Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Anticancer Properties of Teucrium persicum in PC-3 Prostate Cancer Cells

  • Tafrihi, Majid (Department of Cell and Molecular Biology, University of Tehran) ;
  • Toosi, Samane (Department of Cell and Molecular Biology, University of Tehran) ;
  • Minaei, Tayebeh (Department of Cell and Molecular Biology, University of Tehran) ;
  • Gohari, Ahmad Reza (Medicinal Plants Research Center, Tehran University of Medical Sciences) ;
  • Niknam, Vahid (Department of Botany, School of Biology, University of Tehran) ;
  • Arab Najafi, Seyed Mahmoud (Department of Cell and Molecular Biology, University of Tehran)
  • Published : 2014.01.30
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Abstract

Crude extracts or phytochemicals obtained from some plants have potential anti-cancer properties. Teucrium persicum is an Iranian endemic plant belonging to the Lamiaceae family which has traditionally been used to relieve abdominal pains. However, the anti-cancer properties of this species of the Teucrium genus have not been investigated previously. In this study, we have used a highly invasive prostate cancer cell line, PC-3, which is an appropriate cell system to study anti-tumor properties of plants. A methanolic extract obtained from T persicum potently inhibited viability of PC-3 cells. The viability of SW480 colon and T47D breast cancer cells was also significantly decreased in the presence of the T persicum extract. Flow cytometry suggested that the reduction of cell viability was due to induction of apoptosis. In addition, the results of wound healing and gelatin zymography experiments supported anti-cell invasion activity of T persicum. Interestingly, sublethal concentrations of T persicum extract induced an epithelial-like morphology in a subpopulation of cells with an increase in E-Cadherin and ${\beta}$-Catenin protein levels at the cell membrane. These results strongly suggest that T persicum is a plant with very potent anti-tumor activity.

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References

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