The Korean Journal of Oral and Maxillofacial Pathology (대한구강악안면병리학회지)

Korean Academy of Oral and Maxillofacial Pathology (대한구강악안면병리학회)
권호 표지

Relationship between Chronic Periodontitis and Oral Cancer in Oral Squamous Cell Carcinoma Patients

구강 편평세포암 환자에서 관찰된 치주염과 구강암의 상호 연관성

  • Park, Ji Eun (Department of Oral Pathology, School of Dentistry, Pusan National University) ;
  • Park, Hae Ryoun (Department of Oral Pathology, School of Dentistry, Pusan National University) ;
  • Kim, Jin Beom (Department of Preventive Dentistry, School of Dentistry, Pusan National University) ;
  • Lee, Ji Hye (Department of Oral Pathology, School of Dentistry, Pusan National University)
  • 박지은 (부산대학교 치의학전문대학원 구강병리학교실) ;
  • 박혜련 (부산대학교 치의학전문대학원 구강병리학교실) ;
  • 김진범 (예방치과학교실) ;
  • 이지혜 (부산대학교 치의학전문대학원 구강병리학교실)
  • Received : 2014.05.07
  • Accepted : 2014.05.23
  • Published : 2014.06.30
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Abstract

Chronic inflammation has long been considered as an important contributing factor to the development of malignant tumors in various tissues. In this study, we aimed to investigate a potential association between chronic periodontitis, a representative inflammatory disease in the oral cavity, and oral squamous cell carcinoma (OSCC), the most common form of malignant tumors in the oral cavity. A retrospective study was designed to include the cases and controls, each of which consisted of patients first diagnosed with OSCC and temporomandibular disorders, respectively. The existence or a history of periodontal disease was quantitatively estimated based upon the level of alveolar bone loss (ABL) from panoramic radiographs in these groups. Unlike other covariates, including LDH, WBC count and hemoglobin, the levels of ABL measured at three independent regions (second premolar and first/second molar) were significantly higher in the OSCC group, regardless of the patients'age in most cases. Our results thus support the hypothesis that chronic periodontitis, represented by significant ABL, is an important and clinically relevant factor potentially associated with the development of OSCC.

Keywords

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