Journal of the Korean Magnetic Resonance Society (한국자기공명학회논문지)

Korean Magnetic Resonance Society (한국자기공명학회)
권호 표지
DOI QR코드

DOI QR Code

Four sesquiterpenes isolated from a Marine Sponge Topsentia species

  • Rho, Jung-Rae (Department of Marine Biotechnology, Kunsan National University)
  • Received : 2014.11.10
  • Accepted : 2014.12.11
  • Published : 2014.12.20
Download PDF
⟨ Previous Next ⟩

Abstract

Three bicyclic and one monocyclic sesquiterpenoids were isolated from the marine sponge Topsentia species. Their planar structures were completely determined from a combination of extensive 1D and 2D NMR experiments, and also the relative stereochemistry on the chiral centers were established by the ROESY experiment. Compound 1 was determined as a new stereoisomer. Furthermore, the NMR spectral data for compounds 2 and 4, of which have not been reported, were listed. Four compounds did not show any cytotoxicity, instead compound 4 exhibited moderate antifungal activity against Candida albicans.

Keywords

References

  1. C. W. J. Chang, P. J. Scheuer In Topics in Current Chemistry;Scheuer, P. J., Ed.; Springer-Verlag: Berlin, 33-75 (1993).
  2. M. J. Garson, J. S. Simpson, Nat. Prod. Rep., 21, 164-179 (2004). https://doi.org/10.1039/b302359c
  3. E. Manzo, M. L. Ciavatta, M. Gavagnin, E. Mollo, Y.-W. Guo, G. J. Cimino, J. Nat. Prod., 67, 1701-1704 (2004). https://doi.org/10.1021/np0400961
  4. H. Mitome, N. Shirato, H. Miyalka, Y. Yamada, R. W. M. van Soest, J. Nat. Prod., 67, 833-837 (2004). https://doi.org/10.1021/np030458p
  5. K. A. Alvi, L. Tenenbaum, P. Crews, J. Nat. Prod, 54, 71-78 (1991). https://doi.org/10.1021/np50073a002
  6. H. He, J. Salva, R. F. Catalos, D. J. Faulkner, J. Org. Chem., 57, 3191-3194 (1992). https://doi.org/10.1021/jo00037a042
  7. Y. Nogata, E. Yoshimura, K. Shinshima, Y. Kitano, I. Sakaguchi, Biofouling, 19, 193-196 (2003). https://doi.org/10.1080/0892701031000065963
  8. B. J. Burreson, C. Christophersen, P. J. Scheuer, J. Am. Chem. Soc., 97, 201-202 (1975). https://doi.org/10.1021/ja00834a042
  9. H. Tada, T. Tozyo, M. Shiro, J. Org. Chem., 53, 3366-3368 (1988). https://doi.org/10.1021/jo00249a048
  10. E. Zubia, M. J. Ortega, C. J. Hernandez-Guerreo, J. L. Carballo, J. Nat. Prod., 71, 608-614 (2008). https://doi.org/10.1021/np070593s

Cited by

  1. A new sesterterpenoid showing anti-inflammatory effect from the Marine Sponge Haliclona species vol.19, pp.1, 2015, https://doi.org/10.6564/JKMRS.2015.19.1.023
  2. Marine natural products vol.33, pp.3, 2016, https://doi.org/10.1039/C5NP00156K