Journal of agricultural medicine and community health (농촌의학ㆍ지역보건)

Korean Society for Rural Medicine and Community Health (한국농촌의학지역보건학회)
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The Relationship between Coronary Risk Factors and Coronary Calcium Score Detected by Computed Tomography Coronary Angiography in Korean Middle Aged Men

다중절편 방사선단층촬영 결과에 기반한 한국 중년 남성에서의 관상동맥 석회화와 심혈관질환 위험인자와의 연관성

  • Park, Seung-Hyun (Department of Occupational & Environmental Medicine, Samsung Changwon Hospital, College of Medicine, Sungkyunkwan University) ;
  • Kim, Young-Wook (Department of Occupational & Environmental Medicine, Samsung Changwon Hospital, College of Medicine, Sungkyunkwan University) ;
  • Chae, Chang-Ho (Department of Occupational & Environmental Medicine, Samsung Changwon Hospital, College of Medicine, Sungkyunkwan University) ;
  • Kim, Ja-Hyun (Department of Occupational & Environmental Medicine, Samsung Changwon Hospital, College of Medicine, Sungkyunkwan University) ;
  • Kang, Yune-Sik (Department of Preventive Medicine, School of Medicine, Gyeongsang National University & Institute of Health Sciences) ;
  • Park, Yong Whi (Department of Internal Medicine, School of Medicine, Gyeongsang National University & Institute of Health Sciences) ;
  • Jeong, Baek Geun (Department of Preventive Medicine, School of Medicine, Gyeongsang National University & Institute of Health Sciences)
  • 박승현 (성균관대학교 의과대학 삼성창원병원 직업환경의학과) ;
  • 김영욱 (성균관대학교 의과대학 삼성창원병원 직업환경의학과) ;
  • 채창호 (성균관대학교 의과대학 삼성창원병원 직업환경의학과) ;
  • 김자현 (성균관대학교 의과대학 삼성창원병원 직업환경의학과) ;
  • 강윤식 (경상대학교 의학전문대학원 예방의학교실 및 건강과학연구원) ;
  • 박용휘 (경상대학교 의학전문대학원 내과학교실 및 건강과학연구원) ;
  • 정백근 (경상대학교 의학전문대학원 예방의학교실 및 건강과학연구원)
  • Received : 2013.11.05
  • Accepted : 2014.03.05
  • Published : 2014.03.31
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Abstract

Objectives: The objective of this study was to investigate the relationship between coronary artery calcification and risk factors of cardiovascular disease with multidetector computed tomography. Methods: Data were collected from 5,899 males between 30 and 59 years old by interview, survey, physical examination, blood test, and multidetector computed tomography in the university hospital from January 2010 to December 2011. We confirmed the coronary artery calcium scores of subjects by multidetector computed tomography and identified risk factors of cardiovascular disorders. We investigated the relationship between coronary artery calcification and risk factors of cardiovascular disorders. Results: Mean calcium score of the coronary arteries in 5,899 participants was 8.20, and 773 participants (13.1%) exhibited coronary artery calcification. The presence of coronary artery calcification was correlated to risk factors of cardiovascular disease (age, blood pressure, triglyceride, HDL cholesterol, LDL cholesterol, glucose, Apolipoprotein A-1, Apolipoprotein B, body mass index, waist circumference) and risk assessment tools of cardiovascular disorders. Significant predicted factors of coronary artery calcification had different patterns in each age group (30-39, 40-49, 50-59 years old). Conclusions: We confirmed the relationship between coronary artery calcification and either typical risk factors of cardiovascular disease or risk assessment tools of cardiovascular disease. In addition, we also observed that the pattern of these factors varied according to age. Therefore, age-related variation needs to be considered in management strategies to prevent cardiovascular disease.

본 연구는 다중절편 방사선단층촬영을 이용하여 관상동맥 석회화와 심혈관질환 위험인자와의 관련성에 관하여 알아보기 위하여 수행되었다. 이를 위하여 일개 대학병원에서 2010년 1월부터 2011년 12월까지 다중절편 방사선단층촬영을 시행한 30~59세의 성인 남성 5,899명을 대상으로 문진, 설문, 신체계측, 혈액검사 등을 시행하였다. 다중절편 방사선단층촬영 영상을 통해 대상자의 관상동맥 칼슘 점수를 확인하고, 기존의 심혈관질환 위험인자에 대해 확인하였다. 대상자 5,899명의 평균 관상동맥 칼슘 점수는 8.20이었고, 773명(13.1%)에서 관상동맥 석회화가 관찰되었다. 관상동맥 석회화 유무와 알려진 심혈관질환 위험인자(나이, 혈압, 공복혈당, 콜레스테롤, 아포지방단백, 비만)는 유의한 관련성을 보였으며, 심혈관질환 발병 위험도평가도구들과도 유의한 관련성이 있었다. 30-39세, 40-49세, 50-59세의 연령 군에서 관상동맥 석회화와 통계적으로 유의한 관련 요인은 각기 다른 양상을 나타냈다. 본 연구를 통하여 관상동맥 석회화와 전통적인 심혈관질환 위험인자와의 관련성 및 심혈관질환 발병위험도 평가도구와의 관련성을 확인할 수 있었다. 또한 연령 군에 따라 각기 다른 양상의 위험인자를 확인할 수 있었다. 따라서 향후 심혈관질환 예방을 위한 관리전략 수립에 연령에 따른 차이를 고려한 접근이 필요할 것으로 사료된다.

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