Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Ionizing Radiations Induce Apoptosis in TRAIL Resistant Cancer Cells: in vivo and in vitro Analysis

  • Published : 2014.03.01
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Abstract

Increasingly it is being realized that despite considerable advancements in therapeutic interventions related to treatment of cancer, satisfactory results are still difficult to achieve. Rapidly accumulating evidence has started to shed light on the fact that cancer cells escape from death via constitutive activation of pro-survival signaling cascades. Cell biology and genetics have extensively enhanced our current understanding of the molecular mechanisms that underlie loss of apoptosis in cancer cells. This review is focused on ionizing radiation mediated restoration of TRAIL mediated apoptosis as evidenced by cell culture and animal model studies. Moreover, we also bring to the limelight radiation induced expression of miRNAs and how miRNAs further control response of cancer cells to radiation.

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References

  1. Arora H, Qureshi R, Jin S, et al (2011). MiR-9 and let-7g enhance the sensitivity to ionizing radiation by suppression of NFkappaB1. Exp Mol Med, 43, 298-304. https://doi.org/10.3858/emm.2011.43.5.031
  2. Fokas E, Yoshimura M, Prevo R, et al (2012) NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/ mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity. Radiat Oncol, 7, 48. https://doi.org/10.1186/1748-717X-7-48
  3. Grosso S, Doyen J, Parks SK, et al (2013). MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines. Cell Death Dis, 4, 544. https://doi.org/10.1038/cddis.2013.71
  4. Hori T, Kondo T, Kanamori M, et al (2010). Ionizing radiation enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulations of death receptor 4 (DR4) and death receptor 5 (DR5) in human osteosarcoma cells. J Orthop Res, 28, 739-45.
  5. Kwon JE, Kim BY, Kwak SY, et al (2013). Ionizing radiationinducible microRNA miR-193a-3p induces apoptosis by directly targeting Mcl-1. Apoptosis, 18, 896-909. https://doi.org/10.1007/s10495-013-0841-7
  6. Lawrence MD, Ormsby RJ, Blyth BJ, et al (2013). Lack of high-dose radiation mediated prostate cancer promotion and low-dose radiation adaptive response in the TRAMP mouse model. Radiat Res, 180, 376-88. https://doi.org/10.1667/RR3381.2
  7. Liang Z, Ahn J, Guo D, et al (2013). MicroRNA-302 replacement therapy sensitizes breast cancer cells to ionizing radiation. Pharm Res, 30, 1008-16. https://doi.org/10.1007/s11095-012-0936-9
  8. Liu Y, Xing R, Zhang X, et al (2013). MiR-375 targets the p53 gene to regulate cellular response to ionizing radiation and etoposide in gastric cancer cells. DNA Repair, 12, 741-50. https://doi.org/10.1016/j.dnarep.2013.06.002
  9. Marini P, Budach W, Niyazi M, et al (2009). Combination of the pro-apoptotic TRAIL-receptor antibody mapatumumab with ionizing radiation strongly increases long-term tumor control under ambient and hypoxic conditions. Int J Radiat Oncol Biol Phys, 75, 198-202. https://doi.org/10.1016/j.ijrobp.2009.04.038
  10. Marini P, Schmid A, Jendrossek V, et al (2005). Irradiation specifically sensitises solid tumour cell lines to TRAIL mediated apoptosis. BMC C ancer, 5, 5. https://doi.org/10.1186/1471-2407-5-5
  11. Nagane M, Cavenee WK, Shiokawa Y (2007). Synergistic cytotoxicity through the activation of multiple apoptosis pathways in human glioma cells induced by combined treatment with ionizing radiation and tumor necrosis factorrelated apoptosis-inducing ligand. J Neurosurg, 106, 407-16. https://doi.org/10.3171/jns.2007.106.3.407
  12. Rezacova M, Vavrova J, Vokurkova D (2008). Ionizing radiation sensitizes leukemic MOLT-4 cells to TRAIL-induced apoptosis. Acta Medica, 51, 101-5.
  13. Takahashi M, Yasui H, Ogura A, et al (2008). X irradiation combined with TNF alpha-related apoptosis-inducing ligand (TRAIL) reduces hypoxic regions of human gastric adenocarcinoma xenografts in SCID mice. J Radiat Res, 49, 153-61. https://doi.org/10.1269/jrr.07082
  14. Verbrugge I, de Vries E, Tait SW, et al (2008). Ionizing radiation modulates the TRAIL death-inducing signaling complex, allowing bypass of the mitochondrial apoptosis pathway. Oncogene, 27, 574-84. https://doi.org/10.1038/sj.onc.1210696
  15. Wei F, Liu Y, Guo Y, et al (2013). MiR-99b-targeted mTOR induction contributes to irradiation resistance in pancreatic cancer. Mol Cancer, 12, 81. https://doi.org/10.1186/1476-4598-12-81
  16. Yang W, Wei J, Sun T, Liu F (2013) Effects of knockdown of miR-210 in combination with ionizing radiation on human hepatoma xenograft in nude mice. Radiat Oncol, 8, 102. https://doi.org/10.1186/1748-717X-8-102
  17. Zhang C, Kang C, Wang P, et al (2011). MicroRNA-221 and -222 regulate radiation sensitivity by targeting the PTEN pathway. Int J Radiat Oncol Biol Phys, 80, 240-8. https://doi.org/10.1016/j.ijrobp.2010.12.049
  18. Zhu W, Fu W, Hu L (2013). NVP-BEZ235, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, prominently enhances radiosensitivity of prostate cancer cell line PC-3. Cancer Biother Radiopharm, 28, 665-73. https://doi.org/10.1089/cbr.2012.1443

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