: 177-178. https://doi.org/10.1271/bbb.61.177
  16. Kim JS. 2004. Effect of Rhemanniae radix on the hyperglycemic mice induced with streptozotocin. J Korean Soc Food Sci Nutr 33: 1133-1138. https://doi.org/10.3746/jkfn.2004.33.7.1133
  17. Gerich JE. 2003. Clinical significance, pathogenesis, and management of postprandial hyperglycemia. Arch Intern Med 163: 1306-1316. https://doi.org/10.1001/archinte.163.11.1306
  18. Abrahamson MJ. 2004. Optimal glycemic control in type 2 diabetes mellitus: fasting and postprandial glucose in context. Arch Intern Med 164: 486-491. https://doi.org/10.1001/archinte.164.5.486
  19. Haller H. 1998. The clinical importance of postprandial glucose. Diabetes Res Clin Pract 40: 43-49. https://doi.org/10.1016/S0168-8227(98)00042-4
  20. Bhandari MR, Anurakkun NJ, Hong G, Kawabata J. 2008. ${\alpha}$-Glucosidase and ${\alpha}$-amylase inhibitory activities of Nepalese medicinal herb Pakhanbhed (Bergenia ciliata, Haw.). Food Chem 106: 247-252. https://doi.org/10.1016/j.foodchem.2007.05.077
  21. Puls W, Keup U, Krause HP, Thomas G, Hoffmeister F. 1977. Glucosidase inhibition. A new approach to the treatment of diabetes, obesity, and hyperlipoproteinaemia. Naturwissenschaften 64: 536-537. https://doi.org/10.1007/BF00483562
  22. Babu PS, Srinivasan K. 1997. Influence of dietary capsaicin and onion on the metabolic abnormalities associated with streptozotocin induced diabetes mellitus. Mol Cell Biochem 175: 49-57. https://doi.org/10.1023/A:1006881027166
  23. El-Demerdash FM, Yousef MI, El-Naga NI. 2005. Biochemical study on the hypoglycemic effects of onion and garlic in alloxan-induced diabetic rats. Food Chem Toxicol 43: 57-63. https://doi.org/10.1016/j.fct.2004.08.012
  24. Akhani SP, Vishwakarma SL, Goyal RK. 2004. Anti-diabetic activity of Zingiber officinale in streptozotocin-induced type I diabetic rats. J Pharm Pharmacol 56: 101-105.
  25. Sekiya K, Ohtani A, Kusano S. 2004. Enhancement of insulin sensitivity in adipocytes by ginger. Biofactors 22: 153-156. https://doi.org/10.1002/biof.5520220130
  26. Tolan I, Ragoobirsing D, Morrison EY. 2001. The effect of capsaicin on blood glucose, plasma insulin levels and insulin binding in dog models. Phytother Res 15: 391-394. https://doi.org/10.1002/ptr.750
  27. Lebovitz HE. 1998. Postprandial hyperglycemic state: importance and consequences. Diabetes Res Clin Pract 40: 27-28. https://doi.org/10.1016/S0168-8227(98)00039-4
  28. Ratner RE. 2001. Controlling postprandial hyperglycemia. Am J Cardiol 88: 26-31. https://doi.org/10.1016/S0002-9149(01)01834-3
  29. Mosihuzzman M, Naheed S, Hareem S, Talib S, Abbas G, Khan SN, Choudhary MI, Sener B, Tareen RB, Israr M. 2013. Studies on ${\alpha}$-glucosidase inhibition and anti-glycation potential of Iris loczyi and Iris unguicularis. Life Sci 92: 187-192. https://doi.org/10.1016/j.lfs.2012.11.022
  30. Akhtar S, Benter IF. 2013. The role of epidermal growth factor receptor in diabetes-induced cardiac dysfunction. Bioimpacts 3: 5-9.
  31. Dennis JW, Laferte S, Waghorne C, Breitman ML, Kerbel RS. 1987. Beta 1-6 branching of Asn-linked oligosaccharides is directly associated with metastasis. Science 236: 582-585. https://doi.org/10.1126/science.2953071
  32. Van de Laar FA, Lucassen PL, Akkermans RP, Van de Lisdonk EH, Rutten GE, Van Weel C. 2005. Alpha-glucosidase inhibitors for type 2 diabetes mellitus. Cochrane Database Syst Rev 18: CD003639.
  33. Chiasson JL, Josse RG, Gomis R, Hanefeld M, Karasik A, LaaksoM. 2003. Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial. JAMA 290: 486-494. https://doi.org/10.1001/jama.290.4.486
  34. Yamasaki Y, Katakami N, Hayaishi-Okano R, Matsuhisa M, Kajimoto Y, Kosugi K, Hatano M, Hori M. 2005. Alphaglucosidase inhibitor reduces the progression of carotid intima-media thickness. Diabetes Res Clin Pract 67: 204-210. https://doi.org/10.1016/j.diabres.2004.07.012
  35. Egan JM, Bulotta A, Hui H, Perfetti R. 2003. GLP-1 receptor agonists are growth and differentiation factors for pancreatic islet beta cells. Diabetes Metab Res Rev 19: 115-123. https://doi.org/10.1002/dmrr.357
  36. Srinivasan K. 2005. Plant foods in the management of diabetes mellitus: spices as beneficial antidiabetic food adjuncts. Int J Food Sci Nutr 56: 399-414. https://doi.org/10.1080/09637480500512872

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