Gut and Liver

The Korean Association for the Study of the Liver (대한간학회)
권호 표지
DOI QR코드

DOI QR Code

Minimally Invasive Surgery for Gastric Cancer Treatment: Current Status and Future Perspectives

  • Son, Taeil (Department of Surgery, Eulji Medical Center, Eulji University School of Medicine) ;
  • Kwon, In Gyu (Department of Surgery, Yonsei University College of Medicine) ;
  • Hyung, Woo Jin (Department of Surgery, Yonsei University College of Medicine)
  • Received : 2014.01.28
  • Accepted : 2014.02.14
  • Published : 2014.05.15
⟨ Previous Next ⟩

Abstract

Minimally invasive surgery, which has been extensively used to treat gastric adenocarcinoma, is now regarded as one of the standard treatments for early gastric cancer, and its suitability for advanced gastric cancer is being investigated. The use of cutting-edge techniques for minimally invasive surgery enables surgeons to deliver various treatment options to minimize a patient's distress and to maintain oncologic safety. Ongoing multicenter prospective studies aim to validate the efficacy of these surgical techniques and to expand the indications of minimally invasive surgery for the treatment of gastric cancer. In this review, we summarize the current status and issues regarding minimally invasive surgery for the treatment of gastric cancer.

Keywords

References

  1. Kitano S, Shiraishi N, Fujii K, Yasuda K, Inomata M, Adachi Y. A randomized controlled trial comparing open vs laparoscopy-assisted distal gastrectomy for the treatment of early gastric cancer: an interim report. Surgery 2002;131(1 Suppl):S306-S311. https://doi.org/10.1067/msy.2002.120115
  2. Uyama I, Suda K, Satoh S. Laparoscopic surgery for advanced gastric cancer: current status and future perspectives. J Gastric Cancer 2013;13:19-25. https://doi.org/10.5230/jgc.2013.13.1.19
  3. Huscher CG, Mingoli A, Sgarzini G, et al. Totally laparoscopic total and subtotal gastrectomy with extended lymph node dissection for early and advanced gastric cancer: early and long-term results of a 100-patient series. Am J Surg 2007;194:839-844. https://doi.org/10.1016/j.amjsurg.2007.08.037
  4. Park SS, Kim CS, Mok YJ, Kim SJ, Kim HI. Gastric cancer confined to the muscularis propria: a possible candidate for laparoscopic surgery or adjuvant therapy. Scand J Gastroenterol 2005;40:450-454. https://doi.org/10.1080/00365520410009302
  5. Hur H, Jeon HM, Kim W. Laparoscopy-assisted distal gastrectomy with D2 lymphadenectomy for T2b advanced gastric cancers: three years' experience. J Surg Oncol 2008;98:515-519. https://doi.org/10.1002/jso.21155
  6. Yoshimura F, Inaba K, Kawamura Y, et al. Clinical outcome and clinicopathological characteristics of recurrence after laparoscopic gastrectomy for advanced gastric cancer. Digestion 2011;83:184-190. https://doi.org/10.1159/000322032
  7. Lee J, Kim W. Long-term outcomes after laparoscopy-assisted gastrectomy for advanced gastric cancer: analysis of consecutive 106 experiences. J Surg Oncol 2009;100:693-698. https://doi.org/10.1002/jso.21400
  8. Pak KH, Hyung WJ, Son T, et al. Long-term oncologic outcomes of 714 consecutive laparoscopic gastrectomies for gastric cancer: results from the 7-year experience of a single institute. Surg Endosc 2012;26:130-136. https://doi.org/10.1007/s00464-011-1838-3
  9. Oka S, Tanaka S, Kaneko I, et al. Endoscopic submucosal dissection for residual/local recurrence of early gastric cancer after endoscopic mucosal resection. Endoscopy 2006;38:996-1000. https://doi.org/10.1055/s-2006-944780
  10. Takenaka R, Kawahara Y, Okada H, et al. Risk factors associated with local recurrence of early gastric cancers after endoscopic submucosal dissection. Gastrointest Endosc 2008;68:887-894. https://doi.org/10.1016/j.gie.2008.03.1089
  11. Gotoda T. Endoscopic resection of early gastric cancer. Gastric Cancer 2007;10:1-11. https://doi.org/10.1007/s10120-006-0408-1
  12. Etoh T, Inomata M, Shiraishi N, Kitano S. Minimally invasive approaches for gastric cancer: Japanese experiences. J Surg Oncol 2013;107:282-288. https://doi.org/10.1002/jso.23128
  13. Volz J, Köster S, Spacek Z, Paweletz N. The influence of pneumoperitoneum used in laparoscopic surgery on an intraabdominal tumor growth. Cancer 1999;86:770-774. https://doi.org/10.1002/(SICI)1097-0142(19990901)86:5<770::AID-CNCR11>3.0.CO;2-3
  14. An JY, Heo GU, Cheong JH, Hyung WJ, Choi SH, Noh SH. Assessment of open versus laparoscopy-assisted gastrectomy in lymph node-positive early gastric cancer: a retrospective cohort analysis. J Surg Oncol 2010;102:77-81. https://doi.org/10.1002/jso.21554
  15. Son T, Hyung WJ, Lee JH, Kim YM, Noh SH. Minimally invasive surgery for serosa-positive gastric cancer (pT4a) in patients with preoperative diagnosis of cancer without serosal invasion. Surg Endosc 2014;28:866-874. https://doi.org/10.1007/s00464-013-3236-5
  16. Lee SW, Nomura E, Bouras G, Tokuhara T, Tsunemi S, Tanigawa N. Long-term oncologic outcomes from laparoscopic gastrectomy for gastric cancer: a single-center experience of 601 consecutive resections. J Am Coll Surg 2010;211:33-40. https://doi.org/10.1016/j.jamcollsurg.2010.03.018
  17. Huscher CG, Mingoli A, Sgarzini G, et al. Laparoscopic versus open subtotal gastrectomy for distal gastric cancer: five-year results of a randomized prospective trial. Ann Surg 2005;241:232-237. https://doi.org/10.1097/01.sla.0000151892.35922.f2
  18. Strong VE, Devaud N, Allen PJ, Gonen M, Brennan MF, Coit D. Laparoscopic versus open subtotal gastrectomy for adenocarcinoma: a case-control study. Ann Surg Oncol 2009;16:1507-1513. https://doi.org/10.1245/s10434-009-0386-8
  19. Oh SY, Kwon S, Lee KG, et al. Outcomes of minimally invasive surgery for early gastric cancer are comparable with those for open surgery: analysis of 1,013 minimally invasive surgeries at a single institution. Surg Endosc 2014;28:789-795. https://doi.org/10.1007/s00464-013-3256-1
  20. Lee JH, Han HS, Lee JH. A prospective randomized study comparing open vs laparoscopy-assisted distal gastrectomy in early gastric cancer: early results. Surg Endosc 2005;19:168-173. https://doi.org/10.1007/s00464-004-8808-y
  21. Hayashi H, Ochiai T, Shimada H, Gunji Y. Prospective randomized study of open versus laparoscopy-assisted distal gastrectomy with extraperigastric lymph node dissection for early gastric cancer. Surg Endosc 2005;19:1172-1176. https://doi.org/10.1007/s00464-004-8207-4
  22. Kim YW, Baik YH, Yun YH, et al. Improved quality of life outcomes after laparoscopy-assisted distal gastrectomy for early gastric cancer: results of a prospective randomized clinical trial. Ann Surg 2008;248:721-727. https://doi.org/10.1097/SLA.0b013e318185e62e
  23. Kim HH, Hyung WJ, Cho GS, et al. Morbidity and mortality of laparoscopic gastrectomy versus open gastrectomy for gastric cancer: an interim report: a phase III multicenter, prospective, randomized Trial (KLASS Trial). Ann Surg 2010;251:417-420. https://doi.org/10.1097/SLA.0b013e3181cc8f6b
  24. Ohtani H, Tamamori Y, Noguchi K, et al. Meta-analysis of laparoscopy-assisted and open distal gastrectomy for gastric cancer. J Surg Res 2011;171:479-485. https://doi.org/10.1016/j.jss.2010.04.008
  25. Vinuela EF, Gonen M, Brennan MF, Coit DG, Strong VE. Laparoscopic versus open distal gastrectomy for gastric cancer: a meta-analysis of randomized controlled trials and high-quality nonrandomized studies. Ann Surg 2012;255:446-456. https://doi.org/10.1097/SLA.0b013e31824682f4
  26. Park do J, Lee JH, Ahn SH, Eng AK, Kim HH. Single-port laparoscopic distal gastrectomy with D1+beta lymph node dissection for gastric cancers: report of 2 cases. Surg Laparosc Endosc Percutan Tech 2012;22:e214-e216. https://doi.org/10.1097/SLE.0b013e318253df9b
  27. Kunisaki C, Ono HA, Oshima T, Makino H, Akiyama H, Endo I. Relevance of reduced-port laparoscopic distal gastrectomy for gastric cancer: a pilot study. Dig Surg 2012;29:261-268. https://doi.org/10.1159/000341677
  28. Song KY, Park CH, Kang HC, et al. Is totally laparoscopic gastrectomy less invasive than laparoscopy-assisted gastrectomy? Prospective, multicenter study. J Gastrointest Surg 2008;12:1015-1021. https://doi.org/10.1007/s11605-008-0484-0
  29. Kim JJ, Song KY, Chin HM, et al. Totally laparoscopic gastrectomy with various types of intracorporeal anastomosis using laparoscopic linear staplers: preliminary experience. Surg Endosc 2008;22:436-442. https://doi.org/10.1007/s00464-007-9446-y
  30. Kanaya S, Gomi T, Momoi H, et al. Delta-shaped anastomosis in totally laparoscopic Billroth I gastrectomy: new technique of intraabdominal gastroduodenostomy. J Am Coll Surg 2002;195:284-287. https://doi.org/10.1016/S1072-7515(02)01239-5
  31. Okabe H, Obama K, Tanaka E, et al. Intracorporeal esophagojejunal anastomosis after laparoscopic total gastrectomy for patients with gastric cancer. Surg Endosc 2009;23:2167-2171. https://doi.org/10.1007/s00464-008-9987-8
  32. Kim MG, Kim KC, Kim BS, et al. A totally laparoscopic distal gastrectomy can be an effective way of performing laparoscopic gastrectomy in obese patients (body mass index≥30). World J Surg 2011;35:1327-1332. https://doi.org/10.1007/s00268-011-1034-6
  33. Memon MA, Khan S, Yunus RM, Barr R, Memon B. Meta-analysis of laparoscopic and open distal gastrectomy for gastric carcinoma. Surg Endosc 2008;22:1781-1789. https://doi.org/10.1007/s00464-008-9925-9
  34. Chen XZ, Hu JK, Yang K, Wang L, Lu QC. Short-term evaluation of laparoscopy-assisted distal gastrectomy for predictive early gastric cancer: a meta-analysis of randomized controlled trials. Surg Laparosc Endosc Percutan Tech 2009;19:277-284. https://doi.org/10.1097/SLE.0b013e3181b080d3
  35. Kodera Y, Fujiwara M, Ohashi N, et al. Laparoscopic surgery for gastric cancer: a collective review with meta-analysis of randomized trials. J Am Coll Surg 2010;211:677-686. https://doi.org/10.1016/j.jamcollsurg.2010.07.013
  36. Zorcolo L, Rosman AS, Pisano M, et al. A meta-analysis of prospective randomized trials comparing minimally invasive and open distal gastrectomy for cancer. J Surg Oncol 2011;104:544-551. https://doi.org/10.1002/jso.21980
  37. Zhao Y, Yu P, Hao Y, et al. Comparison of outcomes for laparoscopically assisted and open radical distal gastrectomy with lymphadenectomy for advanced gastric cancer. Surg Endosc 2011;25:2960-2966. https://doi.org/10.1007/s00464-011-1652-y
  38. Gordon AC, Kojima K, Inokuchi M, Kato K, Sugihara K. Long-term comparison of laparoscopy-assisted distal gastrectomy and open distal gastrectomy in advanced gastric cancer. Surg Endosc 2013;27:462-470. https://doi.org/10.1007/s00464-012-2459-1
  39. Pugliese R, Maggioni D, Sansonna F, et al. Subtotal gastrectomy with D2 dissection by minimally invasive surgery for distal adenocarcinoma of the stomach: results and 5-year survival. Surg Endosc 2010;24:2594-2602. https://doi.org/10.1007/s00464-010-1014-1
  40. Pugliese R, Maggioni D, Sansonna F, et al. Outcomes and survival after laparoscopic gastrectomy for adenocarcinoma: analysis on 65 patients operated on by conventional or robot-assisted minimal access procedures. Eur J Surg Oncol 2009;35:281-288. https://doi.org/10.1016/j.ejso.2008.02.001
  41. Wei HB, Wei B, Qi CL, et al. Laparoscopic versus open gastrectomy with D2 lymph node dissection for gastric cancer: a meta-analysis. Surg Laparosc Endosc Percutan Tech 2011;21:383-390. https://doi.org/10.1097/SLE.0b013e31822d02dc
  42. Miyashiro I. What is the problem in clinical application of sentinel node concept to gastric cancer surgery? J Gastric Cancer 2012;12:7-12. https://doi.org/10.5230/jgc.2012.12.1.7
  43. Lee JH, Ryu KW, Kim CG, et al. Sentinel node biopsy using dye and isotope double tracers in early gastric cancer. Ann Surg Oncol 2006;13:1168-1174. https://doi.org/10.1245/s10434-006-9038-4
  44. Kim MC, Kim HH, Jung GJ, et al. Lymphatic mapping and sentinel node biopsy using 99mTc tin colloid in gastric cancer. Ann Surg 2004;239:383-387. https://doi.org/10.1097/01.sla.0000114227.70480.14
  45. Park do J, Kim HH, Park YS, et al. Simultaneous indocyanine green and (99m)Tc-antimony sulfur colloid-guided laparoscopic sentinel basin dissection for gastric cancer. Ann Surg Oncol 2011;18:160-165. https://doi.org/10.1245/s10434-010-1221-y
  46. Kitagawa Y, Takeuchi H, Takagi Y, et al. Sentinel node mapping for gastric cancer: a prospective multicenter trial in Japan. J Clin Oncol 2013;31:3704-3710. https://doi.org/10.1200/JCO.2013.50.3789
  47. Park JY, Ryu KW, Eom BW, et al. Proposal of the surgical options for primary tumor control during sentinel node navigation surgery based on the discrepancy between preoperative and postoperative early gastric cancer diagnoses. Ann Surg Oncol 2014;21:1123-1129. https://doi.org/10.1245/s10434-013-3427-2
  48. Lee JH, Lee MS, Kim HH, et al. Feasibility of laparoscopic partial gastrectomy with sentinel node basin dissection in a porcine model. Surg Endosc 2011;25:1070-1075. https://doi.org/10.1007/s00464-010-1318-1
  49. Maki T, Shiratori T, Hatafuku T, Sugawara K. Pylorus-preserving gastrectomy as an improved operation for gastric ulcer. Surgery 1967;61:838-845.
  50. Suh YS, Han DS, Kong SH, et al. Laparoscopy-assisted pylorus-preserving gastrectomy is better than laparoscopy-assisted distal gastrectomy for middle-third early gastric cancer. Ann Surg 2014;259:485-493. https://doi.org/10.1097/SLA.0b013e318294d142
  51. Kim BH, Hong SW, Kim JW, Choi SH, Yoon SO. Oncologic safety of pylorus-preserving gastrectomy in the aspect of micrometastasis in lymph nodes at stations 5 and 6. Ann Surg Oncol 2014;21:533-538. https://doi.org/10.1245/s10434-013-3252-7
  52. Tanimura S, Higashino M, Fukunaga Y, et al. Laparoscopic gastrectomy with regional lymph node dissection for upper gastric cancer. Br J Surg 2007;94:204-207. https://doi.org/10.1002/bjs.5542
  53. Matsui H, Okamoto Y, Nabeshima K, Kondoh Y, Ogoshi K, Makuuchi H. Endoscopy-assisted gastric resection: a safe and reliable procedure for tumor clearance during laparoscopic high distal or proximal gastrectomy. Surg Endosc 2009;23:1146-1149. https://doi.org/10.1007/s00464-009-0354-1
  54. Sano T, Hollowood A. Early gastric cancer: diagnosis and less invasive treatments. Scand J Surg 2006;95:249-255. https://doi.org/10.1177/145749690609500407
  55. Nunobe S, Sasako M, Saka M, Fukagawa T, Katai H, Sano T. Symptom evaluation of long-term postoperative outcomes after pylorus-preserving gastrectomy for early gastric cancer. Gastric Cancer 2007;10:167-172. https://doi.org/10.1007/s10120-007-0434-7
  56. Shinohara H, Sonoda T, Niki M, Nomura E, Nishiguchi K, Tanigawa N. Laparoscopically-assisted pylorus-preserving gastrectomy with preservation of the vagus nerve. Eur J Surg 2002;168:55-58. https://doi.org/10.1080/110241502317307580
  57. Hiki N, Kaminishi M. Pylorus-preserving gastrectomy in gastric cancer surgery: open and laparoscopic approaches. Langenbecks Arch Surg 2005;390:442-447. https://doi.org/10.1007/s00423-005-0573-4
  58. Takeuchi H, Kitagawa Y. Is pylorus-preserving gastrectomy universally applicable to early gastric cancer of the mid stomach? Ann Surg Oncol 2014;21:356-357.
  59. Morita S, Katai H, Saka M, Fukagawa T, Sano T, Sasako M. Outcome of pylorus-preserving gastrectomy for early gastric cancer. Br J Surg 2008;95:1131-1135. https://doi.org/10.1002/bjs.6295
  60. Ogoshi K, Okamoto Y, Nabeshima K, et al. Focus on the conditions of resection and reconstruction in gastric cancer: what extent of resection and what kind of reconstruction provide the best outcomes for gastric cancer patients? Digestion 2005;71:213-224. https://doi.org/10.1159/000087046
  61. Masuzawa T, Takiguchi S, Hirao M, et al. Comparison of perioperative and long-term outcomes of total and proximal gastrectomy for early gastric cancer: a multi-institutional retrospective study. World J Surg 2014;38:1100-1106. https://doi.org/10.1007/s00268-013-2370-5
  62. Ahn SH, Jung DH, Son SY, Lee CM, Park DJ, Kim HH. Laparoscopic double-tract proximal gastrectomy for proximal early gastric cancer. Gastric Cancer. Epub 2013 Sep 20. http://dx.doi.org/10.1007/s10120-013-0303-5.
  63. Kinoshita T, Gotohda N, Kato Y, Takahashi S, Konishi M, Kinoshita T. Laparoscopic proximal gastrectomy with jejunal interposition for gastric cancer in the proximal third of the stomach: a retrospective comparison with open surgery. Surg Endosc 2013;27:146-153. https://doi.org/10.1007/s00464-012-2401-6
  64. Shinohara T, Uyama I, Kanaya S, et al. Totally laparoscopic pancreaticoduodenectomy for locally advanced gastric cancer. Langenbecks Arch Surg 2009;394:733-737. https://doi.org/10.1007/s00423-009-0492-x
  65. Song J, Kim JY, Kim S, et al. Laparoscopic completion total gastrectomy in remnant gastric cancer: technical detail and experience of two cases. Hepatogastroenterology 2009;56:1249-1252.
  66. Hyung WJ, Lim JS, Song J, Choi SH, Noh SH. Laparoscopic spleen-preserving splenic hilar lymph node dissection during total gastrectomy for gastric cancer. J Am Coll Surg 2008;207:e6-e11.
  67. Uyama I, Sugioka A, Matsui H, Fujita J, Komori Y, Hasumi A. Laparoscopic pancreas-preserving total gastrectomy for proximal gastric cancer: a case and technical report. Surg Endosc 2001;15:217-218. https://doi.org/10.1007/BF03036283
  68. Shinohara T, Kanaya S, Taniguchi K, Fujita T, Yanaga K, Uyama I. Laparoscopic total gastrectomy with D2 lymph node dissection for gastric cancer. Arch Surg 2009;144:1138-1142. https://doi.org/10.1001/archsurg.2009.223
  69. Maeso S, Reza M, Mayol JA, et al. Efficacy of the Da Vinci surgical system in abdominal surgery compared with that of laparoscopy: a systematic review and meta-analysis. Ann Surg 2010;252:254-262. https://doi.org/10.1097/SLA.0b013e3181e6239e
  70. Marano A, Choi YY, Hyung WJ, Kim YM, Kim J, Noh SH. Robotic versus laparoscopic versus open gastrectomy: a meta-analysis. J Gastric Cancer 2013;13:136-148. https://doi.org/10.5230/jgc.2013.13.3.136
  71. Song J, Oh SJ, Kang WH, Hyung WJ, Choi SH, Noh SH. Robot-assisted gastrectomy with lymph node dissection for gastric cancer: lessons learned from an initial 100 consecutive procedures. Ann Surg 2009;249:927-932. https://doi.org/10.1097/01.sla.0000351688.64999.73
  72. Gutt CN, Oniu T, Mehrabi A, Kashfi A, Schemmer P, Büchler MW. Robot-assisted abdominal surgery. Br J Surg 2004;91:1390-1397. https://doi.org/10.1002/bjs.4700
  73. Baek SJ, Lee DW, Park SS, Kim SH. Current status of robot-assisted gastric surgery. World J Gastrointest Oncol 2011;3:137-143. https://doi.org/10.4251/wjgo.v3.i10.137
  74. Wall J, Marescaux J. Robotic gastrectomy is safe and feasible, but real benefits remain elusive. Arch Surg 2011;146:1092. https://doi.org/10.1001/archsurg.2011.198
  75. Kim MC, Heo GU, Jung GJ. Robotic gastrectomy for gastric cancer: surgical techniques and clinical merits. Surg Endosc 2010;24:610-615. https://doi.org/10.1007/s00464-009-0618-9
  76. Yoon HM, Kim YW, Lee JH, et al. Robot-assisted total gastrectomy is comparable with laparoscopically assisted total gastrectomy for early gastric cancer. Surg Endosc 2012;26:1377-1381. https://doi.org/10.1007/s00464-011-2043-0
  77. Woo Y, Hyung WJ, Pak KH, et al. Robotic gastrectomy as an oncologically sound alternative to laparoscopic resections for the treatment of early-stage gastric cancers. Arch Surg 2011;146:1086-1092. https://doi.org/10.1001/archsurg.2011.114
  78. Xiong B, Ma L, Zhang C. Robotic versus laparoscopic gastrectomy for gastric cancer: a meta-analysis of short outcomes. Surg Oncol 2012;21:274-280. https://doi.org/10.1016/j.suronc.2012.05.004
  79. Coratti A, Annecchiarico M, Di Marino M, Gentile E, Coratti F, Giulianotti PC. Robot-assisted gastrectomy for gastric cancer: current status and technical considerations. World J Surg 2013;37:2771-2781. https://doi.org/10.1007/s00268-013-2100-z
  80. Park do J, Han SU, Hyung WJ, et al. Long-term outcomes after laparoscopy-assisted gastrectomy for advanced gastric cancer: a large-scale multicenter retrospective study. Surg Endosc 2012;26:1548-1553. https://doi.org/10.1007/s00464-011-2065-7
  81. Yang HK, Suh YS, Lee HJ. Minimally invasive approaches for gastric cancer-Korean experience. J Surg Oncol 2013;107:277-281. https://doi.org/10.1002/jso.23179
  82. Kim YW, Yoon HM, Eom BW, Park JY. History of minimally invasive surgery for gastric cancer in Korea. J Gastric Cancer 2012;12:13-17. https://doi.org/10.5230/jgc.2012.12.1.13

Cited by

  1. Mitogen-Activated Protein Kinase Signal Transduction in Solid Tumors vol.15, pp.20, 2014, https://doi.org/10.7314/apjcp.2014.15.20.8539
  2. Primary gastric tumors in infants and children: 15 cases of 20-year report vol.142, pp.5, 2014, https://doi.org/10.1007/s00432-015-2103-2
  3. Von HIPEC über Robotik bis zu Fast Track vol.158, pp.13, 2016, https://doi.org/10.1007/s15006-016-8514-4
  4. Recent developments and innovations in gastric cancer vol.22, pp.17, 2016, https://doi.org/10.3748/wjg.v22.i17.4307
  5. Laparoscopic and robot-assisted gastrectomy for gastric cancer: Current considerations vol.22, pp.25, 2014, https://doi.org/10.3748/wjg.v22.i25.5694
  6. Feasibility study on expanded indication for endoscopic submucosal dissection of intramucosal poorly differentiated early gastric cancer vol.22, pp.29, 2016, https://doi.org/10.3748/wjg.v22.i29.6736
  7. Sentinel Lymph Node Mapping In Gastric Cancer Surgery: Current Status vol.62, pp.4, 2014, https://doi.org/10.1515/amma-2016-0047
  8. Advances in Laparoscopic and Robotic Gastrectomy for Gastric Cancer vol.23, pp.1, 2014, https://doi.org/10.1007/s12253-016-0131-0
  9. Robotic Surgery: A Solution in Search of a Problem-A Bayesian Analysis of 343 Robotic Procedures Performed by a Single Surgical Team vol.27, pp.4, 2017, https://doi.org/10.1089/lap.2016.0323
  10. Comparison Between Minimally Invasive and Open Gastrectomy for Gastric Cancer in Europe: A Systematic Review and Meta-analysis vol.106, pp.1, 2014, https://doi.org/10.1177/1457496916630654
  11. Study of miR-143 expression in stomach cancer vol.16, pp.4, 2014, https://doi.org/10.3892/ol.2018.9173
  12. Rethinking the next step after unexpected results associated with minimally invasive radical hysterectomy for early cervical cancer vol.30, pp.2, 2014, https://doi.org/10.3802/jgo.2019.30.e43
  13. Laparoscopic D2 Gastrectomy for Gastric Cancer: Mid-Term Results and Current Evidence vol.29, pp.4, 2014, https://doi.org/10.1089/lap.2018.0474
  14. Clinical Implementation of Precision Medicine in Gastric Cancer vol.19, pp.3, 2014, https://doi.org/10.5230/jgc.2019.19.e25
  15. MiR-489 inhibited the development of gastric cancer via regulating HDAC7 and PI3K/AKT pathway vol.18, pp.None, 2014, https://doi.org/10.1186/s12957-020-01846-3
  16. Long-term Comparison of Robotic and Laparoscopic Gastrectomy for Gastric Cancer : A Propensity Score-weighted Analysis of 2084 Consecutive Patients vol.274, pp.1, 2021, https://doi.org/10.1097/sla.0000000000003845
  17. Transforming Growth Factor Beta 1 Affects Gastric Cancer Cell Proliferation, Migration, and Invasion by Regulating Phosphatase and Tensin Homolog vol.11, pp.4, 2021, https://doi.org/10.1166/jbt.2021.2578