Factors Associated with Quality of Life of Family Caregivers in Terminally Ill Cancer Patients

말기암 환자 가족보호자의 삶의 질에 영향을 미치는 요인

  • Kim, Seon Young (Mental Health Clinic, Chonnam National University Hwasun Hospital) ;
  • Kim, Jae Min (Departments of Psychiatry, Chonnam National University Medical School) ;
  • Kim, Sung Wan (Departments of Psychiatry, Chonnam National University Medical School) ;
  • Kang, Hee Ju (Departments of Psychiatry, Chonnam National University Medical School) ;
  • Lee, Ju Yeon (Departments of Psychiatry, Chonnam National University Medical School) ;
  • Shin, Il Seon (Departments of Psychiatry, Chonnam National University Medical School) ;
  • Shim, Hyun Jeong (Department of Hemato-Oncology, Chonnam National University Medical School) ;
  • Yoon, Jin Sang (Departments of Psychiatry, Chonnam National University Medical School)
  • 김선영 (화순전남대학교병원 정신건강클리닉) ;
  • 김재민 (전남대학교 의과대학 정신건강의학교실) ;
  • 김성완 (전남대학교 의과대학 정신건강의학교실) ;
  • 강희주 (전남대학교 의과대학 정신건강의학교실) ;
  • 이주연 (전남대학교 의과대학 정신건강의학교실) ;
  • 신일선 (전남대학교 의과대학 정신건강의학교실) ;
  • 심현정 (전남대학교 의과대학 혈액종양내과학교실) ;
  • 윤진상 (전남대학교 의과대학 정신건강의학교실)
  • Received : 2014.09.03
  • Accepted : 2014.11.15
  • Published : 2014.12.31

Abstract

Objectives:The primary purpose of the present study was to assess the factors associated with quality of life(QoL) of the family caregivers of terminally ill cancer patients. Methods:A broad range of factors related to the patient-family caregiver dyad was investigated in a palliative care setting using a cross-sectional design. Caregiver QoL was assessed by the EuroQoL-5 dimensions-visual analog scale (EQ-VAS). The independent variables included patient- and caregiver-related sociodemographic and psychological factors such as depressive symptoms, subjective burden, and coping style. The clinical data of the patients were also obtained from their medical charts or gathered using measurements on face-to face interview. Multivariate linear regression analyses were conducted to identify the influences of individual factors on caregiver QoL. Results:Of 304 analyzed dyads, multivariate analyses revealed that the psychological factors of the caregivers were significantly related to their QoL. Greater levels of depressive symptoms and subjective burden in the caregiver were significantly associated with a lower QoL, but an active coping style was associated with a higher QoL. Caregivers with a physical illness reported a lower QoL than those without an illness. However, patient-related factors were not related to caregiver QoL. Conclusions:Caregiver's psychological factors rather than patient's factors are significantly related with caregiver's QoL. Providing psychiatric screening and intervention for depression and caregiver support programs for burden and coping style are recommended for enhancing QoL in caregivers of terminally ill cancer patients.

목 적 : 본 연구는 국내의 말기 암 환자 보호자의 삶의 질에 영향을 미치는 요인을 파악하기 위해 시행되었다. 방 법 : 완화병동에 입원 중인 말기 암환자-가족보 호자 쌍을 대상으로 임상적, 사회인구학적, 정신의학적 요인 등 광범위한 요인을 단면적으로 조사 및 분석하였 다. 가족보호자의 삶의 질은 EuroQoL-5 dimensions-visual analog scale(EQ-VAS)로 조사되었다. 삶의 질에 영향을 미치는 독립변인은 환자와 가족의 사회 인구학 적 요인, 정신의학적 요인(우울증상, 부양부담, 대처방식 등)을 평가하였다. 환자의 임상적 요인은 의무기록을 통 해 조사하거나, 면대면 면담을 통해 측정되었다. 각 독립 변인이 가족보호자의 삶의 질에 미치는 영향을 평가하기 위해 다중회귀분석을 시행하였다. 결 과 : 최종적으로 환자-가족보호자 304쌍을 분석 하였다. 다중회귀분석 결과 가족보호자의 정신의학적 요인은 보호자의 삶의 질과 매우 유의한 상관관계를 보였다. 높은 우울증상과 부양부담은 가족보호자의 낮은 삶 의 질과 관련되었다. 반면, 가족보호자가 적극적 대처방 식을 많이 사용하는 경우 삶의 질은 증가하였다. 가족보 호자가 신체 질환을 가지고 있는 경우 그렇지 않은 경 우에 비해 삶의 질이 낮았다. 한편, 환자 관련 요인은 가 족보호자의 삶의 질과 유의하게 관련되지 않았다. 결 론 : 말기 암 환자 가족보호자의 삶의 질은 환자 요인보다는 가족보호자 자신의 정신의학적 요인과 강 력하게 연관되었다. 우울증상에 대한 정신의학적 평가 및 개입, 부양부담과 대처방식에 대한 보호자 지지 프로 그램의 제공이 말기 암 환자 가족보호자의 삶의 질 향 상에 도움 될 것으로 보인다.

Keywords

Acknowledgement

Supported by : 전남대학교병원

References

  1. Korea central cancer registry. Annual report of cancer statistics in Korea in 2010; 2012. p. 19-27.
  2. Korea National Statistical Office. The cause of death statistics in 2013; 2014. p. 6-8.
  3. Heo DS. Withholding futile treatment from terminal cancer patients. Korean J Med 2001;61:465-9.
  4. Kim SY. Death and bereavement. In: Korean psychosomatic society, editors. Psychosomatic medicine. Seoul: Jipmoondang; 2012. p. 586-623.
  5. Braun M, Mikulincer M, Rydall A, Walsh A, Rodin G. Hidden morbidity in cancer: spouse caregivers. J Clin Oncol 2007;25:4829-34. https://doi.org/10.1200/JCO.2006.10.0909
  6. Grunfeld E, Coyle D, Whelan T, Clinch J, Reyno L, Earle CC, et al. Family caregiver burden: results of a longitudinal study of breast cancer patients and their principal caregivers. CMAJ 2004;170:1795-801. https://doi.org/10.1503/cmaj.1031205
  7. Kim SN, Lee DW, Kim BJ, Lee CS, Cha BS, Park CS, et al. Psychopathology and quality of life in family caregivers of patients with cancer. J Korean Soc Biol Ther Psychiatry 2010;16:102-10.
  8. Fleming DA, Sheppard VB, Mangan PA, Taylor KL, Tallarico M, Adams I, et al. Caregiving at the end of life: Perceptions of health care quality and quality of life among patients and caregivers. J Pain Symptom Manage 2006;31:407-20. https://doi.org/10.1016/j.jpainsymman.2005.09.002
  9. Hodges LJ, Humphris GM, Macfarlane G. A meta-analytic investigation of the relationship between the psychological distress of cancer patients and their carers. Soc Sci Med 2005;60:1-12. https://doi.org/10.1016/j.socscimed.2004.04.018
  10. Kristjanson LJ, Aoun S. Palliative care for families: remembering the hidden patients. Can J Psychiatry 2004;49:359-65. https://doi.org/10.1177/070674370404900604
  11. Song JI, Shin DW, Choi JY, Kang J, Baik YJ, Mo H, et al. Quality of life and mental health in family caregivers of patients with terminal cancer. Support Care Cancer 2011;19:1519-26. https://doi.org/10.1007/s00520-010-0977-8
  12. Grov EK, Dahl AA, Moum T, Fosså SD. Anxiety, depression, and quality of life in caregivers of patients with cancer in late palliative phase. Ann Oncol 2005;16:1185-91. https://doi.org/10.1093/annonc/mdi210
  13. Weitzner MA, McMillan SC, Jacobsen PB. Family caregiver quality of life: differences between curative and palliative cancer treatment settings. J Pain Symptom Manage 1999;17:418-28. https://doi.org/10.1016/S0885-3924(99)00014-7
  14. Jung JG, Kim JS, Kim SS, Kang DS, Kim SM, Lee DH, et al. Quality of life among family caregivers of terminal cancer patient. Korean J Hosp Palliat Care 2006;9:1-10.
  15. Sales E. Family burden and quality of life. Qual Life Res 2003;12 Suppl 1:33-41. https://doi.org/10.1023/A:1023513218433
  16. Yoon SJ, Kim JS, Jung JG, Kim SS, Kim S. Modifiable factors associated with caregiver burden among family caregivers of terminally ill Korean cancer patients. Support Care Cancer 2014;22:1243-50. https://doi.org/10.1007/s00520-013-2077-z
  17. Son KY, Lee CH, Park SM, Lee CH, Oh SI, Oh B, et al. The factors associated with the quality of life of the spouse caregivers of patients with cancer: a cross-sectional study. J Palliat Med 2012;15:216-24. https://doi.org/10.1089/jpm.2011.0305
  18. Chang YJ, Kwon YC, Lee WJ, Do YR, Seok LK, Kim HT, et al. Burdens, needs and satisfaction of terminal cancer patients and their caregivers. Asian Pac J Cancer Prev 2013;14:209-16. https://doi.org/10.7314/APJCP.2013.14.1.209
  19. Delgado-Guay MO, Parsons HA, Hui D, De la Cruz MG, Thorney S, Bruera E. Spirituality, religiosity, and spiritual pain among caregivers of patients with advanced cancer. Am J Hosp Palliat Care 2013;30:455-61. https://doi.org/10.1177/1049909112458030
  20. Brooks R. EuroQol: The current state of play. Health Policy 1996;37:53-72. https://doi.org/10.1016/0168-8510(96)00822-6
  21. Kim MH, Cho YS, Uhm WS, Kim S, Bae SC. Cross-cultural adaptation and validation of the Korean version of the EQ-5D in patients with rheumatic diseases. Qual Life Res 2005;14:1401-6. https://doi.org/10.1007/s11136-004-5681-z
  22. Sessler CN, Gosnell MS, Grap MJ, Brophy GM, O'Neal PV, Keane KA, et al. The Richmond Agitation-Sedation Scale: validity and reliability in adult intensive care unit patients. Am J Respir Crit Care Med 2002;166:1338-44. https://doi.org/10.1164/rccm.2107138
  23. Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 1982;5:649-55. https://doi.org/10.1097/00000421-198212000-00014
  24. De Conno F, Caraceni A, Gamba A, Mariani L, Abbattista A, Brunelli C, et al. Pain measurement in cancer patients: a comparison of six methods. Pain 1994;57: 161-6. https://doi.org/10.1016/0304-3959(94)90219-4
  25. Montgomery SA, Asberg M. A new depression scale designed to be sensitive to change. Br J Psychiatry 1979; 134:382-9. https://doi.org/10.1192/bjp.134.4.382
  26. Ahn YM, Lee KY, Yi JS, Kang MH, Kim DH, Kim JL, et al. A validation study of the Korean-version of the Montgomery-Asberg Depression Rating Scale. J Korean Neuropsychiatr Assoc 2005;44:466-76.
  27. Gort AM, March J, Gomez X, de Miguel M, Mazarico S, Ballesté J. Short Zarit scale in palliative care. Med Clin(Barc) 2005;124:651-3. https://doi.org/10.1157/13074742
  28. Kim SW, Kim JM, Stewart R, Bae KL, Yang SJ, Shin IS, et al. Correlates of caregiver burden for Korean elders according to cognitive and functional status. Int J Geriatr Psychiatry 2006;21:853-61. https://doi.org/10.1002/gps.1571
  29. Folkman S, Lazarus RS. Manual for the ways of coping questionnaire. Palo Alto: Consulting Psychologist Press. 1988. p. 1-33.
  30. Park JY. A study on the relationship among character type A & B, Ego-identity and stress coping. Graduate School of Sookmyung Women's University 1996;2:77
  31. Han Y, Yuan J, Luo Z, Zhao J, Wu J, Liu R, et al. Determinants of hopelessness and depression among Chinese hospitalized esophageal cancer patients and their family caregivers. Psychooncology 2013;22:2529-36. https://doi.org/10.1002/pon.3315
  32. Wells KB, Stewart A, Hays RD, Burnam MA, Rogers W, Daniels M, et al. The Functioning and well-being of depressed Patients: results from the medical outcomes study. JAMA 1989;262:914-9. https://doi.org/10.1001/jama.1989.03430070062031
  33. Heidari Gorji MA, Bouzar Z, Haghshenas M, Kasaeeyan AA, Sadeghi MR, Ardebil MD. Quality of life and depression in caregivers of patients with breast cancer. BMC Res Notes 2012;5:310. https://doi.org/10.1186/1756-0500-5-310
  34. Kim SY, Kim JM, Kim SW, Kang HJ, Shin IS, Shim HJ, et al. Determinants of a hopeful attitude among family caregivers in a palliative care setting. Gen Hosp Psychiatry 2014;36:165-71. https://doi.org/10.1016/j.genhosppsych.2013.10.020
  35. Brummett BH, Boyle SH, Siegler IC, Kuhn CM, Ashley-Koch A, Jonassaint CR, et al. Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region(5-HTTLPR). Behav Genet 2008; 38:34-43. https://doi.org/10.1007/s10519-007-9172-1
  36. Fegg MJ1, Brandstatter M, Kogler M, Hauke G, Rechenberg-Winter P, Fensterer V, et al. Existential behavioural therapy for informal caregivers of palliative patients: a randomised controlled trial. Psychooncology 2013;22: 2079-86. https://doi.org/10.1002/pon.3260
  37. Moussavi S, Chatterji S, Verdes E, Tandon A, Patel V, Ustun B. Depression, chronic diseases, and decrements in health: results from the World Health Surveys. Lancet 2007;370:851-8. https://doi.org/10.1016/S0140-6736(07)61415-9
  38. Teixeira RJ, Pereira MG. Psychological morbidity, burden, and the mediating effect of social support in adult children caregivers of oncological patients undergoing chemotherapy. Psychooncology 2013;22:1587-93. https://doi.org/10.1002/pon.3173
  39. Goldstein NE, Concato J, Fried TR, Kasl SV, Johnson-Hurzeler R, Bradley EH. Factors associated with caregiver burden among caregivers of ill patients with cancer. J Palliat Care 2004;20:38-43.
  40. Park CH, Shin DW, Choi JY, Kang J, Baek YJ, Mo HN, et al. Determinants of the burden and positivity of family caregivers of terminally ill cancer patients in Korea. Psychooncology 2012;21:282-90. https://doi.org/10.1002/pon.1893
  41. Folkman S, Lazarus RS. An analysis of coping in a middle-aged community sample. J Health Soc Behav 1980;21:219-39. https://doi.org/10.2307/2136617
  42. Folkman S, Lazarus RS, Dunkel-Schetter C, DeLongis A, Gruen RJ. Dynamics of a stressful encounter: cognitive appraisal, coping, and encounter outcomes. J Pers Soc Psychol 1986;50:992-1003. https://doi.org/10.1037/0022-3514.50.5.992
  43. Graven LJ, Grant JS. Coping and health-related quality of life in individuals with heart failure: an integrative review. Heart Lung 2013;42:183-94. https://doi.org/10.1016/j.hrtlng.2012.12.002
  44. Kershaw T, Northouse L, Kritpracha C, Schafenacker A, Mood D. Coping strategies and quality of life in women with advanced breast cancer and their family caregivers. Psychol Health 2004;19:139-55. https://doi.org/10.1080/08870440310001652687
  45. Kwon YC, Yun YH, Lee KH, Son KY, Park SM, Chang YJ, et al. Symptoms in the lives of terminal cancer patients: which is the most important? Oncology 2006;71:69-76. https://doi.org/10.1159/000100450