Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Heavy Metal Pollution in Sub-Saharan Africa and Possible Implications in Cancer Epidemiology

  • Fasinu, Pius Sedowhe (Division of Pharmacology, Department of Medicine, Faculty of Health Sciences, Stellenbosch University and Tygerberg Hospital) ;
  • Orisakwe, Orish Ebere (Toxicology Unit, Clinical Pharmacy Faculty of Pharmacy University of PortHarcourt Rivers State)
  • Published : 2013.06.30
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Abstract

The increasing scourge of cancer epidemiology is a global concern. With WHO emphasizing that 40% of all cancer cases are preventable, exposure to known and suspected carcinogens must be discouraged. The battle with communicable diseases and other third world challenges has greatly de-emphasized anti-cancer campaigns in sub-Saharan Africa. The abundant deposit of mineral resources in sub-Saharan Africa has attracted high mining activity with its negative environmental aftermath. Poor regulatory mechanisms have led to environmental contamination by products of mining including heavy metals. In addition to poor urban planning, the springing up of settlements in industrial areas has led to generation and exposure to more hazardous wastes consequent on poor disposal systems. Studies establishing close association between exposure to heavy metals and cancer epidemiology in sub-Saharan Africa are increasing. The current review assesses the level of environmental pollution by heavy metals in sub-Saharan Africa, and brings to the fore available evidence implicating such in the increasing cancer epidemiology in the sub-continent.

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References

  1. Abdullahi MS, Uzairu A, Harrison GFS, Balarabe ML (2007). Trace metals screening of tomatoes and onions from irrigated farmlands on the bank of river Challawa, Kano, Nigeria. EJEAFChe, 6, 1869-78.
  2. Alatise OI, Schrauzer GN (2010). Lead exposure: a contributory cause of the current breast cancer epidemic in Nigerian women. Biol Trace Elem Res, 136, 127-39. https://doi.org/10.1007/s12011-010-8608-2
  3. Bahemuka TE, Mubofu EB (1999). Heavy metals in edible green vegetables grown along the sites of the Sinza and Msimbazi rivers in Dar es Salaam, Tanzania. Food Chem, 66, 63-6. https://doi.org/10.1016/S0308-8146(98)00213-1
  4. Banza CLN, Nawrot TS, Haufroid V, et al (2009). High human exposure to cobalt and other metals in Katanga, a mining area of the Democratic Republic of Congo. Environ Res, 109, 745-52. https://doi.org/10.1016/j.envres.2009.04.012
  5. Bates MN, Garrett N, Graham B, Read D (1998). Cancer incidence, morbidity and geothermal air pollution in Rotorua, New Zealand. Int J Epidemiol, 27, 10-4. https://doi.org/10.1093/ije/27.1.10
  6. Boening DW (2005). Ecological effects, transport, and fate of mercury: a general review. Chemosphere, 40, 1335-51.
  7. Boffetta P (2004). Epidemiology of environmental and occupational cancer. Oncogene, 23, 6392-403. https://doi.org/10.1038/sj.onc.1207715
  8. Brown LM, Pottern LM, Blot WJ (1984). Lung cancer in relation to environmental pollutants emitted from industrial sources. Environ Res, 34, 250-61. https://doi.org/10.1016/0013-9351(84)90093-8
  9. Carmona ER, Creus A, Marcos R (2011). Genotoxic effects of two nickel-compounds in somatic cells of Drosophila melanogaster. Mutat Res, 718, 33-7. https://doi.org/10.1016/j.mrgentox.2010.10.008
  10. Carrigan PE, Hentz JG, Gordon G, et al (2007). Distinctive heavy metal composition of pancreatic juice in patients with pancreatic carcinoma. Cancer Epidemiol Biomarkers Prev, 16, 2656-63. https://doi.org/10.1158/1055-9965.EPI-07-0332
  11. Chandran L, Cataldo R (2010). Lead poisoning: basics and new developments. Pediatr Rev, 31, 399-405. https://doi.org/10.1542/pir.31-10-399
  12. Chen H, Giri NC, Zhang R, et al (2010). Nickel ions inhibit histone demethylase JMJD1A and DNA repair enzyme ABH2 by replacing the ferrous iron in the catalytic centers. J Biol Chem, 285, 7374-83. https://doi.org/10.1074/jbc.M109.058503
  13. Chiang CT, Lian IeB, Su CC, et al (2010). Spatiotemporal trends in oral cancer mortality and potential risks associated with heavy metal content in Taiwan soil. Int J Environ Res, 7, 3916-28.
  14. Davis AP, Shokouhian M, Ni S (2001). Loading estimates of lead, copper, cadmium, and zinc in urban runoff from specific sources. Chemosphere, 44, 997-1009. https://doi.org/10.1016/S0045-6535(00)00561-0
  15. Duruibe JO, Ogwuegbu MOC, Egwurugwu JN (2007). Heavy metal pollution and human biotoxic effects. Int J Phys Sci, 2, 112-8.
  16. Ekengele NL, Myung C, Ombolo A, et al (2008). Metal pollution in freshly deposited sediments from river Mingoa, main tributary to the Municipal lake of Yaounde, Cameroon. Geosci J, 12, 337-47. https://doi.org/10.1007/s12303-008-0034-5
  17. El-Harouny MA, El-Morsi DA, Ahmed BRA, El-Atta HMO (2011). Chronic toxicity of some heavy metals and breast cancer in egyptian females. J Clinic Toxicol, 1, 2.
  18. Emoyan OO, Ogban FE, Akarah E (2006). Evaluation of heavy metals loading of river Ijana in Ekpan-Warri, Nigeria. J Appl Sci Environ Mgt, 10, 121-7.
  19. Essumang DK (2009). Analysis and human health risk assessment of arsenic, cadmium, and mercury in manta birostris (Manta Ray) caught along the ghanaian coastline, human and ecological risk assessment. Int J, 15, 985-98.
  20. Fakayode SO, Olu-owolabi BI (2003). Heavy metal contamination of roadside topsoil in osogbo Nigeria: its relationship to traffic density and proximity to highways. Environ Geol, 44, 150-7.
  21. Fakayode SO, Onianwa PC (2002). Heavy metal contamination of soil, and bioaccumulation in guinea grass (Panicum maximum) around Ikeja industrial estate, Lagos Nigeria. Environ Geol, 43, 145-50. https://doi.org/10.1007/s00254-002-0633-9
  22. Farombi EO, Adelowo OA, Ajimoko YR (2007). Biomarkers of oxidative stress and heavy metal levels as indicators of environmental pollution in African cat fish (Clarias gariepinus) from Nigerian Ogun river. Int J Environ Res, 4, 158-65.
  23. Fatoki OS, Mathabatha S (2001). An assessment of heavy metal pollution in the East London and Port Elizabeth habours. Water SA, 27, 2.
  24. Ferlay J, Shin H, Bray F, et al (2010). Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer, 127, 2893-917. https://doi.org/10.1002/ijc.25516
  25. Fianko JR, Osae S, Adomako D, Adotey DK, Serfor-Armah Y (2007). Assessment of heavy metal pollution of the Iture Estuary in the Central region of Ghana. Environ Monit Assess, 131, 467-73. https://doi.org/10.1007/s10661-006-9492-2
  26. Flora SJ (2011). Arsenic-induced oxidative stress and its reversibility. Free Radic Biol Med, 51, 257-81. https://doi.org/10.1016/j.freeradbiomed.2011.04.008
  27. Fujiwara Y, Lee JY, Tokumoto M, Satoh M (2012). Cadmium renal toxicity via apoptotic pathways. Biol Pharm Bull, 35, 1892-7. https://doi.org/10.1248/bpb.b212014
  28. GESAM (Group of Experts on the Scientific Aspects of Marine Pollution) (2000). Joint group of experts on the scientific aspects of marine pollution. The atmospheric inputs of trace species to the world oceans. Report study GESAMP, 38, 111.
  29. Golovine K, Makhov P, Uzzo RG, et al (2010). Cadmium downregulates expression of XIAP at the post-transcriptional level in prostate cancer cells through an NF-kappaB-independent, proteasome-mediated mechanism. Mol Cancer, 9, 183. https://doi.org/10.1186/1476-4598-9-183
  30. Goodman JE, Prueitt RL, Thakali S, Oller AR (2011). The nickel ion bioavailability model of the carcinogenic potential of nickel-containing substances in the lung. Crit Rev Toxicol, 41, 142-4. https://doi.org/10.3109/10408444.2010.531460
  31. Hnizdo E, Murray J, Klempman S (1997). Lung cancer in relation to exposure to silica dust, silicosis and uranium production in South African gold miners. Thorax, 52, 271-5. https://doi.org/10.1136/thx.52.3.271
  32. Hnizdo E, Sluis-Cremer GK (1991). Silica exposure, silicon and lung cancer: a mortality study in South Africa gold miners. Br J Ind Med, 48, 53-60.
  33. Hopenhayn-Rich C, Biggs ML, Fuchs A, et al (1996). Bladder cancer mortality associated with arsenic in drinking water in Argentina. Epidemiology, 7, 117-24. https://doi.org/10.1097/00001648-199603000-00003
  34. Hossain K, Akhand AA, Kato M (2000). Arsenite induces apoptosis of murine T lymphocytes through membrane raft-linked signalling for activation of c-Jun amino termina kinase. J Immunol, 165, 4290-7. https://doi.org/10.4049/jimmunol.165.8.4290
  35. Ibeto CN, Okoye COB (2010). High levels of heavy metals in blood of the urban population in Nigeria. Res J Environ Sci, 4, 371-82. https://doi.org/10.3923/rjes.2010.371.382
  36. Jaafar R, Omar I, Jidon AJ, et al (1993). Skin cancer caused by chronic arsenical poisoning--a report of three cases. Med J Malaysia, 48, 86-92.
  37. Jarup L (2003). Hazards of heavy metal contamination. Br Med Bull, 68, 167-82. https://doi.org/10.1093/bmb/ldg032
  38. Jemal A, Bray F, Forman D, et al (2012). Cancer burden in Africa and opportunities for prevention. Cancer, 118, 4372-84. https://doi.org/10.1002/cncr.27410
  39. Jemal A, Center MM, DeSantis C, Ward EM (2010). Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol Biomarkers Prev, 19, 1893-907. https://doi.org/10.1158/1055-9965.EPI-10-0437
  40. Jemal A, Graubard BI, Devesa SS, Flegal KM (2002). The association of blood lead level and cancer mortality among whites in the United States. Environ Health Perspect, 110, 325-9. https://doi.org/10.1289/ehp.02110325
  41. Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
  42. Karagas MR, Andrew AS, Nelson HH, et al (2012). SLC39A2 and FSIP1 polymorphisms as potential modifiers of arsenicrelated bladder cancer. Human genetics, 131, 453-61. https://doi.org/10.1007/s00439-011-1090-x
  43. Khlifi R, Hamza-Chaffai A (2010). Head and neck cancer due to heavy metal exposure via tobacco smoking and professional exposure: a review. Toxicol Appl Pharmacol, 248, 71-88. https://doi.org/10.1016/j.taap.2010.08.003
  44. Kim M, Kim K (2011). Biomonitoring of lead and cadmium in the hair and fingernails of elderly Korean subjects. Biol Trace Elem Res, 143, 794-802. https://doi.org/10.1007/s12011-010-8942-4
  45. Kishe MA, Machiwa JF (2003). Distribution of heavy metals in sediments of Mwanza gulf of Lake Victoria Tanzania. Environ Int, 28, 619-25. https://doi.org/10.1016/S0160-4120(02)00099-5
  46. Klatka J, Remer M, Dobrowolski R, et al (2011). The content of cadmium, cobalt and nickel in laryngeal carcinoma. Arch Med Sci, 7, 517-22.
  47. Kriegel AM, Soliman AS, Zhang Q, et al (2006). Serum cadmium levels in pancreatic cancer patients from the East Nile Delta region of Egypt. Environ Health Perspect, 114, 113-9. https://doi.org/10.1289/ehp.114-a113
  48. Kwadwo AA, Tetsuro A, Annamalai S, et al (2007). Contamination status of arsenic and other trace elements in drinking water and residents from Tarkwa, a historic mining township in Ghana. Chemosphere, 66, 1513-22. https://doi.org/10.1016/j.chemosphere.2006.08.022
  49. Lemos VA, de Carvalho AL (2010). Determination of cadmium and lead in human biological samples by spectrometric techniques: a review. Environ Monit Assess, 171, 255-65. https://doi.org/10.1007/s10661-009-1276-z
  50. Liu SS, Lu DP (2010). Cytotoxicity of arsenic trioxide on KB cells and Tca8113 cells by SRB assay. J Oral Maxillofac Surg, 1, 6.
  51. Malvezzi M, Bertuccio P, Levi F, La Vecchia C, Negri E (2013). European cancer mortality predictions for the year 2013. Ann Oncol, 24, 792-800. https://doi.org/10.1093/annonc/mdt010
  52. McGlashan ND (1969). Oesophageal cancer and alcoholic spirits in central Africa. Gut, 10, 643-50. https://doi.org/10.1136/gut.10.8.643
  53. McGlashan ND, Harington JS, Chelkowska E (2003). Changes in the geographical and temporal patterns of cancer incidence among black gold miners working in South Africa 1964-1996. Br J Cancer, 88, 1361-9. https://doi.org/10.1038/sj.bjc.6600841
  54. Meck M, Love D, Mapani B (2006). Zimbabwean mine dumps and their impacts on river water quality - a reconnaissance study. Physics and Chemistry of the Earth, 31, 797-803. https://doi.org/10.1016/j.pce.2006.08.029
  55. Mireji Po, Keating J, Hassanali A, et al (2008). Heavy metals in mosquito larval habitats in urban Kisumu and Malindi Kenya and their impacts. Ecotoxicol Environ Safety, 70, 147-53. https://doi.org/10.1016/j.ecoenv.2007.03.012
  56. Mombeshora C, Ajayi SO, Osibanjo O (1998). Pollution studies on Nigerian rivers: toxic heavy metal status of surface waters in Ibadan city. Environ Int, 5, 49-53.
  57. Muchuweti M, Birkett JW, Chinyanga E, et al (2006). Heavy metal content of vegetables irrigated with mixtures of wastewater and sewage sludge in Zimbabwe: implications for human health. Agric Ecosyst Environ, 112, 41-8. https://doi.org/10.1016/j.agee.2005.04.028
  58. Muwanga A, Barifaijo E (2006). Impact of industrial activities on heavy metal loading and their physico-chemical effects on wetlands of Lake Victoria basin (Uganda). Afr J Sci Tech, 7, 51-63.
  59. Nabulo G, Oryem OH, Diamond M (2006). Assessment of lead, cadmium and zinc contamination of roadside soils, surface films and vegetables in Kampala city, Uganda. Environ Res, 101, 42-52. https://doi.org/10.1016/j.envres.2005.12.016
  60. Nair AR, Degheselle O, Smeets K, Van Kerkhove E, Cuypers A (2013). Cadmium-Induced Pathologies: Where Is the Oxidative Balance Lost (or Not)? Int J Mol Sci, 14, 6116-43. https://doi.org/10.3390/ijms14036116
  61. Nawrot T, Plusquin M, Hogervorst J, et al (2006). Environmental exposure to cadmium and risk of cancer: a prospective population-based study. Lancet Oncol, 7, 119-26. https://doi.org/10.1016/S1470-2045(06)70545-9
  62. Nemmiche S, Chabane-Sari D, Kadri M, Guiraud P (2011). Cadmium chloride-induced oxidative stress and DNA damage in the human Jurkat T cell line is not linked to intracellular trace elements depletion. Toxicol In Vitro, 25, 191-8. https://doi.org/10.1016/j.tiv.2010.10.018
  63. Nriagu J, Afeiche M, Linder A, et al (2008). Lead poisoning associated with malaria in children of urban areas of Nigeria. Int J Hyg Environ Health, 5, 591-605.
  64. Ntekim EEU, Ekwere SJ, Ukpong EE (1993). Heavy metal distribution in sediments from Calabar river, southeastern Nigeria. Environ Geol, 21, 237-41. https://doi.org/10.1007/BF00775913
  65. Oberg M, Jaakkola MS, Woodward A, Peruga A, Pruss-Ustun A (2011). Worldwide burden of disease from exposure to second-hand smoke: a retrospective analysis of data from 192 countries. Lancet, 377, 139-46. https://doi.org/10.1016/S0140-6736(10)61388-8
  66. Obi E, Akunyili DN, Ekpo B Orisakwe OE (2006). Heavy metal hazards of Nigerian herbal remedies. Science of the Total Environment, 369, 35-41. https://doi.org/10.1016/j.scitotenv.2006.04.024
  67. Obiri S, Dodoo DK, Okai-Sam F, Essumang DK, Adjorlolo- Gasokpoh A (2006). Cancer and non-cancer health risk from eating cassava grown in some mining communities in Ghana. Environ Monit Assess, 118, 37-49. https://doi.org/10.1007/s10661-006-0799-9
  68. Odai SN, Mensah E, Sipitey D, Ryo S, Awuah E (2008). Heavy metals uptake by vegetables cultivated on urban waste dumbsites: case study of Kumasi, Ghana. Res J Environ Toxicol, 2, 92-9. https://doi.org/10.3923/rjet.2008.92.99
  69. Oze G, Oze R, Anunuso C, et al (2006). Heavy metal pollution of fish of Qua-Iboe river estuary: possible implications for neurotoxicity. Internet J Toxicol, 3, 1.
  70. Pant HH, Rao MV (2010). Evaluation of in vitro anti-genotoxic potential of melatonin against arsenic and fluoride in human blood cultures. Ecotoxicol Environ Saf, 73, 1333-7. https://doi.org/10.1016/j.ecoenv.2010.05.004
  71. Parkin DM (2006). The evolution of the population-based cancer registry. Nat Rev Cancer, 6, 603-12. https://doi.org/10.1038/nrc1948
  72. Parkin DM, Sitas F, Chirenje M, et al (2008). Part I: Cancer in indigenous Africans - burden,distribution and trends. Lancet Oncol, 9, 683-92. https://doi.org/10.1016/S1470-2045(08)70175-X
  73. Parkin DM, Sitas F, Chirenje M, et al (2008). Part II: Cancer in indigenous Africans - causes and control. Lancet Oncol, 9, 786-95. https://doi.org/10.1016/S1470-2045(08)70198-0
  74. Parkin DM, Vizcaino AP, Skinner ME, Ndhlovu A (1994). Cancer patients and risk factors in the African population of south western Zimbabwe, 1963-1877. Cancer Epidemiol Biomakers Prev, 3, 537.
  75. Pettersson UT, Ingri J (2001). The geochemistry of Co and Cu in the Kafue river as it drains the Copperbelt mining area, Zambia. Chem Geol, 177, 399-414. https://doi.org/10.1016/S0009-2541(00)00422-8
  76. Pra D, Franke SI, Henriques JA, Fenech M (2012). Iron and genome stability: an update. Mutat Res, 733, 92-9. https://doi.org/10.1016/j.mrfmmm.2012.02.001
  77. Prabu PC (2009). Impact of heavy metal contamination of Akaki river of Ethiopia on soil and metal toxicity on cultivated vegetable crops. EJEAFChe, 8, 818-27.
  78. Quaglia A, Lillini R, Crocetti E, et al (2013). Incidence and mortality trends for four major cancers in the elderly and middle-aged adults: An international comparison. Surg Oncol, [Epub ahead of print].
  79. Rasmussen L, Andersen KJ (2003). Environmental health and human exposure assessment. In: World Health Organization, UNICEF, editors. Arsenic in drinking water. IWA London, 67, 168.
  80. Ravenscroft P, Brammer H, Richards K (2011). Arsenic pollution: a global synthesis (Vol. 94). Wiley-Blackwell.
  81. Rollin HB, Rudge CVC, Thomassen Y, Mathee A, Odland JO (2009). Levels of toxic and essential metals in maternal and umbilical cord blood from selected areas of South Africa - results of a pilot study. J Environ Monit, 11, 618-27. https://doi.org/10.1039/b816236k
  82. Said L, Banni M, Kerkeni A, Said K, Messaoudi I (2010). Influence of combined treatment with zinc and selenium on cadmium induced testicular pathophysiology in rat. Food Chem Toxicol, 48, 2759-65. https://doi.org/10.1016/j.fct.2010.07.003
  83. Sassman E (2011). Types of cancer prevalent in South Africa: Cancer Association of South Africa. Health-e News. http://www.health- e.org.za/uploaded/00ceee132303b08c2e8a6f7 3622517e6.pdf (Accessed April 3rd, 2013).
  84. Scheinberg A, Spies S, Simpson MH, Mol AP (2011). Assessing urban recycling in low-and middle-income countries: Building on modernised mixtures. Habitat Int, 35, 188-98 https://doi.org/10.1016/j.habitatint.2010.08.004
  85. Schulz EJ (1967). Arsenic as a cause of skin cancer with notes on its occurrence in Pretoria. S Afr Med J, 41, 819-22
  86. Schwerdtle T, Ebert F, Thuy C, et al (2010). Genotoxicity of soluble and particulate cadmium compounds: impact on oxidative DNA damage and nucleotide excision repair. Chem Res Toxicol, 23, 432-42. https://doi.org/10.1021/tx900444w
  87. Siegel R, Naishadham D, Jemal A (2012). Cancer statistics, 2012. CA: Cancer J Clinicians, 62, 10-29. https://doi.org/10.3322/caac.20138
  88. South African Medical Research Council. Initial Burden of disease estimates for South Africa, 2000. Pretoria; 2003. http://www.mrc.ac.za/bod/initialbodestimates.pdf (Accessed April 3rd 2013).
  89. Su C, Lin YY, Chang T, et al (2010). Incidence of oral cancer in relation to nickel and arsenic concentrations in farm soils of patients' residential areas in Taiwan. BMC Public Health, 10, 67. https://doi.org/10.1186/1471-2458-10-67
  90. Su CC, Tsai KY, Hsu YY, Lin YY, Lian IeB (2010). Chronic exposure to heavy metals and risk of oral cancer in Taiwanese males. Oral Oncol, 46, 586-90. https://doi.org/10.1016/j.oraloncology.2010.05.001
  91. Su Y, Peng F, Jiang Z, et al (2011). In vivo distribution, pharmacokinetics, and toxicity of aqueous synthesized cadmium-containing quantum dots. Biomaterials, 32, 5855-62. https://doi.org/10.1016/j.biomaterials.2011.04.063
  92. Sylla BS, Wild CP (2011). A million africans a year dying from cancer by 2030: What can cancer research and control offer to the continent? Int J Cancer, [Epub ahead of print].
  93. Taylor MP, Kesterton RGH (2002). Heavy metal contamination of an arid river environment: Gruben river, Namibia. Geomorphology, 42, 311-27. https://doi.org/10.1016/S0169-555X(01)00093-9
  94. Templeton DM, Liu Y (2010). Multiple roles of cadmium in cell death and survival. Chem Biol Interact, 188, 267-75. https://doi.org/10.1016/j.cbi.2010.03.040
  95. Thakur JS, Rao BT, Rajwanshi A, Parwana HK, Kumar R (2008). Epidemiological study of high cancer among rural agricultural community in Punjab in Northern India. Int J Environ Res, 5, 399-407.
  96. United Nation Environment Programme (UNEP) (2011). Environmental Assessment of Ogoniland. Available on http://postconflict.unep.ch/publications/OEA/UNEP_OEA.pdf.
  97. United Nations Environment Program, UNEP (2007). Environmental pollution and impacts on public health: implications of the Dandora municipal dumping site in Nairobi, Kenya. Available online http://www.unep.org/urban_environment/PDFs/DandoraWasteDump-ReportSummary.pdf (Accessed April 4th 2013).
  98. Uthus EO (2003). Arsenic essentiality: a role affecting methionine metabolism. J Trace Elem Exp Med, 16, 345-55. https://doi.org/10.1002/jtra.10044
  99. Verougstraetea V, Lisona D, Hotzb P (2003). Cadmium, lung and prostate cancer: a systematic review of recent epidemiological data. J Toxicol Environ Health, 6, 227-55. https://doi.org/10.1080/10937400306465
  100. Vinken M, Ceelen L, Vanhaecke T, Rogiers V (2010). Inhibition of gap junctional intercellular communication by toxic metals. Chem Res Toxicol, 23, 1862-67. https://doi.org/10.1021/tx100276f
  101. Von der Heyden CJ, New MG (2004). Sediment chemistry: a history of mine contaminant remediation and an assessment of processes and pollution potential. J Geochem Explor, 82, 35-57. https://doi.org/10.1016/j.gexplo.2003.11.001
  102. Waisberg M, Joseph P, Hale B, Beyersmann D (2003). Molecular and cellular mechanisms of cadmium carcinogenesis. Toxicology, 192, 95-117. https://doi.org/10.1016/S0300-483X(03)00305-6
  103. Wang M, Song H, Chen W, et al (2011). Cancer mortality in a Chinese populationsurrounding a multi-metal sulphide mine in Guangdong province: an ecologic study. BMC Public Health, 11, 319. https://doi.org/10.1186/1471-2458-11-319
  104. Wilcox AJ, Savitz DA, Samet JM (2008). A tale of two toxicants: lessons from Minamata and Liaoning. Epidemiology, 19, 1-2. https://doi.org/10.1097/EDE.0b013e31815caa38
  105. Witkiewicz-Kucharczyk A, Bal W (2005). Damage of zinc fingers in DNA repair proteins, a novel molecular mechanism in carcinogenesis. Toxicol Lett, 162, 29-42.
  106. World Health Organization (1996). Trace elements in human nutrition and health. World Health Organization, Geneva.
  107. World Health Organization (2007). The World Health organization's fight against cancer: strategies that prevent, cure and care. http://www.who.int/cancer/publicat/WHOCancerBrochure2007.FINALweb.pdf (Accessed April 3rd, 2013).
  108. World health organization (2013). Cancer control: Knowledge into action - WHO Guide for Effective Programmes. http://www.who.int/cancer/en/
  109. Yasaei H, Gilham E, Pickles JC,et al (2013). Carcinogen-specific mutational and epigenetic alterations in INK4A, INK4B and p53 tumour-suppressor genes drive induced senescence bypass in normal diploid mammalian cells. Oncogene, 32, 171-9. https://doi.org/10.1038/onc.2012.45

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