Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Lactobacillus plantarum HY7712 Protects Against the Impairment of NK-Cell Activity Caused by Whole-Body ${\gamma}$-Irradiation in Mice

  • Lee, Hoyong (Korea Yakult Co., Ltd.) ;
  • Ahn, Young-Tae (Korea Yakult Co., Ltd.) ;
  • Park, Se-Hoon (Korea Yakult Co., Ltd.) ;
  • Park, Do-Young (Korea Yakult Co., Ltd.) ;
  • Jin, Young-Woo (Division of Radiation Effect Research, Radiation Health Research Institute, Korea Hydro and Nuclear Power Co., Ltd.) ;
  • Kim, Cha Soon (Division of Radiation Effect Research, Radiation Health Research Institute, Korea Hydro and Nuclear Power Co., Ltd.) ;
  • Sung, Sang Hyun (College of Pharmacy, Seoul National University) ;
  • Huh, Chul-Sung (Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University) ;
  • Kim, Dong-Hyun (College of Pharmacy, Kyung Hee University)
  • Received : 2013.07.08
  • Accepted : 2013.10.07
  • Published : 2014.01.28
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Abstract

While searching for lactic acid bacteria that can restore aging-impaired immune responses, we isolated the Toll-like receptor (TLR) 2/NF-${\kappa}B$-activating strain Lactobacillus plantarum HY7712 from kimchi and investigated its immunomodulating effect in whole-body ${\gamma}$-irradiated mice. Exposure to HY7712 strongly activated NF-${\kappa}B$ signaling in RAW264.7 cells, but inhibited lipopolysaccharide-stimulated NF-${\kappa}B$ activation. Moreover, HY7712 protected against the downregulation of interferon (IFN)-${\gamma}$ and upregulation of interleukin (IL)-13 caused by ${\gamma}$-irradiation in mice. In mice, ${\gamma}$-irradiation impaired NK-cell activity against YAC-1 tumor cells, but following HY7712 exposure, the activity of NK cells was restored to 91.5% of the level measured in control mice (p < 0.05). These findings suggest that HY7712 activates the TLR2/NF-${\kappa}B$ signaling pathway and protects against the impairment of NK-cell activity caused by ${\gamma}$-irradiation or aging.

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