Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Ribes fasciculatum var. chinense Attenuated Allergic Inflammation In Vivo and In Vitro

  • Jung, Ji-Wook (Department of Herbal Medicinal Pharmacology, College of Health and Welfare, Daegu Haany University) ;
  • Kim, Su-Jin (Department of Herbal Medicinal Pharmacology, College of Health and Welfare, Daegu Haany University) ;
  • Ahn, Eun-Mi (Department of Herbal Foodceutical Science, Daegu Haany University) ;
  • Oh, Sa-Rang (Department of Natural Pharmacy, College of Pharmacy, Keimyung University) ;
  • Lee, Hye-Ja (Department of Herb Science, Shinsung University) ;
  • Jeong, Ji-Ahn (Department of Herb Science, Shinsung University) ;
  • Lee, Ju-Young (Department of Herb Science, Shinsung University)
  • Received : 2014.02.04
  • Accepted : 2014.09.02
  • Published : 2014.11.30
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Abstract

Ribes fasciculatum var. chinense MAX. (R. fasciculatum) has traditionally been used in Korea to treat inflammatory diseases. However, the exact mechanism that accounts for the anti-inflammatory effect of R. fasciculatum is not completely understood. We aimed to ascertain the pharmacological effects of R. fasciculatum on both compound 48/80- or histamine-induced scratching behaviors and 2, 4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) in mice. Additionally, to find a possible explanation for the anti-inflammatory effects of R. fasciculatum, we evaluated the effects of R. fasciculatum on the production of inflammatory mediators in LPS-stimulated macrophage cells. Treatment of R. fasciculatum significantly reduced compound 48/80- or histamine-induced the pruritus in mice. R. fasciculatum attenuated the AD symptoms such as eczematous, erythema and dryness and serum IgE levels in AD model. Additionally, R. fasciculatum inhibited the production of tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) and interleukin-6 (IL-6). The maximal rates of TNF-${\alpha}$ and IL-6 inhibition by R. fasciculatum (1 mg/ml) were approximately 32.12% and 46.24%, respectively. We also showed that R. fasciculatum inhibited the activation of nuclear factor-kappa B in LPS-stimulated macrophages. Collectively, the findings of this study provide us with novel insights into the pharmacological actions of R. fasciculatum as a potential molecule for use in the treatment of allergic inflammatory diseases.

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References

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