Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Elevated Serum Ferritin Levels in Patients with Hematologic Malignancies

  • Zhang, Xue-Zhong (Department of Hematology, Nanjing First Hospital, Nanjing Medical University) ;
  • Su, Ai-Ling (Department of Hematology, Nanjing First Hospital, Nanjing Medical University) ;
  • Hu, Ming-Qiu (Department of Hematology, Nanjing First Hospital, Nanjing Medical University) ;
  • Zhang, Xiu-Qun (Department of Hematology, Nanjing First Hospital, Nanjing Medical University) ;
  • Xu, Yan-Li (Department of Hematology, Nanjing First Hospital, Nanjing Medical University)
  • Published : 2014.08.15
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Abstract

Purpose: To retrospectively analyze variability and clinical significance of serum ferritin levels in Chinese patients with hematologic malignancies. Materials and Methods: Serum ferritin were measured by radioimmunoassay, using a kit produced by the Beijing Institute of Atomic Energy. Patients with hematologic malignancies, and treated in the Department of Hematology in Nanjing First Hospital and fulfilled study criteria were recruited. Results: Of 473 patients with hematologic malignancies, 262 patients were diagnosed with acute leukemia, 131 with lymphoma and 80 with multiple myeloma. Serum ferritin levels of newly diagnosed and recurrent patients were significantly higher than those entering complete remission stage or in the control group (p<0.001). Conclusions: Serum ferritin lever in patients with hematologic malignancies at early stage and recurrent stage are significantly increased, so that detection and surveillance of changes of serum ferritin could be helpful in assessing conditions and prognosis of this patient cohort.

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