Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Hepatoprotective Effect of Aged Black Garlic Extract in Rodents

  • Shin, Jung Hyu (Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee, Chang Woo (Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Oh, Soo Jin (Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Yun, Jieun (Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Kang, Moo Rim (Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Han, Sang-Bae (College of Pharmacy, Chungbuk National University) ;
  • Park, Heungsik (Novarex Co., Ltd.) ;
  • Jung, Jae Chul (Novarex Co., Ltd.) ;
  • Chung, Yoon Hoo (Namhaegun Blackgarlic Co., Ltd) ;
  • Kang, Jong Soon (Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology)
  • Received : 2014.03.18
  • Accepted : 2014.03.26
  • Published : 2014.03.31
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Abstract

In this study, we investigated the hepatoprotective effects of aged black garlic (ABG) in rodent models of liver injury. ABG inhibited carbon tetrachloride-induced elevation of aspartate transaminase (AST) and alanine transaminase (ALT), which are markers of hepatocellular damage, in SD rats. D-galactosamine-induced hepatocellular damage was also suppressed by ABG treatment. However, ABG does not affect the elevation of alkaline phosphatase (ALP), a marker of hepatobilliary damage, in rats treated with carbon tetrachloride or D-galactosamine. We also examined the effect of ABG on high-fat diet (HFD)-induced fatty liver and subsequent liver damage. ABG had no significant effect on body weight increase and plasma lipid profile in HFD-fed mice. However, HFD-induced increase in AST and ALT, but not ALP, was significantly suppressed by ABG treatment. These results demonstrate that ABG has hepatoprotective effects and suggest that ABG supplementation might be a good adjuvant therapy for the management of liver injury.

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References

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