Oral Biology Research (구강생물연구)

The Institute of Dental Science, Chosun University (조선대학교 치의학연구원)
권호 표지

Bisphosphonate-related osteonecrosis of the jaws: A literature review

비스포스포네이트 관련 악골 골괴사: 문헌고찰

  • Oh, Ji-Su (Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University) ;
  • Kim, Su-Gwan (Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University) ;
  • You, Jae-Seek (Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University) ;
  • Kim, Ji-Won (Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University) ;
  • Kim, Eun-Sik (Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University) ;
  • Lim, Kyung-Seop (Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University) ;
  • Kim, Cheol-Man (Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University)
  • 오지수 (조선대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 김수관 (조선대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 유재식 (조선대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 김지원 (조선대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 김은식 (조선대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 임경섭 (조선대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 김철만 (조선대학교 치의학전문대학원 구강악안면외과학교실)
  • Received : 2014.02.06
  • Accepted : 2014.02.18
  • Published : 2014.02.28
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Abstract

The aim of the present study was to review bisphosphonate osteonecrosis of the jaws (BRONJ). Bisphosphonate, pathophysiology, risk factors, staging, clinical manifestation, treatments, and prevention of BRONJ were investigated through a literature search. Bisphosphonates are a group of drugs that treat diseases related to bone resorption such as Paget's disease, osteoporosis, and osseous metastases. BRONJ is defined as exposure and necrosis of bone in the oral cavity for at least 8 weeks in patients receiving bisphosphonate and with no history of radiotherapy of the jaws. Many articles have reported risk factors associated with BRONJ such as systemic diseases, oral infection, poor oral hygiene, and intraoral trauma. The objectives of BRONJ treatment are to minimize necrosis and relieve symptoms. Many treatments are suggested from conservative treatment to radical intervention, but this remains controversial. BRONJ remains a difficult condition to treat although many studies are being carried out.

Keywords

Acknowledgement

Supported by : Chosun University

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