Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Epidemiologic Survey of Infantile Cancer in Iran based on the Data of the Largest Pediatric Cancer Referral Center (Ali-Asghar Children Hospital), 1996-2005

  • Published : 2014.02.01
Download PDF
⟨ Previous Next ⟩

Abstract

Background: Cancer in infants younger than one year of age represents a unique problem with distinct epidemiological, clinical and genetic characteristics compared with older age groups. No report is yet available from Iran regarding epidemiological and survival rate of cancers diagnosed in this age group. Materials and Methods: The population under study comprised of patients which were diagnosed and admitted to Ali-Asghar hospital between years 1996-2005. In total, 287 infants were included in the retrospective descriptive survey. Patient files were evaluated for age of patient at the time of diagnosis, sex, geographical residence, consanguinity of parents, histological diagnosis, site of cancer involvement, type of therapy, date of last follow-up and cause of death (if applicable). Results: The average age at the time of diagnosis was 7.2 months old. The most frequent malignancy was retinoblastoma (44%), followed by leukemia (19%) and neuroblastoma (10%), with five-year overall survival rates of 77.7%, 41% and 90%, respectively Parents of 40 infants (13.9%) had consanguinity relationships. Conclusions: Although we cannot make any conclusions regarding the incidence of infant cancer subtypes based on this study, survival rates for major types were similar to the developed countries, which signifies strict adherence to standards of care in Ali-Asghar hospital, the main infant cancer care centre in Iran. A Childhood Cancer Registry with high-resolution data collection and also advanced genetic testing is advocated for in-depth analysis of variation in incidence and survival.

Keywords

References

  1. Aerts I, Lumbroso-Le Rouic L, Gauthier-Villars M, et al (2006). Retinoblastoma. Orphanet J Rare Dis, 25, 1:31. https://doi.org/10.1186/1750-1172-1-31
  2. Bacolod MD, Schemmann GS, Giardina SF, et al (2009). Emerging paradigms in cancer genetics: some important findings from high-density single nucleotide polymorphism array studies. Cancer Res, 69, 723-7. https://doi.org/10.1158/0008-5472.CAN-08-3543
  3. Bahoush GR, Arab E, Arjmandi KH, et al (2013). Neuroblastoma in Iran: an experience of 32 years at a referral childrens hospital. Asian Pac J Cancer Prev, 14, 2739-42. https://doi.org/10.7314/APJCP.2013.14.5.2739
  4. Bener A, Denic S, Al-Mazrouei M, et al (2001). Consanguinity and family history of cancer in children with leukemia and lymphomas. Cancer, 92, 1-6. https://doi.org/10.1002/1097-0142(20010701)92:1<1::AID-CNCR1284>3.0.CO;2-Y
  5. Bener A, El Ayoubi HR, Chouchane L, et al (2009). Impact of consanguinity on cancer in a highly endogamous population. Asian Pac J Cancer Prev, 10, 35-40.
  6. Chung EM, Specht CS, Schroeder JW (2007). From the archives of the AFIP: Pediatric orbit tumors and tumorlike lesions: neuroepithelial lesions of the ocular globe and optic nerve. Radiographics, 27, 1159-86. https://doi.org/10.1148/rg.274075014
  7. Davidoff AM (2010). Pediatric oncology. Semin Pediatr Surg, 19, 225-33. https://doi.org/10.1053/j.sempedsurg.2010.03.007
  8. Denic S, Frampton C, Nicholls MG (2007). Risk of cancer in an inbred population. Cancer Detect Prev, 31, 263-9. https://doi.org/10.1016/j.cdp.2007.07.006
  9. Denic S, Bener A (2001). Consanguinity decreases risk of breast cancer--cervical cancer unaffected. Br J Cancer, 85, 1675-9. https://doi.org/10.1054/bjoc.2001.2131
  10. Dimaras H, Kimani K, Dimba EA, et al (2012). Retinoblastoma. Lancet, 379, 1436-46. https://doi.org/10.1016/S0140-6736(11)61137-9
  11. Duffner PK, Horowitz ME, Krischer JP, et al (1999). The treatment of malignant brain tumors in infants and very young children: an update of the Pediatric Oncology Group experience. Neuro Oncol, 1, 152-61.
  12. Feldman JG, Lee SL, Seligman B et al (1976). Occurrence of acute leukemia in females in a genetically isolated population. Cancer, 38, 2548-50. https://doi.org/10.1002/1097-0142(197612)38:6<2548::AID-CNCR2820380644>3.0.CO;2-Y
  13. Ferrari A, Orbach D, Sultan I, et al (2012). Neonatal soft tissue sarcomas. Semin Fetal Neonatal Med, 17, 231-8. https://doi.org/10.1016/j.siny.2012.05.003
  14. Fisher JP, Tweddle DA (2012). Neonatal neuroblastoma. Semin Fetal Neonatal Med, 17, 207-15. https://doi.org/10.1016/j.siny.2012.05.002
  15. Gurney JG, Ross JA, Wall DA, et al (1997). Infant cancer in the US: histology specific incidence and trends,1973 to 1992. J Pediat Hematol Oncol, 19, 428-32. https://doi.org/10.1097/00043426-199709000-00004
  16. Hwang SW, Su JM, Jea A (2012). Diagnosis and management of brain and spinal cord tumors in the neonate. Semin Fetal Neonatal Med, 17, 202-6. https://doi.org/10.1016/j.siny.2012.03.001
  17. Knudson AG (1971). Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA, 68, 820. https://doi.org/10.1073/pnas.68.4.820
  18. Lakhoo K, Sowerbutts H (2010). Neonatal tumours. Pediatr Surg Int, 26, 1159-68. https://doi.org/10.1007/s00383-010-2738-7
  19. Li J, Thompson TD, Miller JW, et al (2008). Cancer incidence among children and adolescents in the United States, 2001-2003. Pediatrics, 121, :e1470-7 (& the website: http://www.mindfully.org/health/cancer-infants-SEER.75-79.html). https://doi.org/10.1542/peds.2007-2964
  20. Magdum SA (2010). Neonatal brain tumours - a review. Early Hum Dev, 86, 627-31. https://doi.org/10.1016/j.earlhumdev.2010.08.021
  21. Malkin D, Portwine C (1994). The genetics of childhood cancer. Eur J Cancer, 30A, 1942-1946.
  22. Mehdiabadi GB, Arab E, Rafsanjani KA, et al (2013). Neuroblastoma in iran: an experience of 32 years at a referral childrens hospital. Asian Pac J Cancer Prev, 14, 2739-42. https://doi.org/10.7314/APJCP.2013.14.5.2739
  23. McHugh K (2007). Renal and adrenal tumours in children. Cancer Imaging. 7, 41-51. https://doi.org/10.1102/1470-7330.2007.0007
  24. Michel G, von der Weid NX, Zwahlen M, et al (2007). The Swiss Childhood Cancer Registry: rationale, organisation and results for the years 2001-2005. Swiss Med Wkly, 137, 502-9.
  25. Moore SW, Satge D, Sasco AJ, Zimmermann A, et al (2003). The epidemiology of neonatal tumours.Report of an international working group. Pediatr Surg Int, 19, 509-19. https://doi.org/10.1007/s00383-003-1048-8
  26. Pieters R (2009). Infant acute lymphoblastic leukemia: Lessons learned and future directions. Curr Hematol Malig Rep, 4, 167-74. https://doi.org/10.1007/s11899-009-0023-4
  27. Pizzo PA., Poplack DG., Pizzo I (2012). Principles and Practice of Pediatric Oncology(6th edition). Lippincott Williams & Wilkins.
  28. Pollock BH, Tomlinson GE (2012). Preventing cancer in adulthood: advice for the pediatrician. In Pizzo PA., Poplack DG., Pizzo I (2012). Principles and Practice of Pediatric Oncology (6th edition). Lippincott Williams & Wilkins publications.
  29. Pui CH, Mullighan CG, Evans WE, et al (2012). Pediatric acute lymphoblastic leukemia: where are we going and how do we get there? Blood, 120, 1165-74. https://doi.org/10.1182/blood-2012-05-378943
  30. Kliegman MD, Richard E. Behrman MD et al (2007). Nelson Textbook of Pediatrics(18th edition, chapter 491). Saunders Publications.
  31. Dreyer Z, Indelicate DJ, Reaman GH, et al (2012). Infants and adolescents with cancer: special considerations. In Pizzo PA., Poplack DG., Pizzo I (2012). Principles and Practice of Pediatric Oncology(6th edition). Lippincott Williams & Wilkins publications.
  32. Swaminathan R, Rama R, Shanta V (2008). Childhood cancers in Chennai, India, 1990-2001: incidence and survival. Int J Cancer, 122, 2607-11. https://doi.org/10.1002/ijc.23428
  33. Vasilatou-Koqsmidis H (2003). Cancer in neonates and infants. Med Pediatr Oncol, 41, 7-9. https://doi.org/10.1002/mpo.10153
  34. Wiangnon S, Veerakul G, Nuchprayoon I, et al (2011). Childhood cancer incidence and survival 2003-2005, Thailand: study from the Thai Pediatric Oncology Group. Asian Pac J Cancer Prev, 12, 2215-20.

Cited by

  1. Overview of Childhood Cancers at a Regional Cancer Centre in North-East India vol.15, pp.18, 2014, https://doi.org/10.7314/APJCP.2014.15.18.7817
  2. Paediatric Retinoblastoma in India: Evidence from the National Cancer Registry Programme vol.16, pp.10, 2015, https://doi.org/10.7314/APJCP.2015.16.10.4193
  3. Epidemiology of Childhood Cancer in Northwest Iran vol.16, pp.13, 2015, https://doi.org/10.7314/APJCP.2015.16.13.5459
  4. Patterns of Childhood Cancer Incidence in Saudi Arabia (1999-2008) vol.16, pp.2, 2015, https://doi.org/10.7314/APJCP.2015.16.2.431