Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
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The Current Research Methodology of Pharmacopucture for the Treatment of Animal Cancer Models in Korea

암에 대한 약침치료의 국내 동물모델 연구 현황

  • Ryu, Hee Kyoung (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Goo, Bon Hyuk (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Suk, Kyung Hwan (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Lee, Ju Hyeon (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Ryu, Soo Hyeong (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Lee, Su Yeon (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Kim, Min Jeong (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Park, Yeon Cheol (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Baek, Yong Hyeon (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Park, Dong Suk (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Seo, Byung Kwan (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Kyung Hee University)
  • 유희경 (경희대학교 한의과대학 침구의학교실) ;
  • 구본혁 (경희대학교 한의과대학 침구의학교실) ;
  • 석경환 (경희대학교 한의과대학 침구의학교실) ;
  • 이주현 (경희대학교 한의과대학 침구의학교실) ;
  • 류수형 (경희대학교 한의과대학 침구의학교실) ;
  • 이수연 (경희대학교 한의과대학 침구의학교실) ;
  • 김민정 (경희대학교 한의과대학 침구의학교실) ;
  • 박연철 (경희대학교 한의과대학 침구의학교실) ;
  • 백용현 (경희대학교 한의과대학 침구의학교실) ;
  • 박동석 (경희대학교 한의과대학 침구의학교실) ;
  • 서병관 (경희대학교 한의과대학 침구의학교실)
  • Received : 2014.10.31
  • Accepted : 2014.11.27
  • Published : 2014.12.20
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Abstract

Objectives : The purpose of this study is analyzing the current research methodology of pharmacopucture for the treatment of animal cancer models. Methods : Four electronic databases were searched for animal studies published from January 2000 to September 2014 onward using these search terms "cancer, anticancer, pharmacopuncture, beevenom". Selected articles were described about animal cancer models. The methods used to induce cancer and the outcome measures used to assess the effects of pharmacopuncture on animal cancer models were analyzed. Results : 37 articles were included. For producing animal cancer models BALB/C mice(n=22) and C57BL/6 mice(n=17) were selected. And intravenous injection of B16-F10 melanoma cells into tail vein(n=14) or intraperitoneal injection of sarcoma-180 cells(n=14) were frequently used to induce cancer. Various pharmacopunctures were injected into acupoints $CV_{12}(n=19)$, $ST_{36}(n=8)$, $BL_{18}(n=8)$ or peritoneal cavity(n=6), tumor site(n=2), tail vein(n=2). Outcome measures were categorized into anti-cancer, anti-metastasis, general condition, cytotoxicity, immune response, toxicity. Median Survival Time(MST) and increase of life span(ILS)(n=26) was frequently used for evaluating anti-cancer effects. And pulmonary colonization assay(n=13) was frequently used for evaluating anti-metastasis effects Conclusions : Based on these data, further research would be needed to ascertain the effectiveness of pharmacopuncture for treating cancer and broaden the range of clinical applications.

Keywords

References

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