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Effects of Fermented Chicory Fiber on the Improvement of Intestinal Function and Constipation

치커리 화이바 발효물의 장 기능 및 변비개선 효과

  • Shin, Sun (Chongkundang Healthcare Research Center) ;
  • Park, Sung-Sun (Chongkundang Healthcare Research Center) ;
  • Lee, Hwan-Myung (Dept. of Cosmetic Science, College of Natural Science, Hoseo University) ;
  • Hur, Jung-Mu (Chongkundang Healthcare Research Center)
  • 신선 (종근당건강(주) 연구소) ;
  • 박성선 (종근당건강(주) 연구소) ;
  • 이환명 (호서대학교 화장품과학과) ;
  • 허정무 (종근당건강(주) 연구소)
  • Received : 2013.09.10
  • Accepted : 2013.10.16
  • Published : 2014.01.31

Abstract

This study investigated the improvement effects of fermented chicory fiber (FCF) on the intestinal function and constipation. The condition of fermentation was Bifidobacterium thermophilum added into chicory fiber (CF) flour suspension with the range of a 1% before incubation at $37^{\circ}C$ for 48 hr. The intestinal improvement effect of FCF was measured by the charcoal meal transit method in Balb/c mice. The intestinal transit with FCF at a dose of 1.62 mg/g was significantly increased to 88% compared with the CF group (P<0.01). Further, the constipation relief effect was investigated in Sprague-Dawley rats with loperamide-induced constipation. After oral administration of FCF 2.06 mg/g was remarkably decreased to 75% in fecal output compared with CF group (P<0.01). These findings indicated that FCF was more effective than CF for the intestinal function and constipation.

치커리 화이바는 콜레스테롤 개선, 배변활동 원활, 식후혈당 상승억제의 기능성을 바탕으로 건강기능식품 기능성 원료로 사용되고 있다. 배변활동에 도움을 주는 치커리 화이바를 발효하여 변비개선 효능을 확인한 결과 실험기간 동안 식이 섭취량이 증가한 반면 체중이 유의적으로 감소하는 것으로 보아 비만예방에 효과가 있을 것으로 생각된다. 장 기능 개선효과를 확인하기 위해 소화관 이동률을 측정한 결과 대조군에 비해 양성 대조군 FWP(차전자피복합물), 실험군 CF(치커리 화이바), 실험군 FCF(치커리 화이바 발효물)에서 소화관 이동률이 증가하였고, 특히 실험군 FCF 1.62 mg/g (P<0.01)과 실험군 4.13 mg/g(P<0.05)의 경우 실험군 CF 동일 농도에 비해 소화관 이동률이 유의적으로 증가하였다. 또한 변비개선 효과를 확인하기 위해 대장 내 잔류하고 있는 변의 개수를 확인한 결과 변비를 유발시킨 loperamide 처리군은 대조군에 비해 대장 내에 변이 잔류하면서 배변활동이 제대로 이루어지지 않아 대장 내 변의 개수가 유의적으로 증가한 반면, 양성 대조군 FWP와 실험군 CF, 실험군 FCF에서 대장 내 변의 개수를 유의적으로 감소시켰고 특히 실험군 FCF 2.06 mg/g의 경우 실험군 CF 동일 농도에 비해 대장 내 변의 개수를 유의적으로 감소시켰다(P<0.01). 본 연구결과를 통해 치커리 화이바를 발효함으로써 배변활동 및 변비개선능이 비발효 치커리 화이바에 비하여 더욱 증진되는 것을 확인할 수 있었다. 따라서 발효된 치커리 화이바가 배변 및 변비 기능성을 증진시키는 소재로 활용될 수 있을 것으로 사료된다.

Keywords

References

  1. Corfield AP, Carroll D, Myerscouh N, Probert CS. 2001. Mucins in the gastrointestinal tract in health and disease. Front Biosci 6: 1321-1357. https://doi.org/10.2741/Corfield
  2. Shin JR, Ly SY. 2003. Dietary habits and factors related to lifestyles in constipated female students. Korean J Community Nutr 8: 675-688.
  3. Müller-Lissner S. 1999. Classification, pharmacology, and side effects of common laxatives. Ital J Gastroenterol Hepatol 31: 234-237.
  4. Myung SJ, Lee TH, Huh KC, Choi SC, Sohn CI. 2010. Diagnosis of constipation: a systematic review. Korean J Gastroenterol 55: 316-324. https://doi.org/10.4166/kjg.2010.55.5.316
  5. Hubert J, Berger M, Nepveu F, Paul F, Daydé J. 2008. Effects of fermentation on the phytochemical composition and antioxidant properties of soy germ. Food Chem 109:709-721. https://doi.org/10.1016/j.foodchem.2007.12.081
  6. Katina K, Liukkonen KH, Kaukovirta-Norja A, Adlercreutz H, Heinonen SM, Lampi AM, Pihlava JM, Poutanen K. 2007. Fermentation-induced changes in the nutritional value of native or germinated rye. J Cereal Sci 46: 348-355. https://doi.org/10.1016/j.jcs.2007.07.006
  7. Lee JS, Shin HK. 1997. Effects of addition of chicory extract on starch hydrolysis in vitro and glucose response in healthy subjects. Korean J Food Sci Technol 29: 1295-1303.
  8. Park CK, Cha JY, Jeon BS, Kim NM, Shim KH. 2000. Effects of chicory root water extracts on serum triglyceride and microsomal triglyceride transfer protein (MTP) activity in rats. J Korean Soc Food Sci Nutr 29: 518-524.
  9. Causey JL, Feirtag JM, Gallaher DD, Tungland BC, Slavin JL. 2000. Effects of dietary inulin on serum lipids, blood glucose and the gastrointestinal environment in hypercholesterolemic men. Nutr Res 20: 191-201. https://doi.org/10.1016/S0271-5317(99)00152-9
  10. Brighenti F, Casiraghi MC, Canzi E, Ferrari A. 1999. Effect of consumption of a ready-to eat breakfast cereal containing inulin on the intestinal milieu and blood lipids in healthy male volunteers. Eur J Clin Nutr 53: 726-733. https://doi.org/10.1038/sj.ejcn.1600841
  11. Sung HY, Jeoung HJ, Choi YS, Cho SH, Yun JW. 2004. Effects of chicory inulin and oligosaccharides on lipid metabolism in rats fed a high-cholesterol diet. J Korean Soc Food Sci Nutr 33: 305-310. https://doi.org/10.3746/jkfn.2004.33.2.305
  12. Jackson KG, Taylor GR, Clohessy AM, Williams CM. 1999. The effect of the daily intake of inulin on fasting lipid, insulin and glucose concentrations in middle-aged men and women. Br J Nutr 82: 23-30. https://doi.org/10.1017/S0007114599001087
  13. Hond ED, Geypens B, Ghoos Y. 2000. Effect of high perfomance chicory inulin on constipation. Nutr Res 20: 731-736. https://doi.org/10.1016/S0271-5317(00)00162-7
  14. Park UC. 2003. Diagnosis and management of functional evacuation disorders. J Korean Med Assoc 46: 581-593. https://doi.org/10.5124/jkma.2003.46.7.581
  15. Kleessen B, Schwarz S, Boehm A, Fuhrmann H, Richter A, Henle T, Krueger M. 2007. Jerusalem artichoke and chicory inulin in bakery products affect faecal microbiota of healthy volunteers. Br J Nutr 98: 540-549. https://doi.org/10.1017/S0007114507730751
  16. Octavian B, Oana Emilia C. 2012. Selection of lactic acid bacteria able to ferment inulin hydrolysates. Food Technol 36: 31-40.
  17. Jung SJ, Chae SW, Sohn HS, Kim SB, Rho JO, Baik SH, Kang MH, Kim GH, Kim MH, Kim HS, Park EJ, Heo YR, Cha YS. 2011. Actual status of constipation and life factors affecting constipation by diagnosis of rome in female university students in Korea. Korean J Nutr 44: 428-442. https://doi.org/10.4163/kjn.2011.44.5.428
  18. Blaak EE, Saris WHM. 1995. Health aspects of various digestible carbohydrates. Nutr Res 15: 1547-1573. https://doi.org/10.1016/0271-5317(95)02027-S
  19. Shin KO, Jeon JR, Lee JS, Kim JY, Lee CH, Kim SD, Yu YS, Nam DH. 2006. Lactic acid fermentation of Chinese yam (Dioscorea batatas decne) flour and its pharmacological effect on gastrointestinal function in rat model. Biotechnol Bioprocess Eng 11: 240-244. https://doi.org/10.1007/BF02932037
  20. Kim HJ, Kim SI, Han YS. 2008. Effects of sea tangle extract and sea tangle yogurt on constipation relief. Korean J Food Cookery Sci 24: 59-67.
  21. Marteau P, Jacobs H, Cazaubiel M, Signoret C, Prevel JM, Housez B. 2011. Effects of chicory inulin in constipated elderly people: a double-blind controlled trial. Int J Food Sci Nurt 62: 164-170. https://doi.org/10.3109/09637486.2010.527323

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