DOI QR코드

DOI QR Code

Gastric Carcinoma with Bone Marrow Metastasis: A Case Series

  • Ekinci, Ahmet Siyar (Department of Medical Oncology, Ankara Onkoloji Training and Research Hospital) ;
  • Bal, Oznur (Department of Medical Oncology, Ankara Onkoloji Training and Research Hospital) ;
  • Ozatli, Tahsin (Department of Medical Oncology, Ankara Onkoloji Training and Research Hospital) ;
  • Turker, Ibrahim (Department of Medical Oncology, Ankara Onkoloji Training and Research Hospital) ;
  • Esbah, Onur (Department of Medical Oncology, Ankara Onkoloji Training and Research Hospital) ;
  • Demirci, Ayse (Department of Medical Oncology, Ankara Onkoloji Training and Research Hospital) ;
  • Budakoglu, Burcin (Department of Medical Oncology, Ankara Onkoloji Training and Research Hospital) ;
  • Arslan, Ulku Yalcintas (Department of Medical Oncology, Ankara Onkoloji Training and Research Hospital) ;
  • Eraslan, Emrah (Department of Medical Oncology, Ankara Onkoloji Training and Research Hospital) ;
  • Oksuzoglu, Berna (Department of Medical Oncology, Ankara Onkoloji Training and Research Hospital)
  • Received : 2014.01.08
  • Accepted : 2014.02.20
  • Published : 2014.03.31

Abstract

Gastric cancer is a major cause of cancer-related mortality. At the time of diagnosis, majority of the patients usually have unresectable or metastatic disease. The most common sites of metastases are the liver and the peritoneum, but in the advanced stages, there may be metastases to any region of the body. Bone marrow is an important metastatic site for solid tumors, and the prognosis in such cases is poor. In gastric cancer cases, bone marrow metastasis is usually observed in younger patients and in those with poorly differentiated tumors. Prognosis is worsened owing to the poor histomorphology as well as the occurrence of pancytopenia. The effect of standard chemotherapy is unknown, as survival is limited to a few weeks. This report aimed to evaluate 5 gastric cancer patients with bone marrow metastases to emphasize the importance of this condition.

Keywords

References

  1. Ministry of Health, Public Health Agency Turkey. T.C. Saglik Bakanligi Türkiye Halk Sagligi Kurumu [Internet]. Ankara: Ministry of Health, Public Health Agency Turkey; 2008. Available from: http://www.kanser.gov.tr.
  2. Anner RM, Drewinko B. Frequency and significance of bone marrow involvement by metastatic solid tumors. Cancer 1977;39:1337-1344. https://doi.org/10.1002/1097-0142(197703)39:3<1337::AID-CNCR2820390349>3.0.CO;2-X
  3. Kilickap S, Erman M, Dincer M, Aksoy S, Harputluoglu H, Yalcin S. Bone marrow metastasis of solid tumors: clinicopathological evaluation of 73 cases. Turk J Cancer 2007;37:85-88.
  4. Mehdi SR, Bhatt ML. Metastasis of solid tumors in bone marrow: a study from northern India. Indian J Hematol Blood Transfus 2011;27:2:93-95.
  5. Mohanty SK, Dash S. Bone marrow metastasis in solid tumors. Indian J Pathol Microbiol 2003;46:613-616.
  6. Tasleem RA, Chowdhary ND, Kadri SM, Chowdhary QA. Metastasis of solid tumours in bone marrow: a study from Kashmir, India. J Clin Pathol 2003;56:803. https://doi.org/10.1136/jcp.56.10.803
  7. Frisch B, Bartl R, Burkhardt R. Bone marrow biopsy in clinical medicine: an overview. Haematologia (Budap) 1982;15:245-285.
  8. Penchansky L. Bone marrow biopsy in the metastatic work-up of solid tumors in children. Cancer 1984;54:1447-1448. https://doi.org/10.1002/1097-0142(19841001)54:7<1447::AID-CNCR2820540737>3.0.CO;2-8
  9. Wong KF, Chan JK, Ma SK. Solid tumour with initial presentation in the bone marrow--a clinicopathologic study of 25 adult cases. Hematol Oncol 1993;11:35-42. https://doi.org/10.1002/hon.2900110105
  10. Clifton JA, Philipp RJ, Ludovic E, Fowler WM. Bone marrow and carcinoma of the prostate. Am J Med Sci 1952;224:121-130. https://doi.org/10.1097/00000441-195208000-00001
  11. Finklestein JZ, Ekert H, Isaacs H Jr, Higgins G. Bone marrow metastases in children with solid tumors. Am J Dis Child 1970;119:49-52.
  12. Kim HS, Yi SY, Jun HJ, Lee J, Park JO, Park YS, et al. Clinical outcome of gastric cancer patients with bone marrow metastases. Oncology 2007;73:192-197. https://doi.org/10.1159/000127386
  13. Kusumoto H, Haraguchi M, Nozuka Y, Oda Y, Tsuneyoshi M, Iguchi H. Characteristic features of disseminated carcinomatosis of the bone marrow due to gastric cancer: the pathogenesis of bone destruction. Oncol Rep 2006;16:735-740.
  14. Kwon JY, Yun J, Kim HJ, Kim KH, Kim SH, Lee SC, et al. Clinical outcome of gastric cancer patients with bone marrow metastases. Cancer Res Treat 2011;43:244-249. https://doi.org/10.4143/crt.2011.43.4.244
  15. Ahn JB, Ha TK, Kwon SJ. Bone metastasis in gastric cancer patients. J Gastric Cancer 2011;11:38-45. https://doi.org/10.5230/jgc.2011.11.1.38
  16. Nishidoi H, Koga S. Clinicopathological study of gastric cancer with bone metastasis. Gan To Kagaku Ryoho 1987;14:1717-1722.
  17. Kong JH, Lee J, Yi CA, Park SH, Park JO, Park YS, et al. Lung metastases in metastatic gastric cancer: pattern of lung metastases and clinical outcome. Gastric Cancer 2012;15:292-298. https://doi.org/10.1007/s10120-011-0104-7
  18. Ajani JA, Moiseyenko VM, Tjulandin S, Majlis A, Constenla M, Boni C, et al; V-325 Study Group. Clinical benefit with docetaxel plus fluorouracil and cisplatin compared with cisplatin and fluorouracil in a phase III trial of advanced gastric or gastroesophageal cancer adenocarcinoma: the V-325 Study Group. J Clin Oncol 2007;25:3205-3209. https://doi.org/10.1200/JCO.2006.10.4968

Cited by

  1. Synergistic Anti-tumor Effect of KLF4 and Curcumin in Human Gastric Carcinoma Cell Line vol.15, pp.18, 2014, https://doi.org/10.7314/apjcp.2014.15.18.7747
  2. Infiltrating Mast Cells Correlate with Angiogenesis in Bone Metastases from Gastric Cancer Patients vol.16, pp.2, 2014, https://doi.org/10.3390/ijms16023237
  3. Development and Validation of a Prognostic Score to Predict Survival in Adult Patients With Solid Tumors and Bone Marrow Metastases vol.94, pp.23, 2014, https://doi.org/10.1097/md.0000000000000966
  4. Targeting mast cells in gastric cancer with special reference to bone metastases vol.21, pp.37, 2015, https://doi.org/10.3748/wjg.v21.i37.10493
  5. Pathological findings in a case of bone marrow carcinosis due to gastric cancer complicated by disseminated intravascular coagulation and thrombotic microangiopathy vol.104, pp.4, 2016, https://doi.org/10.1007/s12185-016-2051-x
  6. Base of tongue squamous cell carcinoma with infiltrative bone marrow carcinomatosis after definitive chemoradiation: A case report vol.38, pp.7, 2014, https://doi.org/10.1002/hed.24155
  7. Metastasis of solid tumors into bone marrow - Single center experience vol.48, pp.2, 2014, https://doi.org/10.1016/j.achaem.2017.05.001
  8. Recurrent gastric cancer metastasizing to the bone marrow detected on 18F-fluorodeoxyglucose positron emission tomography/contrast-enhanced computed tomography scan vol.36, pp.4, 2014, https://doi.org/10.4103/ijnm.ijnm_64_21