The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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A quantitative analysis of marker compounds in single herb extracts by the standard of KHP

KHP 기준에 의한 보험용 단미엑스산제의 지표성분함량 확인연구

  • Park, Sang Jun (Dept. of Herbal Medicine, College of Pharmacy, Wonkwang Univ.) ;
  • Kim, So Hyung (Dept. of Herbal Medicine, College of Pharmacy, Wonkwang Univ.) ;
  • Kim, Kyeong Seok (Dept. of Herbal Medicine, College of Pharmacy, Wonkwang Univ.) ;
  • Kim, Hyo Seon (Herbal Medicine Resources Group, Herbal Medicine Research Division, Korean Institute of Oriental Medicine) ;
  • Lee, A Yeong (Herbal Medicine Resources Group, Herbal Medicine Research Division, Korean Institute of Oriental Medicine) ;
  • Kim, Ho Kyoung (Herbal Medicine Resources Group, Herbal Medicine Research Division, Korean Institute of Oriental Medicine) ;
  • Kim, Yun-Kyung (Dept. of Herbal Medicine, College of Pharmacy, Wonkwang Univ.)
  • 박상준 (원광대학교 약학대학 한약학과) ;
  • 김소형 (원광대학교 약학대학 한약학과) ;
  • 김경석 (원광대학교 약학대학 한약학과) ;
  • 김효선 (한국한의학연구원 한약연구본부 한약자원그룹) ;
  • 이아영 (한국한의학연구원 한약연구본부 한약자원그룹) ;
  • 김호경 (한국한의학연구원 한약연구본부 한약자원그룹) ;
  • 김윤경 (원광대학교 약학대학 한약학과)
  • Received : 2014.04.25
  • Accepted : 2014.05.14
  • Published : 2014.05.30
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Abstract

Objectives : Since single extract powders was released at 1987, the insurance fee has not been changed, but the price of raw material has been increasing. According to this, Pharmaceutical company couldn't invest on quality of the product, so, the quality of single extracts went down and lost the consumer's trust. We checked the contents of marker ingredients in single extract thereby to recover the reliability of insurance-covered herbal preparations. Methods : we bought total twelve products of eight different single extracts of two main pharmaceutical companies among total 65 kinds of single extract powder stipulated in KHP (The Korean Herbal Pharmacopoeia) monograph III at Jan. 2013. Assays of selected single extract powders are performed by KHP regulation. And we surveyed price fluctuation of relevant herb raw materials from 2005 to 2012. Results : Among twelve products, eight single extract powders were suitable by the KHP regulation. But four products didn't reach the content amount of KHP. Marker contents in the single extracts product of Pueraria Root, Licorice, Peony root and Scutellaria Root of A company were 70%, 1%, 23.7% and 75.1%, respectively. Conclusions : We can acertain whether there's a quality problem in the insurance-covered single extract powders. But, A company is no longer producing these improper single extract powders. As a medicine, single extract powders needs to be strictly quality controlled by the company, and regularly monitored by the KFDA.

Keywords

References

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