DOI QR코드

DOI QR Code

miR-421, miR-155 and miR-650: Emerging Trends of Regulation of Cancer and Apoptosis

  • Published : 2014.03.01

Abstract

It is becoming progressively more understandable that between transcription and translation there lies another versatile regulator that quantitatively controls the expression of mRNAs. Identification of miRNAs as key regulators of wide ranging signaling cascades and modulators of different cell-type and context dependent activities attracted basic and clinical scientists to study modes and mechanisms in details. In line with this approach overwhelmingly increasing in vivo and in vitro studies are deepening our understanding regarding miR-421, mir-155 and miR-650 mediated regulation of cellular activities. We also attempt to provide an overview of long non coding RNAs.

Keywords

References

  1. Alachkar H, Santhanam R, Harb JG (2013). Silvestrol exhibits significant in vivo and in vitro antileukemic activities and inhibits FLT3 and miR-155 expressions in acute myeloid leukemia. J Hematol Oncol, 6, 21. https://doi.org/10.1186/1756-8722-6-21
  2. Babar IA, Cheng CJ, Booth CJ, et al (2012). Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma. Proc Natl Acad Sci USA, 109, 1695-704. https://doi.org/10.1073/pnas.1201516109
  3. Bai Y, Qiu GR, Zhou F, et al (2013). Overexpression of DICER1 induced by the upregulation of GATA1 contributes to the proliferation and apoptosis of leukemia cells. Int J Oncol, 42,1317-24.
  4. Bertozzi D, Marinello J, Manzo SG, et al (2014). The natural inhibitor of DNA topoisomerase i, camptothecin, modulates HIF-$1\alpha$ activity by changing miR expression patterns in human cancer cells. Mol Cancer Ther, 13, 239-48.
  5. Chaulk SG, Lattanzi VJ, Hiemer SE, Fahlman RP, Varelas X (2013). The Hippo Pathway Effectors TAZ/YAP regulate dicer expression and miRNA biogenesis through Let-7. J Biol Chem, 289, 1886-91.
  6. Chen L, Tang Y, Wang J, Yan Z, Xu R (2013). miR-421 induces cell proliferation and apoptosis resistance in human nasopharyngeal carcinoma via downregulation of FOXO4. Biochem Biophys Res Commun, 435, 745-50. https://doi.org/10.1016/j.bbrc.2013.05.056
  7. Chiyomaru T, Yamamura S, Fukuhara S, et al (2013). Genistein inhibits prostate cancer cell growth by targeting miR-34a and Oncogenic HOTAIR. PLoS One, 8, 70372. https://doi.org/10.1371/journal.pone.0070372
  8. Feng L, Xie Y, Zhang H, Wu Y (2011). Down-regulation of NDRG2 gene expression in human colorectal cancer involves promoter methylation and microRNA-650. Biochem Biophys Res Commun, 406, 534-8. https://doi.org/10.1016/j.bbrc.2011.02.081
  9. Gomez-Cabello D, Adrados I, Gamarra D, et al (2013). DGCR8-mediated disruption of miRNA biogenesis induces cellular senescence in primary fibroblasts. Aging Cell, 12, 923-31. https://doi.org/10.1111/acel.12117
  10. Guo Y, Tian P, Yang C, et al (2013). Silencing the doublestranded RNA binding protein DGCR8 inhibits ovarian cancer cell proliferation, migration, and invasion. Pharm Res, [Epub ahead of print].
  11. Hao J, Zhang S, Zhou Y, et al (2011). MicroRNA 421 suppresses DPC4/Smad4 in pancreatic cancer. Biochem Biophys Res Commun, 406, 552-7. https://doi.org/10.1016/j.bbrc.2011.02.086
  12. Herbert KM, Pimienta G, Degregorio SJ, Alexandrov A, Steitz JA (2013). Phosphorylation of DGCR8 increases its intracellular stability and induces a progrowth miRNA profile. Cell Rep, 5, 1070-81. https://doi.org/10.1016/j.celrep.2013.10.017
  13. Hu H, Du L, Nagabayashi G, Seeger RC, Gatti RA (2010). ATM is down-regulated by N-Myc-regulated microRNA-421. Proc Natl Acad Sci USA, 107, 1506-11. https://doi.org/10.1073/pnas.0907763107
  14. Jiang Z, Guo J, Xiao B (2010). Increased expression of miR-421 in human gastric carcinoma and its clinical association. J Gastroenterol, 45, 17-23. https://doi.org/10.1007/s00535-009-0135-6
  15. Johansson J, Berg T, Kurzejamska E, et al (2013). MiR-155-mediated loss of C/$EBP\beta$shifts the TGF-$\beta$ response from growth inhibition to epithelial-mesenchymal transition, invasion and metastasis in breast cancer. Oncogene.
  16. Kong W, Yang H, He L, et al (2008). MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA. Mol Cell Biol, 28, 6773-84. https://doi.org/10.1128/MCB.00941-08
  17. Kopp KL, Ralfkiaer U, Gjerdrum LM, et al (2013). STAT5-mediated expression of oncogenic miR-155 in cutaneous T-cell lymphoma. Cell Cycle, 12, 1939-47. https://doi.org/10.4161/cc.24987
  18. Li P, Grgurevic S, Liu Z, et al (2013). Signal transducer and activator of transcription-3 induces MicroRNA-155 expression in chronic lymphocytic leukemia. PLoS One, 8, 64678. https://doi.org/10.1371/journal.pone.0064678
  19. Ling N, Gu J, Lei Z, et al (2013). micro RNA-155 regulates cell proliferation and invasion by targeting FOXO3a in glioma. Oncol Rep, 30, 2111-8.
  20. Liu Q, Chen J, Wang J, et al (2013). Putative tumor suppressor gene SEL1L was downregulated by aberrantly upregulated hsa-mir-155 in human pancreatic ductal adenocarcinoma. Mol Carcinog, [Epub ahead of print].
  21. Liu WJ, Zhao YP, Zhang TP, et al (2003). MLH1 as a Direct Target of MiR-155 and a Potential Predictor of Favorable Prognosis in Pancreatic Cancer. J Gastrointest Surg, 17, 1399-405.
  22. Mansour WY, Bogdanova NV, Kasten-Pisula U, et al (2013). Aberrant overexpression of miR-421 downregulates ATM and leads to a pronounced DSB repair defect and clinical hypersensitivity in SKX squamous cell carcinoma. Radiother Oncol, 106, 147-54. https://doi.org/10.1016/j.radonc.2012.10.020
  23. Mraz M, Dolezalova D, Plevova K, et al (2012). MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia. Blood, 119, 2110-3. https://doi.org/10.1182/blood-2011-11-394874
  24. Neilsen PM, Noll JE, Mattiske S, et al (2013). Mutant p53 drives invasion in breast tumors through up-regulation of miR-155. Oncogenem, 32, 2992-3000. https://doi.org/10.1038/onc.2012.305
  25. Pu J, Bai D, Yang X, et al (2012). Adrenaline promotes cell proliferation and increases chemoresistance in colon cancer HT29 cells through induction of miR-155. Biochem Biophys Res Commun, 428, 210-5. https://doi.org/10.1016/j.bbrc.2012.09.126
  26. Qin W, Ren Q, Liu T, Huang Y, Wang J. MicroRNA-155 is a novel suppressor of ovarian cancer-initiating cells that targets CLDN1. FEBS Lett, 587, 1434-9.
  27. Rozovski U, Calin GA, Setoyama T, et al (2012). Signal transducer and activator of transcription (STAT)-3 regulates microRNA gene expression in chronic lymphocytic leukemia cells. Mol Cancer, 12, 50.
  28. Sandhu SK, Volinia S, Costinean S, et al (2012). miR-155 targets histone deacetylase 4 (HDAC4) and impairs transcriptional activity of B-cell lymphoma 6 (BCL6) in the $E\mu$-miR-155 transgenic mouse model. Proc Natl Acad Sci USA, 109, 20047-52. https://doi.org/10.1073/pnas.1213764109
  29. Sun M, Xia R, Jin F, et al (2013). Downregulated long noncoding RNA MEG3 is associated with poor prognosis and promotes cell proliferation in gastric cancer. Tumour Biol, 35, 1065-73.
  30. Tang X, Wen S, Zheng D, ET AL (2013). Acetylation of drosha on the N-terminus inhibits its degradation by ubiquitination. PLoS One, 8, 72503. https://doi.org/10.1371/journal.pone.0072503
  31. Xhemalce B, Robson SC, Kouzarides T (2012). Human RNA methyltransferase BCDIN3D regulates microRNA processing. Cell, 151, 278-88. https://doi.org/10.1016/j.cell.2012.08.041
  32. Xu TP, Zhu CH, Zhang J, et al (2013). MicroRNA-155 expression has prognostic value in patients with non-small cell lung cancer and digestive system carcinomas. Asian Pac J Cancer Prev, 14, 7085-90. https://doi.org/10.7314/APJCP.2013.14.12.7085
  33. Yang L, Lin C, Jin C, et al (2013), Rosenfeld MG. lncRNAdependent mechanisms of androgen-receptor-regulated gene activation programs. Nature, 500, 598-602. https://doi.org/10.1038/nature12451
  34. Yang X, Song JH, Cheng Y, et al (2013). Long non-coding RNA HNF1A-AS1 regulates proliferation and migration in oesophageal adenocarcinoma cells. Gut.
  35. Yao Q, Sun JG, Ma H, et al (2014;). Monitoring microRNAs using a molecular beacon in CD133+/ CD338+ human lung adenocarcinoma-initiating A549 Cells. Asian Pac J Cancer Prev, 15, 161-6. https://doi.org/10.7314/APJCP.2014.15.1.161
  36. Zeng ZL, Li FJ, Gao F, Sun DS, Yao L (2013). Upregulation of miR-650 is correlated with down-regulation of ING4 and progression of hepatocellular carcinoma. J Surg Oncol, 107, 105-10. https://doi.org/10.1002/jso.23210
  37. Zhang C, Zhao J, Deng H (2013). $17\beta$-estradiol up-regulates miR-155 expression and reduces TP53INP1 expression in MCF-7 breast cancer cells. Mol Cell Biochem, 379, 201-11. https://doi.org/10.1007/s11010-013-1642-6
  38. Zhang GJ, Xiao HX, Tian HP, et al (2013). Upregulation of microRNA-155 promotes the migration and invasion of colorectal cancer cells through the regulation of claudin-1 expression. Int J Mol Med, 31, 1375-80.
  39. Zhang X, Li M, Zuo K, et al (2013). Upregulated miR-155 in papillary thyroid carcinoma promotes tumor growth by targeting APC and activating Wnt/$\beta$-Catenin signaling. J Clin Endocrinol Metab, 98, 1305-13. https://doi.org/10.1210/jc.2012-3602
  40. Zhang X, Zhu W, Zhang J, et al (2010). MicroRNA-650 targets ING4 to promote gastric cancer tumorigenicity. Biochem Biophys Res Commun, 395, 275-80. https://doi.org/10.1016/j.bbrc.2010.04.005
  41. Zhang Y, Gong W, Dai S, et al (2012). Downregulation of human farnesoid X receptor by miR-421 promotes proliferation and migration of hepatocellular carcinoma cells. Mol Cancer Res, 10, 516-22. https://doi.org/10.1158/1541-7786.MCR-11-0473
  42. Zhang Y, Wei W, Cheng N, et al (2012). Hepatitis C virusinduced up-regulation of microRNA-155 promotes hepatocarcinogenesis by activating Wnt signaling. Hepatology, 56, 1631-40. https://doi.org/10.1002/hep.25849
  43. Zhang Z, Zhu Z, Watabe K, et al (2013). Negative regulation of lncRNA GAS5 by miR-21. Cell Death Differ, 20, 1558-68. https://doi.org/10.1038/cdd.2013.110
  44. Zhao XD, Zhang W, Liang HJ, Ji WY (2013). Overexpression of miR -155 promotes proliferation and invasion of human laryngeal squamous cell carcinoma via targeting SOCS1 and STAT3. PLoS One, 8, 56395. https://doi.org/10.1371/journal.pone.0056395
  45. Zheng SR, Guo GL, Zhai Q, Zou ZY, Zhang W (2013). Effects of miR-155 antisense oligonucleotide on breast carcinoma cell line MDA-MB-157 and implanted tumors. Asian Pac J Cancer Prev, 14, 2361-6. https://doi.org/10.7314/APJCP.2013.14.4.2361
  46. Zhong XY, Yu JH, Zhang WG, et al (2012). MicroRNA-421 functions as an oncogenic miRNA in biliary tract cancer through down-regulating farnesoid X receptor expression. Gene, 493, 44-51. https://doi.org/10.1016/j.gene.2011.11.028
  47. Zhou H, Xiao B, Zhou F, (2012). MiR-421 is a functional marker of circulating tumor cells in gastric cancer patients. Biomarkers, 17, 104-10. https://doi.org/10.3109/1354750X.2011.614961

Cited by

  1. TRAIL Based Therapy: Overview of Mesenchymal Stem Cell Based Delivery and miRNA Controlled Expression of TRAIL vol.15, pp.16, 2014, https://doi.org/10.7314/APJCP.2014.15.16.6495
  2. MicroRNAs: Biogenesis, Roles for Carcinogenesis and as Potential Biomarkers for Cancer Diagnosis and Prognosis vol.15, pp.18, 2014, https://doi.org/10.7314/APJCP.2014.15.18.7489
  3. Evolution of the Mir-155 Family and Possible Targets in Cancers and the Immune System vol.15, pp.18, 2014, https://doi.org/10.7314/APJCP.2014.15.18.7547
  4. microRNA Expression Profile in Patients with Stage II Colorectal Cancer: A Turkish Referral Center Study vol.16, pp.5, 2015, https://doi.org/10.7314/APJCP.2015.16.5.1851
  5. Identification of miRNAs Potentially Involved in Bronchiolitis Obliterans Syndrome: A Computational Study vol.11, pp.8, 2016, https://doi.org/10.1371/journal.pone.0161771
  6. Ratio of microRNA-122/155 in isoniazid-induced acute liver injury in mice vol.12, pp.2, 2016, https://doi.org/10.3892/etm.2016.3375
  7. Role of Wnt/β-catenin signaling regulatory microRNAs in the pathogenesis of colorectal cancer vol.233, pp.2, 2018, https://doi.org/10.1002/jcp.25897
  8. Investigation of AID, Dicer, and Drosha Expressions in Patients with Chronic Lymphocytic Leukemia vol.46, pp.5, 2017, https://doi.org/10.1080/08820139.2017.1288241
  9. Effect of miR-155 knockdown on the reversal of doxorubicin resistance in human lung cancer A549/dox cells vol.11, pp.2, 2015, https://doi.org/10.3892/ol.2015.3995
  10. miRNA-24-3p promotes cell proliferation and regulates chemosensitivity in head and neck squamous cell carcinoma by targeting CHD5 vol.12, pp.23, 2016, https://doi.org/10.2217/fon-2016-0179