Journal of Korean Medical Science

Korean Acad Medical Sciences (대한의학회)
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Metastasis of Colon Cancer to Medullary Thyroid Carcinoma: A Case Report

  • Yeo, So-Jung (Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon Hospital) ;
  • Kim, Kyu-Jin (Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon Hospital) ;
  • Kim, Bo-Yeon (Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon Hospital) ;
  • Jung, Chan-Hee (Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon Hospital) ;
  • Lee, Seung-Won (Department of Otolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Bucheon Hospital) ;
  • Kwak, Jeong-Ja (Department of Pathology, Soonchunhyang University College of Medicine, Bucheon Hospital) ;
  • Kim, Chul-Hee (Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon Hospital) ;
  • Kang, Sung-Koo (Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon Hospital) ;
  • Mok, Ji-Oh (Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon Hospital)
  • Received : 2014.02.21
  • Accepted : 2014.06.12
  • Published : 2014.10.01
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Abstract

Metastasis to the primary thyroid carcinoma is extremely rare. We report here a case of colonic adenocarcinoma metastasis to medullary thyroid carcinoma in a 53-yr old man with a history of colon cancer. He showed a nodular lesion, suggesting malignancy in the thyroid gland, in a follow-up examination after colon cancer surgery. Fine needle aspiration biopsy (FNAB) of the thyroid gland showed tumor cell clusters, which was suspected to be medullary thyroid carcinoma (MTC). The patient underwent a total thyroidectomy. Using several specific immunohistochemical stains, the patient was diagnosed with colonic adenocarcinoma metastasis to MTC. To the best of our knowledge, the present patient is the first case of colonic adenocarcinoma metastasizing to MTC. Although tumor-tumor metastasis to primary thyroid carcinoma is very rare, we still should consider metastasis to the thyroid gland, when a patient with a history of other malignancy presents with a new thyroid finding.

Keywords

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